Sökresultat

Creation and adoption of corporate policies requires significant commitment of scarce senior management resources. In the absence of processes and tools, convergence upon final policy and may not be achieved in a timely manner. Significant similarities between policy and requirements documents suggest that requirements engineering techniques could be used to generate policy. However, neither evide

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING (Popularized summary in Swedish) Alkohol inta's för sina effekter på hjärnan och ger upphov till välbehagskänslor och berusning. Alkoholmissbruk är dock skadligt för hjärncellerna. När alkoholmissbruket dessutom är för långvarigt, uppstår förändringar i hjärnan, som avser att kompensera för alkoholeffekten, vilket medför att alkohol m

Popular Abstract in Swedish Det finns ett ökat intresse för behandling med talidomid. Därför var målsättningen med detta avhandlingsarbete att åstadkomma en mer ändamålsenlig användning. Några kemiska och farmakologiska aspekter med speciell inriktning på omsättningen av talidomid i människokroppen studerades. Historien om talidomid (Neurosedyn; varumärke i Sverige) är ett tragiskt kapitel i läkeThalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. Given this renewed interest the aim of this thesis was to achieve a more rational use of thalidomide. Therefore some c

Popular Abstract in Swedish I Fornstora dagar, moderna tider är perspektivet vidare än i traditionellt historiografiska studier. De bruk och debatter som analyseras begränsas inte till de historievetenskapliga historieprodukterna. Studien visar att kring sekelskiftet 1900 dominerade det nationalistiska historiebruket. Under mellankrigstiden var såväl traditionella som moderna perspektiv väl represThe aim of the study is to investigate uses of and debates on Swedish history during a period of 100 years. The perspective is broader than the traditional study of history, since it supplements the search for new facts, contexts and interpretations by which meaning is ascribed the the past by different producers and consumers of history in society. The dominating use of history around 1900 was id

The aims of this study have been focused on the identification of cell surface structures involved in the induction and regulation of apoptosis. Monoclonal antibodies against the major histocompatibility complex class I (MHC-I) were shown to induce apoptosis when cross-linked on the cell surface of different malignant cells having a pre-B or a myeloid precursor phenotype. The apoptotic response wa

The study explored the utility of four-point preprandial glucose self-monitoring to calculate several indices of glycemic control and variability in a study adding the DPP-4 inhibitor vildagliptin to ongoing insulin therapy. This analysis utilized data from a double-blind, randomized, placebo-controlled crossover study in 29 patients with type 2 diabetes treated with vildagliptin or placebo on top

Background. Systemic sclerosis (SSc) is an autoimmune disease where thickening of the skin can lead to reduced body function and limitations in activities. Severe forms can also affect and seriously damage inner organs. Patient-centred rehabilitation emphasises considerations of patients' background, experience and behavior which highlights the need to know if patient-reported outcome measures (PR

Objective. Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. Methods. We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. Results. In total, 63 epit

Phytase (EC 3.1.3.-) hydrolyzes phytate (IP6) present in cereals and grains to release inorganic phosphate (Pi), thereby making it bioavailable. The most commonly used method to assay phytase, developed nearly a century ago, measures the Pi liberated from IP6. This traditional end point assay is time consuming and well known for its cumbersomeness in addition to requiring extra caution for handlin

Background. Comparisons of different stakeholders' ratings of the quality of older people care can help to drive quality improvement. Aim. The aim was to compare staff, older care recipients' and their relatives' quality of care ratings. Design. Cross-sectional questionnaire surveys in 2003 and 2004, using a repeated measures design on an organizational level. Methods. Nursing staff, care recip

Neurobiological markers in cerebrospinal fluid (CSF) and in serum, previously found to co-vary with destructive personality traits in violent offenders, were explored in a general population sample of 21 patients undergoing knee surgery. Results on the Karolinska Scales of Personality (KSP) and the Temperament and Character Inventory (TCI) were compared with CSF/serum albumin ratios and serum conc

We report on the performance of the third-order Douglas–Kroll ab initio model potential (DK3-AIMP) method-based electron-correlated spin–orbit calculations. Our treatment assumes that the problem can be separated into a spin–free correlation treatment and a spin–orbit calculation. The correlation effects were calculated using the multistate complete active space second-order perturbation method, a

Aim: The aim of this study was to study the type and frequency of complications and change in weight after a laparoscopic gastrostomy procedure in 31 children with congenital heart disease, comparing patient groups of children with univentricular and biventricular circulation, and with completed and uncompleted cardiac surgery. Methods: The method used was that of a retrospective study of all 31 c

Background: A DGGE-based assay for hepatitis B virus (HBV) drug-resistance monitoring was designed and checked for feasibility. It detects mutations within the YMDD motif related to lamivudine resistance. Material/Methods: The YMDD motif of HBV polymerase was amplified by the set of primers designed in this study. DGGE analysis of the amplicons was performed on 9% polyacrylamide gels containing a

Trichoderma reesei produces five known endoglucanases. The most studied are Cel7B (EG I) and Cel5A (EG II) which are the most abundant of the endoglucanases. We have performed a characterisation of the enzymatic properties of the less well-studied endoglucanases Cel12A (EG III), Cel45A (EG V) and the catalytic core of Cel45A. For comparison, Cel5A and Cel7B were included in the study. Adsorption s

There is a need for a deeper understanding of and discussion about different cultures' influences on life-views and ethical reasoning among professionals within healthcare. A culture can be seen as a set of guidelines, both explicit and implicit, which individuals inherit as members of a particular society, and which tells them how to view the world and how to behave in it in relation to other peo

Abstract Bacterial diversity in the microbial communities of posterior gut sections of three temperate marine herbivorous fish species from New Zealand was characterised using Amplified Ribosomal DNA Restriction Analysis, and 16S rRNA gene amplification and sequencing methods. The fish were collected in 1999–2000 in the Hauraki Gulf, New Zealand (35°54’–36°24’S, 174°48’–175°25’E). The gastrointest

Polarization spectroscopy in the mid-infrared (IRPS) has been applied to the detection of acetylene molecules making use of the asymmetric C-H stretching vibration at around 3 μm. The infrared laser pulses were produced through difference frequency generation in a LiNbO₃ crystal pumped by a Nd:YAG and dye laser system. By directly probing the ro-vibrational transitions with IRPS, sensit

Wilms tumor is the most frequent renal neoplasm in children, but our understanding of its genetic basis is still limited. We performed cDNA microarray experiments using 63 primary Wilms tumors with the aim of detecting new candidate genes associated with malignancy grade and tumor progression. All tumors had received preoperative chemotherapy as mandated by the SIOP protocol, which sets this study