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Neurotensin accelerates atherosclerosis and increases circulating levels of short-chain and saturated triglycerides

Background and aims: Obesity and type 2 diabetes are significant risk factors for atherosclerotic cardiovascular disease (CVD) worldwide, but the underlying pathophysiological links are poorly understood. Neurotensin (NT), a 13-amino-acid hormone peptide, facilitates intestinal fat absorption and contributes to obesity in mice fed a high-fat diet. Elevated levels of pro-NT (a stable NT precursor p

Trajectories of primary health care utilization : a 10-year follow-up after the Swedish Patient Choice Reform of primary health care

Background: In January 2010, the choice reform was instituted in Swedish primary health care establishing free entry for private primary health care providers and enabling patients to choose freely among primary health care centers. The motivation behind the reform was to improve access to primary care and responsiveness to patient expectations. Reform effects on health care utilization have previ

Plastic flow, structure and mechanical properties in pure Al deformed by twist extrusion

Twist extrusion (TE) is known as one of newly developed, but still moderately studied severe plastic deformation methods. This research was initiated to conduct a detailed study of structure-properties relationship evolution during TE processing. The evolution of macrostructure, Vickers hardness and tensile properties was studied in 99.99% purity aluminum during twist extrusion processing at room

The surprising utility of target drift in natural heading judgements

Gibson (1950) proposed that optic flow provides information about the direction of self-motion (heading) relative to objects in the environment. Llewellyn (1971) pointed out that the change in egocentric direction of an object, "drift", also provides information about whether an observer is passing to the left or right of the object. We compared the precision of heading judgements with flow and dr

Worse self-reported outcomes but no limitations in performance-based measures in patients with long-standing hip and groin pain compared with healthy controls

PURPOSE: This study aimed to evaluate patient-reported outcomes as well as lower extremity and trunk muscle function in patients with long-standing hip and groin pain, in comparison with matched, healthy controls. It was hypothesized that patients with long-standing hip and groin pain would report more deficiency on the Copenhagen Hip and Groin Outcome Score (HAGOS) and have worse outcomes on perf

Model for individual prediction of diabetes up to 5 years after gestational diabetes mellitus

AIMS: To identify predictors of diabetes development up to 5 years after gestational diabetes mellitus (GDM) and to develop a prediction model for individual use.METHODS: Five years after GDM, a 75-g oral glucose tolerance test (OGTT) was performed in 362 women, excluding women already diagnosed with diabetes at 1- to 2-year follow-up or later (n = 45). All but 21 women had results from follow-up

Internationalization in higher education. a description based on the results from three empirical studies

A description based on data from three empirical studies conducted with a qualitative approach in order to reveal the understanding university teachers and students, within higher education in the Swedish nursing program, had of internationalization. In Sweden, intentions of internationalization, has in a general way been discussed frequently in different educational contexts in higher education.

Voicing what? – Some reflections on Arnold Schoenberg’s Second String Quartet

The Second String Quartet by Arnold Schoenberg, written in 1907 and 1908, is breaking musical traditions at least twice – (1) by leaving tonality, (2) by breaking the genre of string quartet, adding a voice who is interpreting two poems by the German symbolist Stefan George in its third and forth movements. In this paper, I want to raise the question about the reasons why Schoenberg might have add

Temperamental diagnostics and biochemistry in suicide attempters

The aim of the present thesis was to study temperament traits and their relationships to psychiatric diagnoses, suicidal behavior and a number of biological measures in a sample of hospitalized suicide attempters. The subjects showed a bimodal distribution on the Validity scale from the Marke-Nyman Temperament (MNT) inventory, with a large subgroup showing low Validity. Cluster analyses of the sc

Identification of polymorphisms in Apolipoprotein M gene and their relationship with risk of recurrent venous thromboembolism

