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High migratory and cytotoxic capability of CD56bright NK cells in a BBB in vitro model

High Migratory and Cytotoxic Capability of CD56bright NK Cells in a Blood-Brain-Barrier in Vitro Model The blood brain barrier (BBB) is a tight structure in the Central Nervous System (CNS) that restricts the entry of immune cells. This restriction is regulated by different components such as endothelial cells, tight junction proteins and other cells such as pericytes, astrocytes and neurons. Nat

Geographic Concentration of Industry 4.0 patents in Sweden: 2010-2017

In the age of ever-growing technological advancements, delegating some of the inherently human tasks to smart machines is becoming more and more common. The possibly new wave of industrialization – Industry 4.0 – is comprised of interconnected smart technologies that could automate parts of the production and decentralize the decision-making process. The associated efficiency has prompted business

Maternal Education and Preventive Behaviour - Evidence from Zimbabwe´s Educational Reform

This paper aims to investigate the causal relationship between maternal education and preventive behaviour. For this purpose, I consider the education reform implemented in Zimbabwe in 1980 that enabled students at age 15 and below to participate in secondary education. By using this age cutoff as an exogenous exposure to the education policy, I obtain causal estimates of schooling on health outco

"[...] en stämpel, tjoff rakt i pannan, som säger att våra bäst-före-datum passerats" : En kvalitativ studie om äldres upplevelser under coronapandemin

The purpose of this study was to investigate senior citizens’ experiences of the isolation during the Coronavirus pandemic and their perspectives on their own role and identity during the same periodof time. The empirical data consisted of 15 articles which all expressed seniors’ viewpoints, published between 2020-03-16 and 2020-05-11 in ten different Swedish newspapers. The study’s methodological

A no-win situation: A case study of Socialstyrelsens brochure on child marriage and the moral outrage that followed

This study analyzes a no-win situation in which the Swedish public organization Socialstyrelsen were not able to achieve strategic goals, with the organizations mandate going against prevalent moral cultural ideals. When attempting to perform their mandate Socialstyrelsen was suddenly hit by an online firestorm, hurting their reputation and hindering them in performing their democratic responsibil

Development of Tools to Classify Poor Quality Images from High Content Screening results for Cell Death and Lysosome Studies

Cell death is an important field of biology that is linked to many other topics in medicine and biology. One of the methods to investigate cell death is through high content screening (HCS) which makes use of robotic microscopy. By this technology, cell death associated organelle membrane permeabilisation and the localisation of certain dyes can be visualised and elucidate a substantial amount of

Characterization of cellular enzymatic activity through functional single cell analysis using DropMap

Assuming normal distribution within cell populations has long been status quo in cellular research. With the fast development of techniques, numerous examples of heterogeneites within isogenic cultures have been unveiled, demonstrating the need of single cell analysis. Currently there are many widely used techniques for this, such as single cell RNA-sequencing, FACS and CyTOF, allowing high-trough

Optimizing the usability of REST API reference documentation

Med allt större efterfrågan på tillgänglig data ökar antalet REST API:er markant världen över. Varje REST API har någon form av referensdokumentation, vilket är avgörande för förståelsen samt användandet av ett API. Samtliga API-leverantörer bör således överväga optimering av referensdokumentationens användbarhet för att underlätta inlärning och användning av sin produkt. Denna masteravhandling uWith an increasingly growing demand for accessible data, the amount of REST API:s worldwide is growing. All REST API:s come with some form of reference documentation, which is crucial for the comprehension and usage of the API. Every API provider should therefore consider the usability of their reference documentation, to facilitate the learning and usage of their product. This master's thesi

Assessing the impact of urbanisation on storm water runoff peak flows in Bogotá

Översvämningar och vattenföroreningar är kopplade till försummelse av vattenhantering vid hastig urban utveckling. Om tre decennier förväntas 66% av jordens befolkning bo i städer. Hur löser vi detta? Idag bor nästan hälften av jordens befolkning i städer – en siffra som förväntas öka till mer än fem miljarder personer fram till 2030. Urbanisering anses ha stor positiv påverkan på ekonomisk tillvDue to internal conflicts and an economical conversion in the mid 1900’s, the Colombian society has seen a great social transition from rural to urbanised in the last 50 years. Apart from positive impacts of urbanisation on social factors, there are hydrological issues coupled to it. With the aim to assess the impact of urbanisation on runoff peak flows in Bogota, the historical change in impervio

