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Objective- Revealing patterns of associations between circulating protein and lipid levels could improve biological understanding of cardiovascular disease (CVD). In this study, we investigated the associations between proteins related to CVD and triglyceride (TG), total cholesterol, LDL (low-density lipoprotein), and HDL (high-density lipoprotein) cholesterol levels in individuals from the genera
Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal.Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomiz
The aim of this paper is to explore the relationship between spatial-temporal patterns of vehicles types and numbers in different urban functional zones and traffic-related air pollutant emissions with real-time traffic data collected from traffic surveillance video and image recognition. The data were analyzed by using video-based detection technique, while the air pollution was quantified via po
Det ökande byggandet av stadsvägtunnlar, de alpina tunnelolyckorna runt millennieskiftet, och det efterföljande EU-direktiv (2004/54/EC) med minimikrav gällande brandsäkerhet har placerat brandsäkerhet i vägtunnlar högt på dagordningen. Samtidigt är moderna enkelriktade vägtunnlar ofta bland de säkraste delarna av vägsystemet. Har vi kommit till en punkt där resurserna används bättre någon annanstThis thesis can be described as a journey in performance-based fire safety design. Along the way questions such as what fire safety is, how it can be measured, whether we are posing the right questions, or engineer the best solutions, have arisen. The safety journey naturally started out with the traditional view, with fire safety engineering based on limit-based design. Using this paradigm the sa
Bakgrund: Considerable differences exist among the living donor Kidney Exchange Programmes (KEPs) that are in use and being built in Europe, contributing to a variation in the number of living donor transplants [6]. Efforts of European KEPs to exchange (best) practices and share approaches to address challenges have, however, been limited.Methods: Experts from 23 European countries, collaborating
Background: Emerging literature suggests that boredom is a frequent problem experienced by homeless persons that may influence their health and well-being. Purpose: The range and breadth of literature exploring boredom among homeless persons is unknown. We initiated this study to fill this gap in existing literature. Method: Using the method advanced by Arksey and O’Malley (2005), and furthered by
Alongside harm avoidance, incompleteness and disgust have been proposed as important emotion-related motivators underlying the symptoms of obsessive-compulsive disorder (OCD). The aim of the present study was to investigate the validity of self-report and interview-based measures of these constructs in youth with OCD (N=100) and anxiety disorders (N=96). All participants completed self-report meas
Aims of the study: Neurological impairment after resuscitated cardiac arrest (CA) remains a significant unmet medical need. Brain ischemia associated with CA and subsequent reperfusion is evident as two fundamentally different types of damage on neuropathological examination: frank necrosis (involving all cell types) and selective eosinophilic neuronal death (SEND). These types of damage are not o
BACKGROUND: Advanced glycation end product is an established risk marker in diabetic vascular disease, but its possible associations with atherosclerosis in a general population are yet to be investigated. We studied the degree of carotid atherosclerosis and its association with skin autofluorescence in an elderly population.METHODS: Carotid ultrasound and skin autofluorescence measurements were p
The androgen insensitivity syndrome is a disorder caused by deficient function of the androgen receptor, characterized by varying degrees of undermasculinization in karyotypic males. We have identified four mutations in the androgen receptor gene, in the region encoding the DNA-binding domain of the protein. Two mutations, R607X and R615G, were found in patients with complete insensitivity to andr
It is unclear how to address PTSD in the context of chronic pain management. Here we examine the potential benefits of an addition of prolonged exposure (PE) therapy for PTSD for adults attending multidisciplinary CBT for chronic pain. Four adults seeking treatment for chronic pain from a specialized pain rehabilitation service were offered PE for PTSD using a replicated, randomized, single-case e
Introduction: Gallbladder carcinoma is about 0.5% of all cancer. The outcome of patients with gallbladder carcinoma is overall bad and the only potentially curative treatment is surgery. The aim of this study was to determine the disease's prevalence in Iceland and outcome of the patients diagnosed in the study period.Patients and methods: This was a retrospective study of all diagnosed patients w
Gambierdiscus and Fukuyoa are genera of toxic dinoflagellates which were mainly considered as endemic to marine intertropical areas, and that are well known as producers of ciguatoxins (CTXs) and maitotoxins (MTXs). Ciguatera poisoning (CP) is a human poisoning occurring after the consumption of fish or more rarely, shellfish containing CTXs. The presence of these microalgae in a coastal area is a
Purpose: Hodgkin lymphoma (HL) survivors are known to have increased cardiac mortality and morbidity. The risk of developing cardiovascular disease after involved node radiotherapy (INRT) is currently unresolved, inasmuch as present clinical data are derived from patients treated with the outdated mantle field (MF) technique. Methods and Materials: We included all adolescents and young adults with
Cognitive screening has been proposed for older adults diagnosed with chronic obstructive pulmonary disease (COPD). Therefore, we examined the change over time in cognitive function and the risk of incident dementia in older adults after COPD diagnosis. A sample of 3,982 participants from the population-based cohort study Good Aging in Skåne was followed for 19 years, and 317 incident COPD cases w
The majority of the single-family houses in Sweden are affected by deteriorations in building envelopes as well as heating, ventilation and air conditioning systems. These dwellings are, therefore, in need of extensive renovation, which provides an excellent opportunity to install renewable energy supply systems to reduce the total energy consumption. The high investment costs of the renewable ene
