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Cohort study of prediction of venous thromboembolism in emergency department patients with extremity symptoms

Despite diagnostic algorithms, identification of venous thromboembolism (VTE) in emergency departments (ED) remains a challenge. We evaluated symptoms, background, and laboratory data in 27,647 ED patients presenting with pain, swelling, or other symptoms from the extremities, and identified predictors of VTE diagnosis within one year. Predictors of a clinical decision to perform phlebography, ult

Right ventricular stroke work index from echocardiography in patients with pulmonary arterial hypertension-the role in short-term follow-up assessment

AimsRight ventricular (RV) failure causes high mortality in patients with pulmonary arterial hypertension (PAH). RV stroke work index (RVSWi) poses as a potential predictor of outcome. We evaluated how RVSWi by echocardiography (ECHO) or right heart catheterization (RHC) is altered following PAH treatment and if RVSWi is an indicator of outcome in PAH.Methods and resultsFifty-four patients with PA

Expression of Terpene Synthases from Edible Fungi using Yeast Chassis

Secondary metabolites produced from organisms are compounds that are not directly connected to the growth of organisms but that serve many important purposes for them in nature. Terpenes and terpenoids form a section of the secondary metabolites, produced from terpene synthase (TPS) enzymes. Fungal species are highly dependent on secondary metabolites and especially the terpenoid compounds for num

Turbo For Fuel Cell Electric Vehicle

Turbo systems have long been implemented into vehicles to increase the specific power. Increasing the pressure for conventional vehicles decreases the mass of the engine and increases the efficiency. Conventional vehicles do however produce carbon dioxide emissions which have become an increasing issue that needs a solution. One possible solution is the fuel cell utilizing hydrogen as fuel. This r

Control Strategies for Physical Human—Robot Collaboration

Recent industrial interest in producing smaller volumes of products in shorter time frames, in contrast to mass production in previous decades, motivated the introduction of human—robot collaboration (HRC) in industrial settings, to increase flexibility in manufacturing applications. As a consequence, industrial environments would lose their fixed structure, thus increasing the uncertainties prese

The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease

Background: Mutations in the PRSS1 gene explain most occurrences of hereditary pancreatitis (HP) but many HP families have no PRSS1 mutation. Recently, an association between the mutation N34S in the pancreatic secretary trypsin inhibitor (SPINK1 or PSTI) gene and idiopathic chronic pancreatitis (ICP) was reported. It is unclear whether the N34S mutation is a cause of pancreatitis per se, whether

Use of anti-asthmatic drugs during pregnancy. 1. Maternal characteristics, pregnancy and delivery complications.

Objective To study, in a large cohort, the association between the use of anti-asthmatic drugs during pregnancy and pregnancy complications. Methods Using the Swedish Medical Birth Register, we identified 24,369 women who reported the use of anti-asthmatic drugs in early pregnancy and 7778 women who were prescribed such drugs later during pregnancy by antenatal care system centres, during the peri

Protein partitioning in thermoseparating systems of a charged hydrophobically modified ethylene oxide polymer

The phase behavior of a thermoseparating cationic hydrophobically modified ethylene oxide polymer (HM-EO) containing tertiary amines has been investigated at different pH, salt and sodium dodecyl sulfate (SDS) concentrations, in order to find a water/HM-EO two-phase, system suitable for protein partitioning. The used polymer forms micellar aggregates that can be charged. By changing pH and SDS con

Xenoestrogenic activity in blood of European and Inuit populations

BACKGROUND: Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiph

Döva barns begreppsbildning i matematik

Popular Abstract in Swedish Döva barns begreppsbildning i matematik Denna studie tar utgångspunkt i frågan varför många döva barn har svårt att lära sig matematik. Studiens syfte är att belysa döva barns begreppsbildning i ämnet matematik genom att beskriva hur några döva barn uttrycker sig och agerar på väg mot förståelse av två centrala matematiska begrepp, nämligen multiplikation med heltal ochThe question why deaf children have difficulties in learning mathematics is the basis of this study. The aim of the study is to illuminate deaf children’s concept formation in mathematics by describing how some deaf children express themselves and act on their way towards understanding two basic concepts, the concept of multiplication with whole numbers and the concept of length. Theories develope

Occupational exposure to commercial decabromodiphenyl ether in workers manufacturing or handling flame-retarded rubber

Commercial decabromodiphenyl ether (DecaBDE) is commonly used as a flame retardant in different electrical and textile applications. It is also used in the production of flame-retarded rubber compound. DecaBDE is the major technical polybrominated diphenyl ether (PBDE) in use today and consists mainly of decabromodiphenyl ether(BDE209). PBDEs, including BDE-209, are well-known environmental pollut

The Diabetic Foot. Costs, health economic aspects, prevention and quality of life.

