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The sensation of dryness and irritation is essential in the sick building syndrome (SBS), and such symptoms are common in both office and hospital employees. In Scandinavia, the indoor relative humidity in well ventilated buildings is usually in the range 10-35% in winter. The aim of this study was to evaluate the effect of steam air humidification on SBS and perceived air quality during the heati

Popular Abstract in Swedish Osteoporos (benskörhet) är en sjukdom som drabbar de äldre och leder till att skelettet urkalkas och därmed förlorar delar av sin styrka. Detta bidrager till olika typer av frakturer (brott av benet) där de vanligaste är handleds-, axel-, kot- och höftfrakturer. Andelen frakturer ökar i befolkningen, vilket både medför ökade kostnader för samhället och invaliditet för dThe aim of this thesis was to evaluate bone mass and bone size in girls and boys from age 12 to 16, with special attention to physical activity. We also wanted to retrospectively evaluate the effect of exercise for the years preceding age 12. The findings were as follows. Sixteen year old adolescents in a rural area had higher areal bone mineral density in the total body and the spine compared wit

This thesis is based on three projects that deal with vertical III-V semiconductor devices. The work spans over basic research as well as more applied aspects of III-V semiconductor technology. All projects have in common that they rely on advanced epitaxial growth to form the starting material for device fabrication.In chapter two, zero-dimensional Quantum Dots (QDs) are incorporated into electro

Importance: Proposal of an innovative approach to clarify the mechanism through which poor cognitive performance in adolescence impacts risk for schizophrenia (SZ).Objective: To determine whether the developmental processes that predispose to SZ are better reflected by the observed cognitive performance in adolescence or the deviation of that performance from the individual's familial cognitive ap

BACKGROUND: A possible role for prostate cancer in Lynch syndrome has been debated based on observations of mismatch-repair defective tumors and reports of an increased risk of prostate cancer in mutation carriers. Potential inclusion of prostate cancer in the Lynch syndrome tumor spectrum is relevant for family classification, risk estimates and surveillance recommendations in mutation carriers.M

The humoral immune response to human cytomegalovirus (CMV) membrane glycoprotein gp58/116 (gB) has been studied by establishing cell lines producing specific human monoclonal antibodies. These cell lines were generated from peripheral blood lymphocytes obtained from a healthy carrier. Hybridomas producing gp58/116-speciftc antibodies were detected by reactivity to procaryotically expressed protein

Background: Uncertainty is inevitable in clinical practice in primary care and tolerance for uncertainty and concern for bad outcomes has been shown to vary between physicians. Uncertainty is a factor for inappropriate antibiotic prescribing. Evidence-based guidelines as well as near-patient tests are suggested tools to decrease uncertainty in the management of patients with respiratory tract infe

A new technique for two-dimensional temperature measurements of burning surfaces is presented. Laser-induced phosphorescence from a thermographic phosphor material applied to a surface of investigation was measured with a fast framing camera. The phosphor was excited by the 4th harmomic from a pulsed Nd:YAG operating at 10 Hz. The phosphorescence images measured by eight consecutively gated CCD de

BACKGROUND: The common ABO allele sequences are known, but little or no genetic information is available on the rare but important A subgroups. STUDY DESIGN AND METHODS: Blood group ABO polymorphism was analyzed in genomic DNA from 45 rare subgroup A individuals by sequence-specific primer polymerase chain reaction and amplified fragment length polymorphism investigating exons VI and VII in the AB

Popular Abstract in Swedish I denna avhandling studeras den akuta inflammatoriska reaktionen i huden. Akut inflammation beskrevs redan under romersk tid av Aulus Cornelius Celsus. Han karakteriserade denna reaktion med rodnad, svullnad, värme och smärta. Fysiologiskt består akut inflammation av vidgning av små blodkärl (vasodilatation) som ger upphov till rodnad samt av läckage av plasmaproteiner This thesis examines the microvascular inflammatory response in the skin. The microvascular response includes vasodilatation and plasma exudation. In the first three studies, the combined response was measured in guinea pig skin with a technique based on detection of radiolabelled protein. Transferrin was labelled in vivo by injection of 113mIn and the conversion electrons detected over the skin u

Objective: To monitor changes in serum concentrations of cartilage oligomeric matrix protein (COMP) during a 24-h period to determine any diurnal variation, and to estimate the half life of COMP in the circulation in patients with symptomatic knee osteoarthritis and in those with rheumatoid arthritis. Methods: Serum samples were drawn every 4 h (7 samples/patient over 24 h) in 10 patients with kne

OBJECTIVES. To compare family physicians' reported practice habits on hypertension in Sweden and Minnesota, and to assess to what extent different national guidelines account for differences. DESIGN. Random samples of family physicians were selected for telephone interviews on their practice of hypertension. SETTING. Primary care in southern Sweden and in Minnesota. SUBJECTS. Family medicine speci

Forestry in Sweden suffers from browsing damage caused by large herbivores, mainly moose (Alces alces) and roe deer (Capreolus capreolus). Silviculture affects the availability of forage for these animals, and thus the browsing pressure. A step towards modeling the response of trees or to predict browsing damage is to gain more knowledge on the availability of food in forest stands. Individual gap

The antithrombotic effect of bovine activated protein C (bAPC) given with or without bovine protein S (bPS) was investigated in a rat model of deep arterial injury. A segment of the left common carotid artery was isolated between vascular clamps and opened longitudinally. An endarterectomy was performed and the arteriotomy was closed with a running suture, whereafter the vessel was reperfused by r

Background: Funding organisations and research ethics committees (RECs) should play a part in strengthening attention to gender equality in clinical research. In the research policy of European Union (EU), funding measures have been taken to realise this, but such measures are lacking in the EU policy regarding RECs. Objective: To explore how RECs in Austria, Germany, Ireland, The Netherlands and

In balance clinic practice, phobic postural vertigo is a term used to define a population with dizziness and avoidance behavior often as a consequence of a vestibular disorder. It has been described as the most common form of dizziness in middle aged patients in dizziness units. Anxiety disorders are common among patients with vestibular disorders. Cognitive-behavioral therapy is an effective trea

Purpose: The beneficial effects of antimuscarinics on detrusor overactivity and overactive bladder syndrome are exerted during bladder filling, when there is no parasympathetic outflow from the spinal cord. We tested the hypothesis that, if tolterodine exerts some of its effects on afferent nerves, the functional elimination of C-fiber afferents should affect the actions of the drug on urodynamic

The X-linked form of Alport syndrome (AS) is caused by mutation in the COL4A5 gene located at Xq22.3 and encoding the alpha 5-chain of type IV-collagen. More than 400 different mutations have so far been detected in the COL4A5 gene. Not all mutations, however, will be detected using an exon-by-exon mutation detection strategy such as SSCP analysis or direct sequencing. We have previously reported

Background & Aims: The COMET trial was a prospective, double-blind, randomised trial comparing carvedilol, a comprehensive adrenergic receptor antagonist, with metoprolol, a beta-1-selective agent in patients with heart failure and left ventricular systolic dysfunction. The trial showed a reduction in mortality with carvedilol that was consistent across subgroups. The purpose of this report is

This report describes technical improvements to the manufacture of a carbon fibre electrode for the stable and sensitive detection of H2O2 (detection limit at 0.5 mu M). This electrode was also modified through the co-immobilisation of acetylcholinesterase (AChE) and/or choline oxidase (ChOx) in a bovine serum albumin (BSA) membrane for the development of a sensor for in vivo measurements of acety