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Popular science summary: Predictive model for unbound brain-to-plasma concentration ratio Blood-brain barrier (BBB) is a dynamic interface evolved to protect the brain from exposure to toxic xenobiotics and to maintain homeostasis. Distribution of drugs across BBB is critical for any drug discovery project. A drug designed for a target in brain has to pass through the BBB in sufficient concentr
In this study the hypothesis that particular groups of organisms showing common physiological characteristics play an important role for the calculation of Trophic Magnification Factors (TMFs) of anthropogenic pollutants is tested. For this purpose data were collected from previous studies of biomagnification and analysed. Monte Carlo simulations of the linear regression TMF model were run for mer
The intention with this study has been to research social workers experience in handling honor-related cases. I interviewed four social workers through semi-structured interviewing. The interviewed was both government practicing social workers and social workers who mainly practices different kinds of conversation support. Many topics were found to repeatedly appear through the interviews that wer
The aim of this study has been to investigate how Schofield and Beek’s five caregiving dimensions can create an understanding about the importance of the attachment for a foster placement. The reason these five dimensions were developed was to research the parenthood of foster carers based on the attachment theory. Therefore these became suitable as analytic tools for this study. The methodologica
This study assesses the performance of buildings affected by climate change under future climate predictions for three time-periods until the end of the 21st century. Objects studied are residential multi-storey buildings, originally built before 1970 and retrofitted during the last decade. A total of four actual retrofit projects, as they were performed, in Denmark and Germany were assessed in th
The overall aim of this thesis was to describe parents’ expectations, experiences and reactions to a routine ultrasound examination during the second trimester of pregnancy and to develop, test and use a questionnaire. The aim was also to conceptualize the parents’ experiences and ways of handling the situation when the diagnosis was a non-viable fetus. The data for this thesis was collected betw
The objectives of the present study were to estimate long-term risks of osteoporotic fractures. The incidence of hip, distal forearm, proximal humerus and vertebral fracture were obtained from patient records in Malmo, Sweden. Vertebral fractures were confined to those coming to clinical attention, either as an inpatient or an outpatient case. Patient records were examined to exclude individuals w
Objectives: To develop European League Against Rheumatism (EULAR) recommendations for the management of small and medium vessel vasculitis. Methods: An expert group ( consisting of 10 rheumatologists, 3 nephrologists, 2 immunologists, 2 internists representing 8 European countries and the USA, a clinical epidemiologist and a representative from a drug regulatory agency) identified 10 topics for a
Background: There is insufficient information regarding the benefit of treatment with curative intent for men with localised poorly differentiated prostate cancer (PCa). Objective: To evaluate relative survival in men with potentially curable PCa in relation to Gleason score (GS) and treatment as practiced in the community at large. Design, setting, and participants: A population-based study inclu
Purpose: We compared the rates of febrile urinary tract infection, kidney damage and reflux resolution in children with vesicoureteral reflux treated in 3 ways, including antibiotic prophylaxis, endoscopic therapy and surveillance with antibiotics only for symptomatic urinary tract infection. Materials and Methods: Children 1 to younger than 2 years with grade reflux were recruited into this prosp
A Summary In a large cohort of elderly women followed for 10 years, we found that balance, gait speed, and self-reported history of fall independently predicted fracture. These clinical risk factors are easily evaluated and therefore advantageous in a clinical setting. They would improve fracture risk assessment and thereby also fracture prevention. Introduction The aim of this study was to identi
The most expensive component in a conventional solar photovoltaic (PV) system is the solar module cell. The module cost could be reduced if low-cost reflector materials are used to concentrate solar energy flux across a small module area. Three reflector materials were studied for fill-factor improvements in low concentrating system. These were anodized aluminium, rolled aluminium foil and miro re
Abstract In today's western society the self-help culture is widespread. It consist of varies of medias: from courses and tv-programs, to articles in papers and magazines and entire books. The aim of many of the self-help books is to help heterosexual couples with problems in their love-life. These books have a large number of readers and are sold in millions of copies around the entire weste
The aim of this study has been to investigate the nurses’ perception of their work situation in home- help service for the elderly. We focused our study on the relationship the nurses have to their supervisor, colleagues and their patients and the influences these have on the nurses’ job satisfaction. Furthermore we wanted to learn the nurses’ view on their role as a nurse. We used a qualitative b
This report is a part of the course fire safety evaluation at Lund Univeristy and constitutes an evaluation of the security from a human safety point of view in case of fire at Kvarnbergsskolan on Värmdö. A visit to the school has been made, where the premises were documented and the existing fire protection was studied. Demarcations were done, and then the worst plausible fire scenarios were asse
In this study, two experiments were conducted to evaluate the impact of substrate concentrations on methane potential and degradation kinetics of substrate. The biochemical methane potential (BMP) tests in Experiment I were performed at a constant inoculum to substrate ratio (ISR), whereas, different ISRs were applied in Experiment II. Results obtained from Experiment I revealed that methane poten
Aims. The aim of this paper is to explore and map the age and abundance structure of the stars in the nearby Galactic disk. Methods. We have conducted a high-resolution spectroscopic study of 714 F and G dwarf and subgiant stars in the Solar neighbourhood. The star sample has been kinematically selected to trace the Galactic thin and thick disks to their extremes, the metal-rich stellar halo, sub-
