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PURPOSE. To analyze retinal structure and function in vitelliform macular dystrophy (VMD) due to mutations in BEST1. METHODS. Patients from five Swedish and four Danish families were examined with electrooculography (EOG), full-field electroretinography (ffERG), multifocal ERG (mfERG), optical coherence tomography (OCT), and fundus autofluorescence photography (FAF). Genetic analysis of the BEST1

Nitrogen leaching from boreal and temporal forests, where normally most of the nitrogen is retained, has the potential to increase acidification of soil and water and eutrophication of the Baltic Sea. In parts of Sweden, where the nitrogen deposition has been intermediate to high during recent decades, there are indications that the soils are close to nitrogen saturation. In this study, four diffe

Multiexciton absorption cross sections are important for analysis of a number of experiments, including multiple exciton generation and stimulated emisson. We present a rigorous method to determine these cross sections using transient absorption (TA) measurements. We apply the method to CdSe quantum dots (QDs) and core–shell (CdSe)ZnS QDs. The method involves measuring TA dynamics for various exci

We present experimental measurements of the vibrational relaxation of CO2 (12(0)1) by argon, at ambient temperature (295 +/- 2 K). The CO2 molecules were directly excited to the (12(0)1, J = 14) ro-vibrational state by a tunable laser radiation at similar to 2 mu m. Time-resolved infrared fluorescence technique was used to study the collisional relaxation process. The bimolecular deactivation rate

Popular Abstract in Swedish Diarré är ett vanligt symptom i befolkningen och det finns många differentialdiagnoser bakom orsaken till detta. En är inflammatorisk tarmsjukdom, något som har ökat kraftigt de senaste decennierna. Idag beräknar man att ca 1% av befolkningen har någon form av inflammatorisk tarmsjukdom och den klassas därför som en folksjukdom i Sverige. De inflammatoriska tarmsjukdomCollagenous colitis (CC) affects middle-aged women and results in chronic watery non-bloody diarrhoea. The incidence of CC has increased but has never been determined in southern Sweden. During the period 2001-2010 the mean annual incidence was stable; 5.4/105 (median age 71 years). The female: male ratio was 2.8:1, lower than in previous reports. The association between smoking and classic IBD is

The Price of Democracy and the Value of Literature : Books, Politics, and the Literary Market with Respect to the 2002 Reduction in VAT on Books in Sweden In 2002 the VAT (value added tax) on books in Sweden was reduced from 25% to 6 %. The reduction was effected in response to a cultural policy, whose aim was to ”improve the conditions for literature and reading” and ”stimulate a diversifed out

The aim of this study was to explore community perceptions about child sexual abuse in Tanzania. Thirteen focus group discussions were conducted with adult community members. The core category, children's rights challenged by lack of agency, was supported by eight categories. Aware but distressed portrayed feelings of hopelessness, lack of trust in the healthcare and legal systems reflected percei

MRI diffusion tensor imaging (DTI) studies of white matter integrity in behavioral variant frontotemporal dementia have consistently shown involvement of frontal and temporal white matter, corresponding to regional loss of cortical volume. Volumetric imaging has a suboptimal sensitivity as a diagnostic tool and thus we wanted to explore if DTI is a better method to discriminate patients and contro

A characteristic feature of non-muscle-invasive bladder cancer (NMIBC) is the high risk of recurrent disease after primary treatment. Although only a minority of cases eventually progress to a life-threatening muscle-invasive tumour, it is necessary to conduct long-term follow-up with repeated cystoscopies. In addition to the negative mental and physical impact that this has on the patient, the ex

Aim and objectives. This article explores relatives' experiences of receiving soft tissue massage as a support supplement while caring for a dying family member at home. Background. In palliative home care, relatives play an important role as carers to seriously ill and dying family members. To improve their quality of life, different support strategies are of importance. Complementary methods, su

Ankylosing Spondylitis (AS) is a chronic, potentially disabling, inflammatory disease that poses a longstanding burden on the patient and the society. The epidemiology of AS in Sweden has not been extensively studied previously. Radiographic and self-perceived health information from 1,005 men aged 69-81 years, showed a prevalence of moderate to severe radiographic sacroiliitis of 1.4% (95% Confid