Apolipoprotein M (ApoM) plasma levels have been reported to be associated with risk of venous thromboembolism (VTE) recurrence. However, the role of genetic alterations in the ApoM gene in VTE recurrence remains unknown. The aim of this study was to identify genetic aberrations in ApoM gene in VTE recurrence and their role in prediction of VTE recurrence in a prospective follow-up study of 1465 VT

Antibodies against Phosphorylcholine among New Guineans Compared to Swedes : An Aspect of the Hygiene/Missing Old Friends Hypothesis

Background: We here study antibodies against phosphorylcholine (anti-PC) which we reported to be inversely associated with atherosclerosis, cardiovascular disease (CVD), and autoimmune conditions. In previous studies, we determined that this inverse association is more pronounced at low levels with high risk and at high levels, with decreased risk. We compare individuals from Kitava, New Guinea (w

Multiple alpha-galactosidases from Aspergillus niger: purification, characterization, and substrate specificities

Enzymes with α-galactosidase activity are produced by many organisms, often in multiple forms. Here we compare the biochemical and hydrolytic properties of four major α-galactosidase forms (α-gal I-IV) that were purified from the culture filtrate of Aspergillus niger. α-Gal II, III and IV appear to be isoforms of the same enzyme, and N-terminal amino acid sequence data suggest that they are closel

Brachioradial pruritus is associated with a reduction in cutaneous innervation that normalizes during the symptom-free remissions.

Background: There has been a controversy regarding the cause of brachioradial pruritus: is it caused by a nerve compression in the cervical spine or is it caused by a prolonged exposure to sunlight? Objective: The purpose was to study clinical features of patients with brachioradial pruritus and to compare the cutaneous innervation in punch biopsies from the itchy skin of patients with the age-mat

Joint capsular stiffness in knee arthritis. Relationship to intraarticular volume, hydrostatic pressures, and extensor muscle function

Increased intraarticular hydrostatic pressure (Pia) may inhibit juxtaarticular muscle function, obstruct blood supply to joint structures and promote anoxic joint destruction in chronic arthritis. Joint capsular stiffness together with synovial fluid volume determines Pia at rest. Seventeen knee joints with effusive arthritis and different degrees of radiological cartilage involvement in 13 patien

Protonation and charging of nanosized gibbsite (alpha-Al(OH)(3)) particles in aqueous suspension

Synthetic gibbsite was prepared and thoroughly characterized using X-ray diffraction, high-resolution transmission electron microscopy, atomic force microscopy, and Fourier transform infrared techniques. The protonation and charging of the particle surface(s) in 20 and 100 mM (Na)Cl ionic media were investigated using potentiometric titrations and zeta potential measurements. These measurements in

The growth of external AM fungal mycelium in sand dunes and in experimental systems

We estimated the biomass and growth of arbuscular mycorrhizal (AM) mycelium in sand dunes using signature fatty acids. Mesh bags and tubes, containing initially mycelium-free sand, were buried in the field near the roots of the dune grass Ammophila arenaria L. AM fungal mycelia were detected at a distance of about 8.5 cm from the roots after 68 days of growth by use of neutral lipid fatty acid (NL

Health-related quality of life in multiple system atrophy

Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European

Nutritional constraints on Sphagnum-growth and potential decay in northern peatlands

1 In a 4-year fertilization experiment we studied the effects of increased nitrogen (N) or phosphorus (P) supply on productivity and potential decay in the acrotelm of Sphagnum-dominated Swedish peatlands at northern (low atmospheric N input: low-N site) and southern (high atmospheric N input: high-N site) sites. 2 During the experimental period, there was a severe summer drought at the high-N sit

Lipase mediated simultaneous esterification and epoxidation of oleic acid for the production of alkylepoxystearates

Epoxy alkylstearates were synthesized by lipase catalysed esterification and perhydrolysis followed by epoxidation of oleic acid in a one-pot process. Immobilized Candida antarctica lipase (Novozym 435) was used as the catalyst. The esterification reaction occurred relatively quickly and was followed by epoxidation of the alkyl ester and the remaining fatty acid. Higher degree of esterification wa