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The response of childhood acute lymphoblastic leukemia (ALL) to dexamethasone predicts the long-term remission outcome. To explore the mechanisms of dexamethasone resistance in B cell ALL (B-ALL), we generated dexamethasone-resistant clones by prolonged treatment with dexamethasone. Using RNA-sequencing and high-throughput screening, we found that dexamethasone-resistant cells are dependent on rec
Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic associations with HF in a large national biobank, and assessed whether refined phenotypic classification would facilitate genetic discovery. Methods: We defined all-cause HF among 488 010 parti
Background: In clinical research information can be retrieved through various sources. The aim is to evaluate the agreement between answers in patient questionnaires and clinical reports in a study of patients after radical prostatectomy and patient characteristics associated with agreement between these two data sources. Methods: In the prospective non-randomized longitudinal trial LAParoscopic P
A self-expanding esophageal nitinol stent was implanted under fluoroscopic guidance in 40 patients with malignant esophageal strictures and clinically significant dysphagia. The strictures were caused by squamous cell carcinoma (n = 14), adenocarcinoma (n = 12), recurrent anastomotic carcinoma (n = 8), and mediastinal tumors (n = 6). Eight stents were balloon dilated to maximum diameter immediatel
Quantified electroencephalographic activity (EEG) has been used to study normal ageing and dementia. Few studies have described longitudinal changes in the very old. A cognitive decline has been described in subjects with white-matter lesions and hypertension but the association with hypotension is unclear. Our aim was to study the predictive value of quantified EEG for the development of cognitiv
The selectivity of preparations of α-chymotrypsin immobilized on Celite or polyamide and carrying out syntheses of di- and tripeptides in acetonitrile medium were studied. The study concerns the effect of mass- transfer limitations on three different kinds of selectivity: acyl donor, stereo- and nucleophile selectivities, defined respectively as the ratio of initial rates with different acyl donor
Systemic kainic acid administration in rats induces acute limbic status epilepticus and subsequent neuronal degeneration and development of chronic hyperexcitability with similarities to human temporal lobe epilepsy. The mechanisms mediating the responses to kainic acid likely involve transcriptional changes in genes of importance for cellular injury, protection, and plasticity. We have used an ar
The transport sector accounts for large proportions of greenhouse gas emissions and energy usage in Sweden, about 40% and 30%, respectively. Most of this, 93%, comes from road transports. There is, therefore, a strong political desire to reduce the use of fossil fuels in road transport. Several alternatives to fossil fuels have been discussed and, more recently, interest in electrically driven veh
Biodegradation is becoming an attractive mode of operation for eliminating toxic chemicals released from industrial processes or already present in the environment. One needs, however, not only to identify organisms capable of degrading such chemicals, but also to address the issue of whether these chemicals, after being degraded, will be toxic to the degrading organisms if present in high concent
Popular Abstract in Swedish Denna avhandling visar att jordgubbar innehåller ett allergen, proteinet Fra a 1, som är mycket likt det allergen som orsakar besvär vid björkpollen-allergi. Den som får allergiska besvär av jordgubbar, t.ex. att det kliar och blir irriterat i munhålan och svalget när man äter , har ofta en björkpollen-allergi sen tidigare. Motsvarande allergen finns också i en del andrStrawberry (Fragaria ananassa) is an economically important crop, and recognised as an important source of antioxidants and bioactive compounds with health promoting effects. Yet increased incidence of allergy puts a limit to the choice of food for an increasing percentage of the population. As part of this thesis a strawberry allergen termed Fra a 1 was identified, which is related to a major bi
Popular Abstract in Swedish Inom sjukvården används strålning för att behandla cancer. Vid strålbehandling är det viktigt att man i förväg vet precis hur strålningen ska ges till patienten för att resultatet av behandlingen skall bli bra. Ett hjälpmedel som används för detta är ett datorprogram (dosplaneringssystem) som, med utgångspunkt från patientens anatomi, beräknar hur varje enskild patient Gel dosimetry is a new dosimetry method applied in radiation therapy. Gel dosimeters consist of a radiation sensitive gel, which can integrate absorbed doses from several radiation sources or beams. The dose to the gel can be evaluated by magnetic resonance imaging (MRI), a procedure that is the focus of the present thesis. A robust tool for the evaluation of the nonuniformity in MRI has been dev
Myosin light-chain phosphorylation is the primary mechanism for activating smooth-muscle contraction and occurs principally at Ser-19 of the 20 kDa light chains of myosin (LC(20)). In some circumstances, Thr-18 phosphorylation may also occur. Protein kinase C (PKC) can regulate LC(20) phosphorylation indirectly via signalling pathways leading to inhibition of myosin light-chain phosphatase. The go
The aim of the study was to test the hypothesis that the presence of a ventriculoperitoneal shunt ( VPS) influences the frequency of postoperative complications after video-assisted gastrostomy ( VAG) in children. When using a power of 80%, a critical value for significance of 5% and an assumed population-based standard deviation of 0.4, it will be required to have a sample size of at least 14 chi
Selective pressurized liquid extraction (PLE) of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) from various food and feed samples was performed with a selective PLE method previously developed for bulk PCBs. The method utilizes sulfuric acid impregnated silica inside the extraction cell to oxidize coextracted fat. Extractions were per
OBJECTIVE. To study treatment of hypertension in pregnancy in Sweden and compare our results with a similar study published in 1981. METHODS. A multiple choice questionnaire was sent to 92 obstetricians throughout Sweden and 88% responded. RESULTS. Most Swedish obstetricians would treat a woman in the second trimester with blood pressure 140/95 mmHg without antihypertensive medication (83%) in the
Hydrophobic interaction chromatography (HIC) and other capture media are typically produced by grafting different ligands to base matrices at defined surface densities. This often complicates media production. An alternative approach to media involving in situ radical initiated polymerization was used to graft polymer coatings directly at Sepharose(D polymeric base matrices. This method appears su
Liquid solubility measurements were performed by immersion of poly(octyl)methylsiloxane (POMS) in dilute aqueous solutions of homologous series of aliphatic esters and alcohols with compound specific concentrations of 20, 40, 80 and 120 ppm. Measurements were performed at 20 °C with both single- and multi-compound mixtures and linear sorption isotherms were obtained. By fitting experimentally dete