Popular Abstract in Swedish Diabetesfoten - Samhällsekonomiska kostnader, hälsoekonomiska aspekter, prevention och livskvalitet Orsak och förekomst. Fotsår är en relativt vanlig komplikation hos personer med diabetes. Ungefär 15% av alla vuxna diabetiker drabbas någon gång av fotsår. Orsakerna till att sår uppstår beror på en ökad risk för nervskador och kärlproblem hos diabetiker. Nervskadorna yThe overall aims were to investigate the economic consequences of foot complications in diabetic patients, to measure the influence of diabetic foot complications on health-related quality of life (HRQL), and to analyse the cost-effectiveness of interventions to prevent foot ulcers and lower extremity amputations (LEA). The economic consequences of foot ulcers and LEA are large both in a short an

Formation, pattern and physiological effects of short-chain fatty acids - Impact of various indigestible

The short-chain fatty acids (SCFA) formed from colonic fermentation of indigestible carbohydrates have been suggested to exert different physiological effects. In this thesis the fermentability and SCFA produced from various indigestible carbohydrates in the hind-gut were investigated using balance experiments in rats. In the case of propionate, experiments were also performed to evaluate possibl

Synthesis and Characterization of a Family of POCOP Pincer Complexes with Nickel: Reactivity Towards CO2 and Phenylacetylene.

A cyclohexyl-based POC sp 3OP pincer ligand (POC sp 3OP=cis-1,3-bis(di-tert-butylphosphinito)cyclohexyl) cyclometalates with nickel to generate a series of new POC sp 3OP-supported Ni(II) complexes, including the halide, hydride, methyl, and phenyl species. trans-[NiCl{cis-1,3-bis(di-tert-butylphosphinito)cyclohexane}], [(POC sp 3OP)NiCl] (1 a) and the analogous bromide complex (1 b) were synthesi

Annual changes in MODIS vegetation indices of Swedish coniferous forests in relation to snow dynamics and tree phenology

Remote sensing provides spatially and temporally continuous measures of forest reflectance, and vegetation indices calculated from satellite data can be useful for monitoring climate change impacts on forest tree phenology. Monitoring of evergreen coniferous forest is more difficult than monitoring of deciduous forest, as the new buds only account for a small proportion of the green biomass, and t

Gene expression under thermal stress varies across a geographic range expansion front.

Many ectothermic species are currently expanding their distributions polewards due to anthropogenic global warming. Molecular genetic mechanisms facilitating range expansion under these conditions are largely unknown, but understanding these could help mitigate expanding pests and disease vectors, or help explain why some species fail to track changing climates. Here, using RNA-seq data, we examin

Early-stage cervical cancer: Tumor delineation by magnetic resonance imaging and ultrasound - A European multicenter trial

Objective. To compare the diagnostic accuracy of ultrasound (US) and magnetic resonance imaging (MRI) in the preoperative assessment of early-stage cervical cancer using pathologic findings as the reference standard. Patients and methods. Prospective multi-center trial enrolling 209 consecutive women with early-stage cervical cancer (FIGO IA2-IIA) scheduled for surgery. The following parameters we

Increase of club cell (Clara) protein (CC16) in plasma and urine after exercise challenge in asthmatics and healthy controls, and correlations to exhaled breath temperature and exhaled nitric oxide.

Exercise is known to affect the airway epithelium through dehydration, followed by a release of mediators, such as club cell (Clara) protein (CC16). The aim of this study was to follow the CC16 levels at repeated time points in plasma and urine after exercise in asthmatic subjects and controls, and to relate the findings to exhaled breath temperature (EBT) and exhaled nitric oxide (NO). Twenty-two

Dietary Fat, Fat Subtypes and Hepatocellular Carcinoma in a Large European Cohort.

The role of amount and type of dietary fat consumption in the aetiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed

Association of transcript levels of 10 established or candidate-biomarker gene targets with cancerous versus non-cancerous prostate tissue from radical prostatectomy specimens

Objectives: The benefits of PSA (prostate specific antigen)-testing in prostate cancer remain controversial with a consequential need for validation of additional biomarkers. We used highly standardized reverse-transcription (RT)-PCR assays to compare transcript levels of 10 candidate cancer marker genes - BMP6, FGF-8b, KLK2, KLK3, KLK4, KLK15, MSMB, PCA3, PSCA and Trpm8 - in carefully ascertained