Filtyp
Background. Goodpasture's disease (GP) is a rare but severe disease characterized by anti-glomerular basement membrane antibodies, rapidly progressive glomerulonephritis and lung haemorrhage. The autoantibodies are restricted to a narrow epitope region on the NC1 domain of the alpha3 chain of type IV collagen. GP is strongly associated with major histocompatibility complex (MHC) allele HLA DRB1-15
This study describes, in quantitative terms, the effects of endothelin-2 and endothelin-3 on vascular tone (resistance) in large-bore arterial resistance vessels (> 25 microns), small arterioles (< 25 microns) and the veins, as well as on capillary pressure and fluid exchange in cat gastrocnemius muscle in vivo. Infusion of endothelin-2 or endothelin-3 (200-1600 ng kg-1 min-1, i.a.) elicited an in
The main aim of this thesis is to reach a deeper understanding of how personality and core beliefs relate to the experience of quality of life in old age, with regard to shaping meaning and worth. The thesis has been developed using a dialogue with older person’s reality, as it is lived in daily life. The thesis includes four studies. Quantitative as well as qualitative methods were used for analy
In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the first study, children with Ph-positive chronic myeloid leukemia (CML) were found to have essentially the same breakpoint locations in BCR as adults, a pattern which differs from the one seen in Ph-positiv
Popular Abstract in Swedish Sammanfattning Den här avhandlingen handlar om gränsskiktet mellan nanoteknologi och cellbiologi, om hur celler och nanostrukturer påverkar varandra, och om hur man kan använda nanopinnar för att studera celler. Å ena sidan vill man kunna mäta egenskaper hos cellerna, det vill säga låta cellerna påverka pinnarna, å andra sidan vill man kunna styra cellerna – låta pinnarThis study explores the interaction between living biological cells and semiconductor nanowires. Biological cells are highly complex and dynamic entities, every one of them with individual characteristics and a high degree of internal and external communication. They respond to and affect their external environment with a huge web of fine-tuned control systems. Traditional biochemical tools for
Significant faunal changes reported fromrecent, coastal environments,which are not directly influenced by urban and industrial impact, are rarely seen. In Gullmar Fjord on the Swedish west coast, a significant foraminiferal fauna change occurred in connectionwith severe low-oxygen conditions that evolved in thewinter of 1979/1980. A foraminiferal fauna marked by common Skagerrak–Kattegat species,
Popular Abstract in Swedish Från mitten av 1970-talet utvecklades i Sverige en ny form av behandling för missbrukare av narkotika och alkohol: Miljöterapi med psykoterapi. Miljöterapin innebar en längre tids drogfri vistelse på behandlingshem där ett konstruktivt, bejakande och människovärdigt klimat avsågs vara behandlande dygnet runt. Psykoterapin var i regel schemalagd transaktionsanalytisk (TAThis monograph studies the outcomes of transactional analysis (TA) psychotherapy with addicts of heavy drugs in long time residential treatment (one year or more) at Swedish therapeutic communities (TCs) during the 1990s. Two sets of data were obtained: The primary material concerned results of approximately one year of TA-therapy; the secondary specific TA-therapy results versus total mileau ther
OBJECTIVES: To evaluate the outcome of treatment for deep sternal wound infection (DSWI) in a nationwide patient cohort, before and after the introduction of negative-pressure wound therapy (NPWT). METHODS: This was a population-based cohort of all patients treated for DSWI in Iceland out of 2446 open heart operations performed between 2000 and 2010. Length of hospital stay, survival and reoperati
TnBgl1A from the thermophile Thermotoga neapolitana is a dimeric beta-glucosidase that belongs to glycoside hydrolase family 1 (GH1), with hydrolytic activity through the retaining mechanism, and a broad substrate specificity acting on beta-1,4-, beta-1,3- and beta-1,6-linkages over a range of glyco-oligosaccharides. Three variants of the enzyme (TnBgl1A_E349G, TnBgl1A_E349A and TnBgl1A_E349S), mu
The present study aimed to investigate the effects of separate and simultaneous dietary intake of atorvastatin (ATO) and the soluble fiber oat bran on serum and hepatic lipid levels and the degree of atherosclerosis. Ninety female LDL-receptor-deficient (LDLr-/-) mice were fed a Western-type diet containing either low dose (0.0025%), high dose (0.01%) or no ATO, with or without oat bran (27%) (n =
Size distribution measurements performed at five different stations have been investigated during a one-year period between 01 June 2000 and 31 May 2001 with focus on diurnal, seasonal and geographical differences of size distribution properties. The stations involved cover a large geographical area ranging from the Finnish Lapland (67degrees N) down to southern Sweden (56degrees N) in the order V
In this work, we reconstructed in vitro the behavior of two motor proteins-myosin and actin-responsible for the mechanical action of muscle cells. By transferring this in vivo system to an artificial environment, we were able to study the interaction between the proteins in more detail, as well as investigating the central mechanism of force production. Nm-patterning by e-beam lithography (EBL) co
Rat dopamine D(2short) expressed in Chinese hamster ovary (CHO) cells were characterized by means of activation of [(35)S]-guanosine 5'-O-(gamma-thiotriphosphate) ([(35)S]GTPgammaS) binding and inhibition of [(3)H]raclopride binding. Among 18 dopaminergic ligands studied dopamine, NPA, apomorphine and quinpirole were full agonists in activation of [(35)S]GTPgammaS binding, while seven ligands were
Bacterial endotoxins (BEs) are integrated part of Escherichia coli, a microorganism widely used for the production of recombinant proteins. BEs should be eliminated in the course of down stream processing of target protein produced by these bacteria. Supermacroporous monolith (continuous bed) columns, so called cryogel columns, with immobilized polyethyleneimine (PEI), polymyxin B (PMB) and lysozy
Measurements of the adiabatic laminar burning velocities of n-heptane, iso-octane, ethanol and their binary and tertiary mixtures are reported. Non-stretched flames were stabilized on a perforated plate burner at 1 atm. The Heat Flux method was used to determine burning velocities under conditions when the net heat loss from the flame to the burner is zero. Initial temperatures of the gas mixtures
Five patients with rheumatoid arthritis or osteoarthrosis of the wrist joint were followed up for 15 ( 14 - 17) years after wrist-joint arthroplasty with semiconstrained artificial joint mechanisms that had been anchored to bone using the osseointegration principle. They were fixed by one titanium screw introduced into the radius, and two or more titanium screws introduced distally into the metaca
The aim of the study was to evaluate the influence of a-ketoglutarate (AKG), at pH 2 or 5, combined with vitamin B-6 (AKG 2B, AKG 5B) or C (AKG 2C, AKG 5C), on the performance and haemoglobin and amino acid levels in growing rats. Eighty rats were divided into 5 treatment groups and stayed on trial for 9 d (n=16) or 18 d (n=10). No significant differences in average daily gain (ADG), average daily
The prevalence of diabetic retinopathy and the associated medical risk factors, such as age at onset and duration of diabetes, metabolic control, blood pressure, albumin clearance and serum creatinine, were studied in 501 patients with type I diabetes mellitus. The prevalence of retinopathy, characterized as simplex, maculopathy, preproliferative, and proliferative, was 60.5%. Patients with retino
