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Purpose: High-risk colon cancer may benefit from preoperative chemotherapy (preCHT), but evidence on its short-term safety and outcome is limited. Population-based evidence before its incorporation into national guidelines is lacking. Methods: Patients with final weighted stage II–III colon cancer undergoing elective resection between 2007 and 2017 were identified in the Swedish Colorectal Cancer
Background: The European ALLTogether protocol for childhood acute lymphoblastic leukemia, initiated in Sweden 2019, introduced earlier asparaginase during induction, dexamethasone instead of prednisone for all patients, and omitted anthracyclines from low-risk induction to reduce treatment-related toxicity. Consolidation-1 was based on the Induction 1B-phase developed by the BFM-group, replacing m
Weight stigma negatively impacts people with higher weights across the lifespan as well as social contexts and can lead to weight discrimination. As weight is not a protected identity in Canadian human rights legislation, it is important to better understand how weight discrimination is being argued in Canada’s legal system. The purpose of this environmental scan was to examine and describe Canadi
Aim: To investigate the prevalence of eating and drinking difficulties as classified with the Eating and Drinking Ability Classification System (EDACS) in a large population-based cohort of children with cerebral palsy (CP) at all levels of motor function, and how EDACS classifications relate to undernutrition. Method: This was a cross-sectional study based on data from the Swedish CP follow-up pr
To improve the shelf-life of food products rich in lipids, it is important to minimize the lipid oxidation that occurs during processing, since this oxidation not only decreases shelf-life but also induces off-flavors. To evaluate the oxidation of lipids in the production of one β-glucan-rich and one protein-rich food supplement made from oats (Avena sativa), the neutral and polar lipid profile, h
Background and purpose — Limited research has been conducted on basicervical femoral neck fractures (bFNFs). The importance of displacement in clinical outcomes remains unclear. We aimed to characterize patient demographics, degree of displacement, treatment, treatment failures, and reoperations in a cohort of fractures from the Swedish Fracture Register (SFR). Methods — 1,260 fractures in 1,185 i
Background: Food biodiversity in human diets has potential co-benefits for both public health and sustainable food systems. However, current evidence on the potential relationship between food biodiversity and cancer risk, and particularly gastrointestinal cancers typically related to diet, remains limited. This study evaluated how dietary species richness (DSR) was associated with gastrointestina
Background: Circulating dietary biomarkers are not direct proxies for intake, as the biomarkers reflect not only food and supplement consumption but also nutrient absorption, metabolism, and tissue distribution. Therefore, along with nutrient intake, several other upstream factors can impact dietary biomarker concentrations, including demographic, medical history, and genetic factors. Objectives:
Introduction: The adverse health effects of sugar-sweetened beverage intake are well-established, but the implications of overall added sugar intake remain unclear. We investigated the associations between intake of added sugar and various sugar-sweetened foods and beverages and risk of 7 cardiovascular diseases in 69,705 participants aged 45–83 years (47.2% female) from the Swedish Mammography co
The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac xenotransplantation. However, it is still unclear which single antibody directed against CD40 or CD40L (CD154), or which combination of antibodies, is better at preventing organ rejection. For example, the high doses of antibody administered in previous experiments might not be feasible for the treatment of humans
Background Major intrinsic proteins (MIPs) also named aquaporins form channels that facilitate the passive transport of water and/or other small polar but uncharged molecules across membranes. MIPs are particularly abundant and diversified in terrestrial plants but little is known about their evolutionary history. In order to shed light upon the origin of the plant MIP subfamilies 9 algal genomes
In 2012, there were 11 000 accidents and near-miss reported of which most of it can be prevented. Though reporting and investigating injuries present a more detailed picture, this is still a lagging indicator — measuring after the event. Recording and investigating near misses, on the other hand, can be used as a positive indicator of performance tool to fix problems before injuries occur. Employe
We have implemented four bio-inspired selforganizing haptic systems based on proprioception on a 12 d.o.f. anthropomorphic robot hand. The four systems differ in the kind of self-organizing neural network used for clustering. For the mapping of the explored objects, one system uses a Self- Organizing Map (SOM), one uses a Growing Cell Structure (GCS), one uses a Growing Cell Structure with Deletio
Ectomycorrhiza (EM) is a symbiosis between soil living fungi and the roots of woody plants. EM fungal communities are important in forest nutrient cycling, they are species rich and their structures vary between habitats and over time. An EM community in a phosphorus-poor forest was exposed to apatite and EM mycelia actively colonizing ingrowth bags were analyzed. Internal transcribed spacer (ITS)
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING (Popularized summary in Swedish) Monoaminer Monoaminer såsom serotonin, dopamin, noradrenalin, adrenalin och histamin är alla signalsubstanser syntetiserade från enkla aminosyror. Nervceller som innehåller monoaminer är anatomiskt lokaliserade till hjärnstammen och förlängda märgen. Härifrån försörjer de resten av storhjärnan samt ryIn the present study, the mRNA encoding the serotonin transporter (5-HTT) and two isoforms of the vesicular monoamine transporters (VMAT1 and VMAT2) have been mapped in the rat throughout gestation and early postnatal development using in situ hybridization, RT PCR and immunohistochemistry. 5-HTT mRNA was found in serotonergic neurons and VMAT2 mRNA in all monoaminergic neurons from early gestatio
Objective: The primary aim of this study was to examine the association between the different predicted phenotypes of the polymorphic CYP2D6 gene and the prevalence of adverse drug reactions in patients suffering from depressive disorders. The secondary aim was to investigate if comedication with CYP2D6 inhibitors resulted in more adverse drug reactions due to phenoconversion. Methods: Between Jan
Research on personality traits predicting life outcomes has typically been investigated using the Big Five factors and only occasionally their facets. However, recent research suggests that the use of items (reflecting personality nuances) can account for more predictive variance. The aim of the present study was to examine the predictive validity for various life outcomes comparing the hierarchic
Purpose: To monitor cardiovascular health, in 2022, the American Heart Association (AHA) updated the construct “Life’s Simple 7” (LS7) to “Life’s Essential 8” (LE8). This study aims to analyze the associations and capacity of discrimination of LE8 and LS7 in relation to self-rated health (SRH) and health-related quality of life (HRQoL). Methods: This study from the Swedish CArdioPulmonary bioImage
Ataxia telangiectasia (A-T), caused by biallelic variants in the ATM gene, is a multisystemic and severe syndrome characterized by progressive ataxia, telangiectasia, hyperkinesia, immunodeficiency, increased risk of malignancy, and typically death before the age of 30. In this retrospective study we describe the phenotype of 14 pediatric and adult A-T patients evaluated at the Karolinska Universi
