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BACKGROUND: The in vivo clinical significance of malignant stem cells remains unclear. METHODS: Patients who have the 5q deletion (del[5q]) myelodysplastic syndrome (interstitial deletions involving the long arm of chromosome 5) have complete clinical and cytogenetic remissions in response to lenalidomide treatment, but they often have relapse. To determine whether the persistence of rare but dist
Aim: The present investigation was designed to evaluate the health-related quality of life (HRQOL) of adolescents with asthma between the age of 16 and 21, when they are transferred from paediatric to adult care. Methods: In this prospective study, 156 teenagers (69 females) with asthma were screened employing spirometry, a histamine challenge, skin prick test for allergy and filled out the 'Livin
A number of statistical techniques to analyze and model coastal morphological evolution over yearly and decadal (i.e., long-term) time scales based on field data are presented. After a general introduction to long-term morphological modeling, mainly linear methods are discussed, whereas nonlinear methods are treated in a companion paper (SOUTHGATE et al., 2001). The theoretical background to the m
Acute otitis media (AOM) is the most common reason for outpatient antimicrobial therapy. Mixed infections pose a potential problem, since the first-line drug used for the treatment of AOM, amoxicillin, can be neutralized by ß-lactamase-producing pathogens of the upper respiratory tract. To study the effects of a 5-day course of amoxicillin on a mixed middle ear infection, rats were challenged with
A monodispersive aerosol dynamic model, coupled to a 3D hydrodynamical grid model, has been used to study the dynamics of ultrafine particles inside a road tunnel in Stockholm, Sweden. The model results were compared to measured data of particle number concentrations, traffic intensity and tunnel ventilation rate. Coagulation and depositional losses to the tunnel walls were shown to be important p
We evaluated the feasibility and efficacy of using high-dose iodine-131-metaiodobenzylguanidine ((131)I-MIBG) followed by reduced-intensity conditioning (RIC) and transplantation of T cell-depleted haploidentical peripheral blood stem cells (designated haplo-SCT) to treat relapsing/refractory neuroblastoma (RRNB). Five RRNB patients were enrolled: 4 with relapse (3 after autologous SCT) and 1 with
Cigarette smoke exposure is a strong risk factor for cardiovascular and respiratory diseases. However, the knowledge about how cigarette smoke induces damage to vasculature and airway is limited. The present study was designed to examine the effects of cigarette smoke particles extracted by heptane (heptane-soluble smoke particles, HSP), by water (water-soluble smoke particles, WSP) and by DMSO (D
PURPOSE To improve the poor prognosis of patients with primary disseminated multifocal Ewing sarcomas (PDMES) with a dose-intense treatment concept. PATIENTS AND METHODS From 1999 to 2005, 281 patients with PDMES were enrolled onto the Euro-EWING 99 R3 study. Median age was 16.2 years (range, 0.4 to 49 years). Recommended treatment consisted of six cycles of vincristine, ifosfamide, doxorubicin, a
The complement system can be specifically targeted to tumor cells due to molecular changes on their surfaces that are recognized by complement directly or via naturally occurring antibodies. However, tumor cells often overexpress membrane-bound complement inhibitors protecting them from complement attack. We have previously shown that non-small cell lung cancer (NSCLC) cells, additionally to membr
PURPOSE: To study long term loco-regional and distant recurrence rate and survival after post-mastectomy radiotherapy in combination with oral cyclophosphamide in premenopausal women with stage II breast cancer. STUDY DESIGN: A three-armed randomized multicenter phase III trial comparing 1) Radiotherapy (RT) 2) RT+ oral cyclophosphamide for one year (RT+C) and 3) Oral cyclophosphamide only (C). Ra
OBJECTIVE: Regular blood pressure control has been advocated for early detection and treatment of patients with hypertension. We aimed to study whether long-term survival rate is related to socioeconomic circumstances and biological factors among middle-aged men with screened new hypertension. METHODS: Of the 22 444 men who attended a general health examination in Malmo, Sweden during 1974-1984, i
