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Variable proportions of phylogenetic clustering and low levels of antiviral drug resistance among the major hbv sub-genotypes in the middle east and North Africa

Hepatitis B virus (HBV) infection remains a major public health threat in the Middle East and North Africa (MENA). Phylogenetic analysis of HBV can be helpful to study the putative transmission links and patterns of inter-country spread of the virus. The objectives of the current study were to analyze the HBV genotype/sub-genotype (SGT) distribution, reverse transcriptase (RT), and surface (S) gen

Raising Voices : Singing repertoire and practices in Swedish schools

This doctoral study aims to (i) investigate current song repertoire and singing practices in Swedish elementary school music education and (ii) to critically assess what factors may be seen to affect singing practices and repertoire choice. It looks to map out how much young students are singing in the general music classroom, what they sing, and how they sing, and to discuss possible implications

Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAX®, Falls, and BMD in the Osteoporotic Fractures in Men (MrOS) Study : A Meta-Analysis

Dual-energy X-ray absorptiometry (DXA)-derived appendicular lean mass/height2 (ALM/ht2) is the most commonly used estimate of muscle mass in the assessment of sarcopenia, but its predictive value for fracture is substantially attenuated by femoral neck (fn) bone mineral density (BMD). We investigated predictive value of 11 sarcopenia definitions for incident fracture, independent of fnBMD, fractur

Is the Nagoya Protocol designed to conserve biodiversity?

We have entered a monumental era in terms of realizing the impact of biodiversity loss on our everyday lives. We suffer from the consequences of biodiversity loss due to overexploitation of natural resources as we continue failing to restore biodiversity. One of the major consequences of biodiversity loss is the emergence of global pandemics. We are in urgent need of realizing the full potential o

Diet and bowel function in children with Hirschsprung’s disease : development and content validation of a patient-reported questionnaire

Background: Although dietary adjustments are recommended frequently for bowel symptoms, evidence of diet’s impact on bowel function is lacking. The aim was to develop a patient-reported outcome instrument, for children with and without Hirschsprung’s disease (HD), to explore experiences of dietary effects on bowel function. Methods: Children with and without HD and their parents participated. Ques

Coronary artery calcification and aortic valve calcification in patients with kidney failure : a sex-disaggregated study

Background: Chronic kidney disease (CKD) is linked to an increased cardiovascular disease (CVD) burden. Albeit underappreciated, sex differences are evident in CKD with females being more prone to CKD development, but males progressing more rapidly to kidney failure (KF). Cardiovascular remodelling is a hallmark of CKD with increased arterial and valvular calcification contributing to CKD. However

The perspective of children on factors influencing their participation in perioperative care

Aims and objectives: To describe the experiences of participation in perioperative care of 8- to 11-year-old children. Background: All children have the right to participate in decisions that affect them and have the right to express their views in all matters that concern them. Allowing children to be involved in their perioperative care can make a major difference in terms of their well-being by

Pacemaker implantation following tricuspid valve annuloplasty: A SWEDEHEART study

ObjectiveTricuspid annuloplasty is associated with increased risk of atrioventricular block and subsequent implantation of a permanent pacemaker. However, the exact incidence of permanent pacemaker, associated risk factors, and outcomes in this frame remain debated. The aim of the study was to report permanent pacemaker incidence, risk factors, and outcomes after tricuspid annuloplasty from nation

Neighborhood deprivation in relation to lung cancer in individuals with type 2 diabetes—A nationwide cohort study (2005–2018)

Background Neighborhood deprivation has been found associated with both type 2 diabetes and lung cancer. The aim of this study was to examine the potential association between neighborhood deprivation and lung cancer incidence or mortality in individuals diagnosed with type 2 diabetes. The results may identify a new risk or prognostic factor for lung cancer in this important subgroup and help deve

Survival in Swedish patients with systemic sclerosis : A nationwide population-based matched cohort study

