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Joubert syndrome and related disorders (JSRD) are clinically and genetically heterogeneous ciliopathies sharing a peculiar midbrain-hindbrain malformation known as the 'molar tooth sign'. To date, 19 causative genes have been identified, all coding for proteins of the primary cilium. There is clinical and genetic overlap with other ciliopathies, in particular with Meckel syndrome (MKS), that is al
Adsorption onto hydrophobic surfaces of α-, β-, γ-, and ω-gliadins from the wheat variety Chinese Spring was studied by means of in situ ellipsometry. Most measurements were conducted in 0·01m phosphate buffer, pH 6·0, with the protein concentrations 1, 5 and 25 μg/mL. The adsorbed amount varied between 1·3 and 11·4 mg/m2, which is high considering the low protein concentrations. The concentration
INTRODUCTION: Not only repolarization, but also depolarization ECG indexes reflect the progression of ischemic injury. The aim was to assess the QRS duration and morphology dynamics during the prolonged coronary occlusion and their association with the myocardial area at risk (MaR) and final infarct size (IS).METHODS: In pigs, myocardial infarction was induced by inflation of an angioplasty balloo
New Public Management (NPM) was the catch phrase of the reforms in the public research and higher education sector for the last decades. The postulated effect of the NPM reforms is increased efficiency in governmental resource spending on the public higher education and research institutions. Though backed by theoretical considerations, this hypothesis has hardly been tested empirically. Using a u
Are anti-vibration gloves the solution to the problem of hand-arm vibration?Vibrations from hand-held machinery are a major problem in the Swedish labour force. In 2009, 14% of men and 3% of women of employed in Sweden reported exposure to hand-arm vibration at least a quarter of their working time according to the Swedish Work Environment Authority (Arbetsmiljöverket 2010). It is tempting to imag
Background/Objectives:Obesity and low physical fitness are known risk factors for ischemic heart disease (IHD), but their interactive effects are unclear. Elucidation of interactions between these common, modifiable risk factors may help inform more effective preventive strategies. We examined interactive effects of obesity, aerobic fitness and muscular strength in late adolescence on risk of IHD
Bolger C, Tufvesson E, Anderson SD, Devereux G, Ayres JG, Bjermer L, Sue-Chu M, Kippelen P. Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes. J Appl Physiol 111: 1059-1065, 2011. First published July 28, 2011; doi:10.1152/japplphysiol.00113.2011.-Injury to the airway epithelium has been proposed as a key susceptibility factor for exercis
The present study employs square cross-section ribbed channels with different arrangements of downstream half-size ribs to determine the most optimal configurations for augmenting heat transfer rates with minimized pressure drop penalties. The channel inlet Reynolds number ranges from 20,000 to 160,000. The influence of downstream ribs arrangement on the overall performance characteristics of ribb
At the turn of the nineteenth century, most men wore suits. One easily gets the impression that all these men look more or less identical; the suits seem to resemble uniforms. Furthermore, compared to the women’s clothing of the period, the suit seems restrained and even drab in its shape and colour. The dissertation takes up this point and examines the claim that all men look alike in a suit. The
Introduction: We conducted a prospective observational study in cardiac arrest survivors treated with mild induced hypothermia, evaluating different platelet function tests at hypo-and normothermia. We also investigated the relation between gastric emptying and vasodilator stimulated phosphoprotein (VASP). Methods: Comatose survivors of out of hospital cardiac arrest were included and divided into
Objectives. To study possible nerve regeneration of a damaged auditory nerve by the use of stem cell transplantation. Methods. We transplanted HNPCs to the rat AN trunk by the internal auditory meatus (IAM). Furthermore, we studied if addition of BDNF affects survival and phenotypic differentiation of the grafted HNPCs. A bioactive nanofiber gel (PA gel), in selected groups mixed with BDNF, was ap
Popular Abstract in Swedish Intag av födoämnesantigen resulterar normalt i induktion av oral tolerans, men klinisk och immunologisk betydelse av kortvarig neonatal exponering för komjölksproteiner är inte klarlagt. Syftet med detta arbete var att studera prospektivt effekten av olika uppfödningsregimen under de tre första levnadsdagarna. Påverkan på makromolekylär absorption, antikropps produktion
New high-efficiency power cycles and environmentally friendly cycles have introduced combustion atmospheres that differ from the traditional hydrocarbon-air mixtures. Wet cycles, solid oxide fuel cell with a gas turbine (SOFC-GT), CO2 separation/capture and biogas combustion are processes that involve high concentrations of inert gases such as H 2O, CO2 and N2
The effects of five different meat raw materials used for making beefburgers on the evolution of mass transfer (total, water and fat losses), patty diameter shrinkage and porosity were studied during frying from the frozen state (-20 degrees C) to a centre temperature of 72 degrees C in a double-sided pan fryer. The normalised water losses increased linearly with increasing average temperature at
In the work presented in the thesis laser diagnostics was employed primarily in the investigation of engines, but was also used to study soot in flames. Quantitative measurements were performed for visualizing both in-cylinder soot formation and DME sprays in a combustion vessel. The DME sprays inside a diesel truck engine were also qualitatively investigated. The combustion process in the HCCI en
The adsorption of modified polyacrylamides (PAM) at the silica surface has been studied by ellipsometry. To study the influence of the type of modification of the polyacrylamide on the adsorption behaviour, we have used cationic, anionic and hydrophobically modified polyacrylamides with varying charge density and degree of hydrophobisation. The adsorbed amount and adsorbed layer thickness were obt
P>The coordination of swallowing and respiration is essential for a safe swallow. Swallowing consists of several subsecond events. To study this, it is important to use modalities with high temporal resolution. In this study, we have examined young healthy individuals with simultaneous videofluoroscopy, videomanometry and respiratory recording, all with high temporal resolution. The onset of 13 pr
A localized dehydration zone, Sondrum stone quarry, Halmstad, SW Sweden, consists of a central, 1 m wide granitic pegmatoid dyke, on either side of which extends a 2.5-3 m wide dehydration zone (650-700 degrees C; 800 MPa; orthopyroxene-clinopyroxene-biotite-amphibole-garnet) overprinting a local migmatized granitic gneiss (amphibole-biotite-garnet). Whole-rock chemistry indicates that dehydration
Objective: Two patients who suffered acute failure of their St Jude Medical Masters aortic valve prostheses due to leaflet arrest that were unrelated to suture material are presented. It was hypothesized that the valves failed because force applied to bear upon the valve annulus caused the hinge mechanism to become restricted or to arrest. Methods: A study was designed to measure the force that wo
