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Dabigatran is an oral, reversible thrombin inhibitor that has shown promising results in large clinical trials. Laboratory monitoring is not needed but the effects on common coagulation assays are incompletely known. Dabigatran was added to plasma from healthy subjects in the concentration range 0-1,000 μg/l and analysed using several reagents for activated thromboplastin time (APTT), prothrombin
IntroductionThe child’s best interest has moral foundations in medicine and has existed for decades in the field of paediatrics. Indeed, there are recommendations for the child’s best interests to be a primary consideration in all matters that concern the child. However, there is uncertainty in the literature over how the child’s best interests may be safeguarded within healthcare. AimThe aim of t
Accurate detection of cancer-associated molecular abnormalities in tumors could make cancer treatment more personalized. Affibody molecules enable high contrast imaging of tumor-associated protein expression shortly after injection. The use of the generator-produced positron-emitting radionuclide (68)Ga should increase sensitivity of HER2 imaging. The chemical nature of radionuclides and chelators
Objectives. The subcellular localization of the breast cancer susceptibility gene product BRCA1 has been controversial. Discrepant results have been reported during the past 3 years, partially because of the unavailability of highly specific reagents for BRCA1 protein. Our objective was to characterize the BRCA1-like immunoreactivity that is detected in human seminal plasma by using monoclonal and
The aim of this thesis was to conduct a prospective investigation of anxiety and its long-term effects on women referred for colposcopy after an abnormal cervical smear. The thesis comprises four articles, all based on a study of the current life situation, anxiety (Spielberger's state-trait anxiety inventory, STAI), depression (Montogomery Isberg Depression Rating Scale self-rate), psychosexualit
Even in the tyrosine kinase inhibitor era, allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as standard care for adult Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL). In this retrospective national study, we have reviewed the outcome after HSCT in Sweden for adult Ph-positive ALL between 2000 and 2009. In total, 51 patients with median age 42 (range 20-66) years
Objectives: To describe dietary glycaemic index (GI) and glycaemic load (GL) values in the population participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study according to food groups, nutrients and lifestyle characteristics. Methods: Single 24-h dietary recalls (24-HDRs) from 33 566 subjects were used to calculate dietary GI and GL, and an ad hoc database was
The administration of hydroxocobalamin (OHCob), alone or with sodium thiosulfate, is a standard therapy for cyanide poisoning. OHCob is a red chromophore, and its interference with co-oximetric and colorimetric laboratory measurements has been evaluated in a few conflicting reports. The interference of OHCob was investigated in samples spiked with 10 different concentrations of OHCob (0-1500 mg/L)
Objective. Collagenous colitis (CC) and lymphocytic colitis (LC) are two subtypes of microscopic colitis (MC). Even though they most often are described as different entities they share many clinical and histological features. The aim of this study was to investigate the occurrence of conversion between CC and LC in a larger cohort of patients. Materials and methods. All 664 patients in our Pathol
Genetic alterations underlying the development of the cancer of the nose and paranasal sinuses (sinonasal cancer, SNC), a rare cancer that can be included in the group of head and neck cancers, are still largely unknown. We recently reported that TP53 mutations are a common feature of SNC, with an overall frequency of 77%, and they show association to adenocarcinoma and wood-dust exposure [15]. In
Background: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC). Objective: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate whether coffee intakes, tea intakes, or both are associated with the risk of EOC
In this work, the syntheses, structure, superoxide dismutase (SOD) activity, and the catalytic use in the oxidative transformations of cyclohexene of covalently grafted Fe(III)-complexes formed with various or various combinations of C-protected amino acid (l-histidine, l-tyrosine, l-cysteine and l-cystine) ligands are presented. The structural features of the surface complexes were studied by XAN
Cue-conflict experiments were performed to study the compass calibration of one predominantly diurnal migrant, the dunnock (Prunella modularis), and two species of nocturnal passerine migrants, the sedge warbler (Acrocephalus schoenobaenus), and the European robin (Erithacus rubecula) during autumn migration in South Sweden. The birds' orientation was recorded in circular cages under natural clear
The overall aim of this work was to increase our knowledge of newborn infants and their mothers, gain a better understanding of attachment and the infants' development and identify infants at risk for poorer emotional, social and cognitive development. An interdisciplinary approach was used. Six studies are included in the thesis. Non-nutritive sucking (NNS) and its relation to neurobehavioural st
Popular Abstract in SwedishDetta är en avhandling om relationen mellan patient och personal i svensk allmänpsykiatrisk vård. Arbetet började med att författaren under andra hälften av 1990-talet blev ombedd av dåvarande Malmöhu's Län's Landsting's Etiska Kommitté att göra en utredning om vad patienterna inom psykiatrin uppfattade som god psykiatrisk vård. Utredningen (som sedermera resulterade i aThe main aim of the thesis was to study different aspects of the therapeutic relationship in general psychiatric care, within various routine psychiatric settings with a variety of diagnostic patient groups and different staff groups. The first study investigated the patients' opinion on what constituted good psychiatric care. One outpatient and one inpatient sample were interviewed. The main resu
interactIVe introduces safety systems that autonomously brake and steer. The driver is continuously supported by interactIVe assistance systems. They warn the driver in potentially dangerous situations. The systems do not only react to driving situations, but are also able to actively intervene in order to protect occupants and vulnerable road users. The objective of interactIVe is to develop new
Popular Abstract in Swedish Vår galax, Vintergatan, är en spiralgalax som innehåller bortåt 200 miljarder stjärnor. En mörk natt kan man urskilja ca 3000 av dessa på himlavalvet. Tittar man noggrant så kan man också se ett diffust ljusband som sträcker sig genom, bland andra, stjärnbilderna Skytten och Cassiopeia. Detta diffusa band är det samlade ljuset från alla de miljarder stjärnor i VintergatThe origin and evolution of the thin and thick disks in the Galaxy have been studied by means of detailed stellar abundances. High-resolution spectra of 102 F and G dwarf stars have been obtained with the spectrographs on the ESO 3.6-m and ESO 1.5-m telescopes on La Silla (Chile), the Very Large Telescope (VLT) on Paranal (Chile), and the Nordic Optical Telescope (NOT) on La Palma (Canary Islands,
Massive destruction of flint and stone artefacts by fire has been found at two sites in south-eastern Scania, the southernmost county of Sweden. At the site of Svartskylle, dated to the Early Funnel-Necked Beaker Culture (TRB) at about 3400 cal. BC, fragments showed that several thin-butted flint axeheads as well as a small number of thin-bladed axeheads had been heavily fragmented by fire. During
Knowledge of the forest biomass and its change in time is crucial to understanding the carbon cycle and its interactions with climate change. LiDAR (Light Detection and Ranging) technology, in this respect, has proven to be a valuable tool, providing reliable estimates of aboveground biomass (AGB). The overall goal of this study was to develop a method for assessing AGB using a synergy of low poin
