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Acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS) limit the utilization of donor lungs for transplantation but is also a common cause of death in the intensive care unit. There is a general lack of diagnostic tools by which to assess lung function in ARDS but, in addition, the treatments offered are limited. In the present thesis, the aim was to explored

Background: Approximately 40% of cancer patients/survivors develop chronic cancer-related pain (CRP), which is often associated with greater levels of fatigue and cancer worry, all of which are associated with poorer functioning, wellbeing, and greater healthcare costs. Psychological Flexibility (PF) refers to one’s level of openness to and acceptance of physical/emotional experiences and willingn

Abstract: For patients with locally advanced head and neck tumours or other defects, the preferred curative treatment is extensive reconstructive surgery using free microvascular flap(s), oftentimes followed by postoperative radiotherapy. The procedure offers superior functional and aesthetic advantages, but the treatment course is long and complex and burdened with a significant risk of complicat

Bryophytes constitute a diverse plant group with important roles in ecosystem functioning, in particular in arctic and subarctic environments. As they are physiologically strongly dependent on climatic conditions bryophytes could serve as indicators of ongoing climatic change. Their spores are generally dispersed by wind, and because of contrasting phenologies among species, the composition of the

Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. Objective: To examine the association between depressive symptoms and amyloid pathology and its dependency on age,

Background and Aims. While the rationale for coronavirus disease 2019 (COVID-19) vaccination is to reduce complications and overall mortality, some cardiovascular complications from the vaccine itself have been demonstrated. Myocarditis and pericarditis are recognized as rare acute adverse events after mRNA vaccines in young males, while evidence regarding other cardiovascular events remains limit

Background and purpose: Hormone-receptor-positive/HER2-negative (HR+/HER2-) early-stage breast cancers (EBCs) display heterogenous responses to neoadjuvant chemotherapy (NACT) warranting biomarkers to tailor optimal treatment for individual patients. Patients/material and methods: Women with HR+/HER2-EBC (N = 178) included in the Swedish Sweden Cancerome Analysis Network-Breast (SCAN-B) population

Ectomycorrhizae is a mutualistic association between roots of woody plants and a diverse range of soil fungi. The fungi exchange soil derived mineral nutrients for photosynthetic sugars from the host plant. The mycorrhizal symbioses are commonly found in all forest ecosystems and have a major ecological and economical importance. I have used comparative genomics, DNA microarrays and computational

Popular Abstract in Swedish Avhandlingens syfte är att ge ett bidrag till att belysa hur olika teorier och modeller kan förklara den sociala, kulturella och psykologiska situation som en avgränsad grupp kvinnor med narkotikaproblem befinner sig i. I avhandlingen görs en ansats att integrera ett socialpsykologiskt perspektiv med ett kvinnoforskningsperspektiv och ett personlighetspsykologiskt perspThe purpose of this study was to systematically examine the social, cultural and psychological situation of a group of women with drug addiction, and to gain an understanding of it. Different theoretical perspectives were utilized in efforts to understand and explain why some young women start using drugs. The attempt was made to integrate a social psychological perspective with a perspective base

Popular Abstract in Swedish Många av dagens biotekniska processer syftar till att framställa protein. Det är proteinets användningsområde som är avgörande för vilka renhetskrav som ställs på produkten. I vissa fall måste proteinet vara helt fritt från föroreningar för att inte åstadkomma oönskade effekter. Vaccinframställning är ett exempel på en sådan tillämpning. För andra ändamål, t ex vid framTwo polymers, alginate and Eudragit S-100 were used as reversibly soluble-insoluble ligand carriers for the selective isolation of enzymes and lectins respectively. These two polymers have the inherent property of being precipitated under well defined conditions. Alginate was made insoluble by the addition of Ca2+ ions, and Eudragit S-100 by a pH shift. The polymers were modified with affinity lig

Steady state and time-resolved absorption and fluorescence spectroscopy have been used to investigated the energy transfer in photosynthetic purple bacteria. Picosecond light pulses were used in measurements of Rb. sphaeroides WT and a LH1-deleted mutant, demonstrating that the energy trapping into the reaction center in both species occur on the same time-scale, and that the excitation energy is

Popular Abstract in Swedish Migration (folkvandring) är idag en global företeelse. Orsaken till migrationen varierar och kan bero på krig och förföljelse, naturkatastrofer, familjeskäl, fattigdom, studier eller sökande efter arbete. I slutet av förra seklet var Sverige en nation där fattigdom och religiöst förtryck drev drygt en miljon människor över haven till Nordamerika och andra världsdelar. IAbstract Aims: To analyse the influence of migration status (country of birth/ethnicity), accultura-tion, socio-economic and psychosocial factors on self-reported psychiatric illness, suicide attempt, total mortality and violent death. Methods: Three main data sources were used: suicide attempts in the catchment area of Lund University Hospital (PASIS) during 1991–94; the Swedish Survey of Living

Aim Spatial evolutionary and ecological vicariance analysis (SEEVA) is a simple analytical method that evaluates environmental or ecological divergence associated with evolutionary splits. It integrates evolutionary hypotheses, phylogenetic data, and spatial, temporal, environmental and geographical information to elucidate patterns. Using a phylogeny of Prepusa Mart. and Senaea Taub. (Angiosperma

Background: Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke. Building on baseline MRI examinations from the centralized and structured radiological assessments of ischemic stroke patients in the Stroke Genetic

BACKGROUND: The diagnosis of chronic obstructive pulmonary disease is based on the presence of persistent respiratory symptoms and chronic airflow limitation (CAL). CAL is based on the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1:FVC) after bronchodilation, and FEV1:FVC less than the fifth percentile is often used as a cut-off for CAL. The aim was to investigate if incre

1. Neuropeptide Y (NPY) and peptide YY (PYY) act at receptors referred to as Y1 and Y2, while the Y3 receptor is specific to NPY and does not recognize PYY. The effects of NPY, its related peptides and a series of newly constructed chimeric NPY-PYY peptides were examined on excitatory and inhibitory postsynaptic currents (e.p.s.cs and i.p.s.cs, respectively) in rat dorsomedial nucleus tractus soli

Abstract: HLA‐DR2 is negatively associated with insulin‐dependent diabetes mellitus (IDDM). The aim of the present study was to analyze DR2‐positive patients among 425 consecutively diagnosed unrelated Swedish children with IDDM and in 367 matched controls. HLA‐DRB, ‐DQA and ‐DQB were determined by Taq I restriction fragment length polymorphism analysis. Amplification by polymerase chain reaction

Background: Guidelines for the emergency management of mild traumatic brain injury have been used for over a decade and are considered safe. However, they recommend computerized tomography for at least half of these patients. The Scandinavian Neurotrauma Committee guideline uses serum S100B protein level to rule out intracranial hemorrhage. Analysis of capillary serum S100B protein level has not y

UNLABELLED: The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.INTRODUCTION: Population studies of vitamin D receptor (VDR) polymorphisms have produced conflicting results. We p