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We previously showed that quinacrine (QC), a small molecule antimalarial agent, also presented anticancer activity in breast cancer cells through activation of p53, p21, and inhibition of topoisomerase activity. Here we have systematically studied the detailed cell death mechanism of this drug using three colon cancer cell lines (HCT-116 parental, isogenic HCT-116 p53-/-, and HCT-116 p21-/- sublin

Resuspension of road dust contributes to air quality issues with resulting health impacts. Limited studies imply that porous pavements can initially mitigate PM10 emissions by acting as a dust trap, but the abrasion wear generates road dust and thus accelerates the clogging processes. In addition, knowledge regarding the impact of pavement types on road dust load dynamics is limited. Road traffic

Objective: To describe the SHIELD cohort in terms of symptoms indicative of early knee osteoarthritis (OA) and to investigate associations between patient characteristics (demographics, activity/injury-related) and these symptoms at 1 (cross-sectional) and 3 years (longitudinal) post anterior cruciate ligament reconstruction (ACLR). Method: 106 participants (50 ​% women, mean [SD] age 25 [5] years

Several problems concern about energy are frequently discussed in recent decades, such as the shortage of traditional energy resource, the increase of energy price and the destruction of living environment by energy conversion. To solve these problems, sustainable development of energy become a preferential task all around the world. Under current circumstances, applying energy saving measures and

The development and consumption of functional food are increasing. To meet such an increasing demand, vegetable milk extracted from quinoa and fermented with lactic acid bacteria can offer an excellent alternative to fermented dairy milk which has a high nutritive value and is free from lactose, gluten and cholesterol. This research aims at: (a) isolating and identifying the autochthonous microbio

The aim of this master thesis is to investigate how the public libraries in the city of Malmö in Sweden, work with and towards babies under the age of one and their parents, with a specific focus on multilingual families. We also aim to investigate the awareness amongst the librarians in their meeting with this group. For this we use critical theory and an intersectional perspective using mainly t

Jorden tar emot ett konstant flöde av energi via solinstrålning som sedan cirkulerar mellan atmosfären, haven och markytan innan den slutligen strålas ut i rymden. Dessa energiflöden är bränslet som driver planetens väder- och klimatfenomen och det vetenskapliga samfundet efterfrågar ökad kunskap om detta system för att utmaningarna med klimatförändringar ska kunna förutspås och hanteras. En grundFlows of energy between the atmosphere, the oceans and the land surfaces drive weather and climate on Earth. Increased understanding of these processes is crucial to successfully predict and address the challenges of climate change. Land surface models (LSM) are mathematical models designed to mimic natural processes and evolution of land surfaces with the basic task to simulate surface-atmosphere

Since the rise of the tourism industry in Barbados in the 1960s a vast emphasis has been placed on expanding high dollar luxury tourism that is targeted towards specific social and economic classes in order to maintain foreign exchange. The majority of this high dollar tourism development has been predominately concentrated on the diminishing western coastlines of Barbados. Moreover, the focus on

The master’s thesis was performed in collaboration with the department responsible for the driver vehicle interaction at Scania CV AB. The interaction between the driver and the vehicle contributes to the usability and overall experience of the product as well as to safety. In order to create a good interaction it is important to evaluate it. The purpose of the thesis work was therefore to develop

Genom att utvärdera Skochparametern och skapa tre konceptkompressorer har examensarbetet försökt komma till en slutsats om hur bladens längdförhållande påverkar en kompressors verkningsgrad och stabilitet. Skochparametern visade sig fungera mindre bra som ett verktyg och det visade sig att ett lägre längdförhållande innebar en liten minsking i verkningsgrad, men en betydande ökning i stabilitet. The design of an axial compressor is mainly the trade-off between efficiency, stability and cost. A parameter that affects all of these three aspects is the blade aspect ratio. Due to the intricacy and complexity of the flow in a compressor, solely the effect of the blade aspect ratio variation is difficult to obtain. A parameter that supposedly is a gauge of the combined airfoil and end wall loa

Hur har föroreningar förändrats över tiden i nordligaste delen av Sverige? Om höga halter tungmetaller finns, vilka kan vara orsakerna till dessa? En resa från södra Skåne till norra Lappland har visat att de flesta metaller i sedimentet från en sjö har minskat på senare år, Hg samt Arsenik har dock ökat. Detta beror troligtvis på minskad användning av fossila bränslen samt gruvdriften i norr.Changes in the accumulation of heavy metals (Cd, Cu, Hg, Fe, Mn, Ni, Pb, Zn), arsenic (As), and selenium (Se) in sediment of pristine lake in northern Sweden were studied by making measurements at different depths in a sediment core. The sediment core was extracted from the deepest part of the lake Sautusjärvi, close to the village Jukkasjärvi. The sediment samples were transported in a cooler to