Publicering av geografiska data på webben

Tid och pengar är två viktiga faktorer i dagens samhälle. Därför är det intressant att utvärdera om gratisprogram motsvarar den funktionalitet och de behov som kommersiella programvaror erbjuder i avseende på publicering av webbkartor. Väldigt många människor använder dagligen tjänster som Google Maps, Eniro och hitta.se för att skriva ut en karta, få en vägbeskrivning, visa busshållplatser, restIn most projects, there is a need to visualize geographic data in a map and in most cases, this is done in an interactive map on a computer, tablet or mobile phone. To be able to publish geographic data on the web, several components are needed. These components are in many cases purchased with a user license from a company that provides the customer with support and other user instructions. An al

En fråga om vem som beskylls i våldtäktsfall. ”Det framstår således som om hon i viss mån överdrivit det våld hon fått motta"

This study seeks to understand if and how Swedish judges use "victim blaming" in judgments of rape. In total eleven categories of "victim blaming" were included in the study and 81 cases was examined. The results show that in these 81 cases of rape "victim blaming" was present in six cases. The injured party got blamed based on their consumption of alcohol, consumptio

Approaching the New Plastic Economy: Solutions and Their Implications on Creating New Markets Around the Plastic Packaging Industry

Background: Today, plastic packages can be found from the nature all around the world, hence it is a topic which is widely discussed among consumers, the media and politics, to name a few. Furthermore, solutions to the waste issue are pondered upon these different groups. The packaging industry constitutes for a large share of the total plastic waste, which is why the study was narrowed down to th

“Titta där! Titta där! Står en riktig trollkonstnär” - En studie om att skriva musik till barn med fokus på ramar och begränsningar

Att skriva musik är något som har varit närvarande under hela mitt liv. Jag skrev min första låt när jag var åtta år och efter det har musikskapande varit en stor del av mitt musicerande. Att jobba med barn i de lägre åldrarna har också varit ett arbete som lockat mig. Jag har dock känt att jag saknar kunskap om hur barn i den åldern tar till sig musik och funderat över om sättet vi musicerar med Writing music has always been an important part of my life. I wrote my first song when I was eight years old and since then, making music has been a huge part of me as a musician. Working with children has also been something that I have found interesting but I have always felt like I did not have sufficient knowledge to do so. I have also wondered if the current way to make music for young childr

The Tale of Two Cities

Race, space and inequality are three terms deeply interlaced into social systems. South Africa provides with a good case to study the relationship between the three, due to its unique and chronologically durable employment of those terms in all enclaves of public life. Colonialism and apartheid combined, led to the extensive abuse of space and race, undermining thus the overall social welfare unde

Playa och Prekaritet - En kvalitativ studie om europeiska callcenterarbetare i Barcelona

Syftet med denna studie är att ur ett sociologiskt perspektiv undersöka hur det är att bo i Barcelona och arbeta i ett internationellt callcenter som ung europeisk medborgare. Vad är det som motiverar individer att migrera och arbeta i Barcelona? Hur upplever de förutsättningar i arbetet, social gemenskap och hur uppfattar de sin tillhörighet? Dessa frågeställningar sätts sedan i en bredare kontexThe aim of this study is from a sociological perspective understand how it is to live in Barcelona while working in an international call centre as a young European citizen. What motivates these individuals to migrate to Barcelona? What is their perspective of work, social community and notion of belonging? These questions are later to be examined together with theories of migration, modernization

"Om Nisse får 100 kronor eller 150, sådant brinner jag inte riktigt för" : En kvalitativ studie om engagemang och motivation hos socialsekreterare inom ekonomiskt bistånd

The aim of this study was to investigate what engages social workers working with social assistance and how this commitment is expressed in their everyday work. Furthermore, the focus of the study was to investigate whether conflict arises when commitment is practised in the context of organizational conditions and political structures in society. Our target group consisted of five social workers

Understanding the Effects of Novel Engineering Targets on Sugar Sensing in S. cerevisiae

Baker´s yeast S. cerevisiae has been engineered in order to enable xylose uptake and utilization from lignocellulosic biomass as this yeast cannot naturally metabolize this pentose sugar. However, xylose is not recognized as a fermentable sugar by S. cerevisiae and recent studies on the effect of xylose on the three main sugar signaling pathways (Snf3p/Rgt2p, SNF1/Mig1pt and cAMP/PKA) have indicat

A study of DGAT enzymes from Tropaeolum majus with focus on oil biosynthesis

An alternative energy and chemicals must be found to meet the future demand. A possible source of renewable energy is plant oil since it has a close chemical structure to fossil oil with less refining requirement. However, vegetable oil has not made a significant contribution to replace fossil oil as an energy source because of high demand of fossil oil. It is possible to substitute fossil-based c