Objectives: To conduct the first-ever nationwide, population-based cohort study investigating survival patterns of all patients with incident SSc in Sweden compared with matched individuals from the Swedish general population. Methods: We used the National Patient Register to identify patients with incident SSc diagnosed between 2004 and 2015 and the Total Population Register to identify comparato

Markers of Atrial Myopathy in the General Population : Prevalence, Predictors, and Inter-Relations

BACKGROUND: Atrial myopathy refers to structural and functional cardiac abnormalities associated with atrial fibrillation and stroke, but appropriate diagnostic criteria are lacking.OBJECTIVES: This study aimed to assess prevalence, clinical correlates, and overlap between potential atrial myopathy markers.METHODS: The population-based SCAPIS (Swedish CArdioPulmonary bioImage Study) prospectively

Diabetes risk during pregnancy among second-generation immigrants : A national cohort study in Sweden

Background and aims: Gestational diabetes is more common in many first-generation immigrant women in Europe and other Western countries. Less is known about second-generation immigrant women; such knowledge is needed to understand generational influences on diabetes risk. We aimed to study second-generation immigrant women regarding the presence of all types of diabetes during pregnancy. Methods a

The effect of statin treatment on intratumoral cholesterol levels and LDL receptor expression : a window-of-opportunity breast cancer trial

BACKGROUND: Deregulated lipid metabolism is common in cancer cells and the mevalonate pathway, which synthesizes cholesterol, is central in lipid metabolism. This study aimed to assess statin-induced changes of the intratumoral levels of cholesterol and the expression of the low-density lipoprotein receptor (LDLR) to enhance our understanding of the role of the mevalonate pathway in cancer cholest

Studies of human endogenous retroviruses and of the TGF-beta signaling pathway

The human genome, in common with all mammalian genomes, carries a high load of inheritable retroviral sequences. We have identified and characterized a novel family of these endogenous retroviruses and have named this family HERV-F as based on the primer binding sites of three members. The HERV-Fs are C-type endogenous retroviruses that have unique gag, pol and env regions that are, based on phylo

En europeisk apokalyps? Om Viktor Rydbergs 'Den hvita rasens framtid'

Summary In 1895 a posthumous essay by the Swedish poet and scholar Viktor Rydberg (1828- 1895) was published with the, for many modern Europeans, provoking title Den hvita rasens framtid (“The future of the white race”). In the late 20th century however “the white race” was a commonly used expression, it did not indicate any right-wing sympathies. Rydberg himself was a leftist, a social liberal. C

Dynamic Power System Load -Estimation of Parameters from Operational Data

The significance of load modeling for voltage stability studies has been emphasized by several disturbances, which have taken place in the past years. They have shown that the loads in combination with other dynamics are among the main contributors of prolonged low voltage conditions, voltage instability and collapse in the power system. As a result of these disturbances new investigations have co

RoSiB - a 4 pi silicon ball for charged-particle detection in EUROBALL

A 4 pi silicon bail for detection and identification of light charged particles in large multidetector gamma-arrays as EUROBALL is presented. The design is based on a N = 42 ball with 12 pentagons and 30 hexagons as used in the GASP array. The absorptive material for gamma-rays is minimized to the detector thickness of 300 or 500 mu m and a 0.63 mm ceramic backing. The geometrical coverage is desi

Improving Incident Reports in the Swedish Armed Forces

It is generally maintained that learning should be a part of the daily routines of many organizations; this is often referred to as lesson learned processes. The purpose of organizational learning is to foster improvements that seek to both reduce incidents and accidents and reduce their consequences when they nevertheless happen. Safety work is widespread among many organizations, e.g. aviation,

One-year results of the SCANDIV randomized clinical trial of laparoscopic lavage versus primary resection for acute perforated diverticulitis

Background: Recent randomized trials demonstrated that laparoscopic lavage compared with resection for Hinchey III perforated diverticulitis was associated with similar mortality, less stoma formation but a higher rate of early reintervention. The aim of this study was to compare 1-year outcomes in patients who participated in the randomized Scandinavian Diverticulitis (SCANDIV) trial. Methods: Be