ABSTRACT: BACKGROUND: Long term endurance training is known to increase peak oxygen uptake () and induce morphological changes of the heart such as increased left ventricular mass (LVM). However, the relationship between and the total heart volume (THV), considering both the left and right ventricular dimensions in both males and females, is not completely described. Therefore, the aim of this stu
Pulmonary fibrosis is a hallmark of several systemic diseases such as systemic sclerosis. Initiation and early development is not well characterized, as initiation usually is unnoticed in patients, yet fibrosis has been considered a late event, occurring after an inflammatory phase. By utilizing an animal model, the starting point can be defined and the initiation process and early development tho
PURPOSE: To characterize a deletion of chromosome 2q at the molecular level in a patient suffering from severe epilepsy resembling severe myoclonic epilepsy of infancy/Dravet's syndrome (SMEI/DS) and to correlate other cases harboring deletions in the same region to morphological and clinical data. METHODS: Array-based comparative genomic hybridization (array CGH) was performed on DNA from the pat
In order to elucidate the influence of nicotine smoking on bone mass in elderly women, bone mass was cross-sectionally assessed by dual energy X-ray absorptiometry (DXA) in total body, hip and lumbar spine, as well as with ultrasound of calcaneus and phalanges of the hand. Subjects were 1,042, 75-year old women, recruited on a population basis (Osteoporosis Prospective Risk Assessment (OPRA) study
Mid-infrared polarization spectroscopy (IRPS) was applied to detect HCl in flames. For the first time, sensitive and nonin trusive HCl detection with a manner of high spatial- and temporal-resolution in harsh reactive gas flow has been demonstrated in this work. In an atmospheric pressure premixed CH4/O-2/Ar flat flame, trace level HCl was prepared by seeding small amount chloroform through the Ar
Popular Abstract in Swedish Ordet polymer användes första gången av Berzelius år 1830 och kommer ursprungligen från grekiskans polymeres, vilket betyder av flera delar ("poly"=flera och "meros"=del). En polymer är en lång molekyl gjord av flera upprepande enheter. Polymerer finns i naturen (t. ex. DNA och proteiner) men kan också tillverkas genom syntetiska processer. Om polymeren innehåller laddaThe work in this thesis concerns polymer gels, especially their swelling and mechanical properties modelled using a coarse-grained model of polyelectrolytes. The method used to study polymer gels was molecular simulation utilising the simulation package MOLSIM. Particular focus is on the effect of salt, macroions and network topology effects (polydispersity, loose-ends and interpenetrating network
Popular Abstract in Swedish Polyklorerade bifenyler (PCB) är ett samlingsnamn för ett antal kemiska föreningar. De utmärker sig genom att de har en god elektrisk isoleringsförmåga och tålighet för höga temperaturer, och de har därför använts i bl.a. transformatorer och kondensatorer men även som mjukgörare i plaster och färger. Sedan det visat sig att exponering för PCB innebar allvarliga hälsoeffPersistent organochlorine compounds (POC), such as polychlorinated biphenyls (PCB) and dioxins, are long-lived and highly lipophilic compounds which are present in all biota today. In Sweden, one of the major exposure routes for POC is through the consumption of fatty fish from the Baltic Sea, which is off the east coast of Sweden, and one of the most highly exposed populations is the fishermen's
Popular Abstract in Swedish Nervrotskompression i nacken - effekter av kirurgi, sjukgymnastik och halskrage. Under de senaste decennierna har besvär från halsrygg och axlar ökat hos befolkningen, medan besvär från ländrygg minskat. En orsak kan vara att tunga lyft i arbetet har minskat, medan sittande arbete med upprepade monotona armrörelser och arbete med framåtböjd nacke t.ex. framför datorskäThe efficacy of surgery, physiotherapy or a cervical collar in the treatment of chronic cervicobrachial pain of radicular origin was evaluated in a prospective, randomised study comprising 81 patients of both sexes, 28-64 years of age, referred for possible neurosurgical treatment. After neurological and radiological examination and giving their informed consent, they were randomised to one of the
The main function of CAs (carbonic anhydrases) is to participate in the regulation of acid-base balance. Although 12 active isoenzymes of this family had already been described, analyses of genomic databases suggested that there still exists another isoenzyme, CA XV. Sequence analyses were performed to identify those species that are likely to have an active form of this enzyme. Eight species had