Weld residual stress (RS) measurements are often undertaken on test-pieces which have been Cut Out from large components, yet it remains unclear to what extent the RSs in test-pieces are representative of those present in the original component. Similarly weld mechanical performance tests are frequently undertaken on cross-weld test-pieces without a proper understanding of the level or influence o

Most patients with acute myeloid leukemia (AML) are older, the median age is 71 years, and survival decreases rapidly with age. The achievement of complete remission and long-term survival mostly require intensive combination chemotherapy, but standard regimens are often believed to be too toxic for older patients. The Swedish Acute Leukemia Registry is unique and contains data on 98% of all patie

POU5F1 has two alternatively spliced transcripts: a long (variant 1, NM_002701) and a short (variant 2, NM_203289) transcript. Only variant 1 is a key regulator of pluripotency. Hence, it is important to be able to distinguish this transcript from variant 2 and from the many pseudogenes present in the genome. Previous studies on the expression of POU5F1 were, however, usually carried out without c

Fifteen primary liver carcinomas (PLCs), including 12 hepatocellular carcinomas and three cholangiocellular carcinomas, were investigated cytogenetically after short-term culture. Ten tumors displayed clonal chromosomal abnormalities, whereas only normal karyotypes were detected in four cases, and one sample failed to grow in vitro. Structural rearrangements most often involved chromosomes 1, 7, a

The objective of the study was to measure the lactate dehydrogenase (LD) activity in vaginal lavage fluid of women with vaginitis/vaginosis and in healthy pre- and post-menopausal controls. Also to analyse the LD isoenzyme patterns in such samples and compare the influence on the LD activity by different storage and sampling methods. Twenty of the women studied, who had no signs of inflammation as

Syftet med denna undersökning var att bestämma en 1 kg isvästs kylverkan på kroppen vid brandmansarbete. Testerna genomfördes i en klimatkammare, i en container med extrem strålningsvärme och i ett rökdykningshus med värme och tungt arbete. Den faktiska kylverkan mättes också med en termisk docka. Fyra erfarna brandmän deltog i försöken. I alla tester bar försökspersonerna standardklädsel för branThe aim of the present study was to examine the effects of wearing a light-weight ice-vest (1kg, water) on physiological and subjective responses in fire fighter’s work. The experiments were carried out in a climatic chamber, in a container under extreme radiant heat, and during simulated smoke-diving. In addition, the physical cooling effect of the ice-vest was measured with a thermal mannequin.

Popular Abstract in Swedish Organiska miljögifter finns idag i hela världen och har spridits dels genom lokala utsläpp och dels genom atmosfärisk transport. Trots att flera miljögifter (som insektsmedlet DDT och industrikemikalien PCB) har varit förbjudna sedan början av 1970-talet ser vi fortfarande höga halter av miljögifter i vår natur. Dels beror detta på att organiska miljögifter är svårnedbrAtlantic salmon (Salmo salar) from the Baltic Sea suffer from a reproduction disease known as the M74-syndrome. Newly hatched fry develop nerve disorders and die between 3-5 days after the first symptoms are seen. This is a maternally transmitted disease that is casued by a thiamine (vitamin B1) deficiency. The factor(s) that casue(s) this thiamine deficiency are largely unknown. However, several

Extrapair fertilizations (EPFs) have been found in most socially monogamous passerine species. EPFs are generally beneficial for males because they increase the number of sired offspring. The benefit accrued by females, however, is less obvious. Maternal benefits may involve fertility insurance, increased genetic variability of the offspring, and improved offspring quality via compatible genes or

Background & Aims: The importance of genetic factors for the development of primary sclerosing cholangitis (PSC) is incompletely understood. This study assessed the risk of PSC and inflammatory bowel disease (IBD) among first-degree relatives of patients with PSC, compared with the first-degree relatives of a cohort without PSC. Methods: Subjects from the national Swedish cohort of PSC patient