There is an increasing demand for safe, affordable and above allsustainable energy, due to the exhaustion of fossil fuels and increasing greenhousegas emissions. In this context, anaerobic digestion is of growing interest, as it enablesthe production of the versatile renewable energy source biogas from various types oforganic wastes. Though, in order to establish more efficient process policies, a

Homosexuella har i Sverige genom historien ständigt varit utsatta och diskriminerade. Homosexuella handlingar var kriminaliserade från 1608 till 1944 med undantag för införandet av 1734 års lag då den uttryckliga kriminaliseringen togs bort. Sedermera infördes kriminaliseringen åter i 1864 års strafflag. 1944 ersattes kriminaliseringen med en sjukdomsklassificering som varade till 1979. Under andThis paper examines the legislation that concerns the historical development of homosexuals’ rights in Sweden, with emphasis on the debate that led to the gender neutral definition of marriage. Homosexuals have, throughout the history, been exposed to discrimination in various ways. From 1608 until 1734 homosexual acts were outlawed, to be criminalized again in the Criminal law from 1864. In 1944

All words in Swedish have a particular melody. There are two tonal patterns that are observed in different prosodic and morphological contexts – accent 1 and accent 2. The tone of accent 1 is the default melody in Swedish and is said to be of intonational nature. The melody of accent 2, on the other hand, only occurs in presence of certain suffixes in the word, hence, accent 2 is claimed to be a p

Popular science summary Has climate change influenced flowering time of coltsfoot? Phenological events such as the onset of flowering during the spring are among the most sensitive indicators of climate change. Hence, phenological data have recently emerged as effective tools for studying the impact of climate change on species and ecosystems. In this study, I used records from herbaria and pub

Populärvetenskaplig sammanfattning: Drick ett glas goda bakterier Man har länge vetat att det i distributionsnät av dricksvatten växer bakterier i form av biofilm. Denna biofilm kan stabilisera vattenkvaliteten men kan också vara orsaken till vissa hälsoproblem eftersom den kan innehålla patogener, virus och protozoer. Djupare förståelse om hur biofilmer är uppbyggda och fungerar är också av intAbstract In water distribution systems newly exposed areas, such as newly laid pipes are subjugated to biofilm growth. This growth have been associated with public health problems and has lead to the water treatment facilities seen today. In an attempt to better understand what mechanisms are important when it comes to drinking water, research involving simulated distribution systems is being use

Populariteten för släktforskning har vuxit under dom senaste åren. Detta beror framför allt på att det blivit avsevärt enklare genom internets framfart. Idag kan privat personer bedriva släktforskning hemifrån då man tidigare behövde hjälp från arkivister och professionella släktforskare. Då stora mängder släktdata har digitaliserats och lagts ut på nätet genom olika internationella företag och idAssociation for computer aided genealogy research of Sweden(DIS) is investigating the possibility of a nationwide genealogical database (RGD) of Sweden's historical population. The finished database should contain basic information about individuals' names, birth, marriage, death, and individuals' relationships such as father, mother, husband/wife and children. This will make up a kind

This thesis aimed to develop and create a tool for 3D-artists at Sony Mobile Communications to improve and simplify the work when rendering new materials for their new products. The tool consists of a new product that would capture images for a panorama, where the images would contain a lot of light information, resulting in high dynamic range (HDR) files. This would be done by using the camera of

Populärvetenskaplig sammanfattning: De skånska bokskogarna. Vad kan krypen säga? Det är mycket som påverkar våra skogar i dag. Vägar som delar upp dem i mindre delar och lantbruk och kvävenedfall som stör balansen för vad som ska växa i skogens utkanter med sin gödsling. Även trafiken påverkar genom att kväveoxiderna i avgaserna har en gödande effekt. Skogens hälsa påverkas självklart av detta, Abstract Deforestation, fragmentation and loss of biodiversity, all are elements that are common today. With this project I want to evaluate if there is a difference in functional diversity of evertebrates between beech stands of low herb and shrub type beech forest. I also want to test if there is a difference within tested areas between low herb and shrub type forests, but also if here is a dif

Understanding how learning occurs, and what improves or impedes the learning process is of importance to academicians and practitioners; however, empirical research on validating learning curves is sparse. This paper contributes to this line of research by collecting and analyzing CAD (computer-aided design) procedural and cognitive performance data for novice trainees during 16-weeks of training.