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Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t

Background: Paediatric surgical care is increasingly being centralized away from low-volume centres, and prehospital delay is considered a risk factor for more complicated appendicitis. The aim of this study was to determine the incidence of paediatric appendicitis in Sweden, and to assess whether distance to the hospital was a risk factor for complicated disease. Methods: A nationwide cohort stud

Background: Sentinel lymph node biopsy (SLNB) is standard staging procedure for nodal status in breast cancer, but lacks therapeutic benefit for patients with benign sentinel nodes. For patients with positive sentinel nodes, individualized surgical strategies are applied depending on the extent of nodal involvement. Preoperative prediction of nodal status is thus important for individualizing axil

Bullous pemphigoid (BP) is an autoimmune bullous disease, associated with autoantibodies directed against the hemidesmosomal components BP180 and BP230. In this study for the first time different laboratories have analyzed the autoantibody profile in the same group of 49 prospectively recruited BP patients. The results show that: 1) disease severity and activity correlated with levels of IgG again

Successful conservation of large carnivores can only be achieved if the side effects of carnivore presence and protection are mitigated, allowing development of sustainable agricultural practices in the local society. A core element of large carnivore management is the mitigation of carnivore attacks on livestock or dogs. However, whilst attacks may be rare, the domestic animals and their owners w

In five primary hip arthroplasties and in six revisions with impacted, morselized allografts and cement, roentgen stereophotogrammetric analysis (RSA) was planned to be used to measure the subsidence of the polished and double-tapered Exeter femoral stem, relative both to the cement and the femur. Only in two primary arthroplasties and in two revisions could the tantalum markers be adequately imag

A high-resolution 270-MHz proton NMR study of procine colipase I has been performed, and the resonances in the aromatic region of the spectrum have been assigned to amino acid residues by pH titration and decoupling experiments. The apparent pKa values of the three tyrosines were calculated to be 10.2, 10.3, and 11.8 with one of the tyrosines having properties of a “buried” residue. A tentative as

The purpose of this study was to explore retina-intrinsic neuroinflammatory reactions, effects on neuronal survival, relationship with classic gliosis, and possible role of the toll-like receptor 4 (TLR4). To isolate the adult retina from the systemic immune system, a previously described large animal explant culture model was used in which full-thickness porcine retinal sheets can be kept in vitr

The effects of plasmapheresis on islet autoantibody levels, C-peptide (β-cell function), and hemoglobin-A1c (HbA1c, metabolic control) were tested in a prospective blinded study of 18 newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients randomly assigned to receive plasmapheresis (P), carried out as double filtration, or sham (S) treatment at diagnosis and 3 months thereafter. At di

Background: Positive psychology indicators like well-being and life satisfaction may play a pivotal role in pain-related outcomes. In this study, we aimed to examine the prospective associations of positive well-being and life satisfaction with pain severity. Methods and Subjects: This longitudinal study, with a follow-up of 2 years, included 9361 participants (4266 males, 5095 females; mean age:

INTRODUCTION: Resent research has revealed an increased concentration of free fetal hemoglobin (HbF) in maternal serum from patients who subsequently develops preeclampsia (PE). In a previous study of 96 patients we have shown that HbF in combination with the heme-scavenger alpha-1-microglobulin (A1M) are potential predictive biomarkers of PE.OBJECTIVES: In this validating case-control study we ai

In 2007, Brandforsk – the Swedish Fire Research Board – initiated a research program to provide an overview of research needs coupled to ”arson” in Sweden. A total of six different Swedish universities and research institutes were involved in different projects in the research program. These projects involved both technical aspects fire detection and fire compartmentation as well as sociological i

Selective depletion of nerve growth factor receptor-bearing neurons in the basal forebrain cholinergic system nuclei by the immunotoxin 192 IgG-saporin offers a new and highly useful tool for the study of the role of the forebrain cholinergic system in cognitive functions. In the present study, we have tested the effects of 192 IpG-saporin in an operant delayed matching-to-position task which has

The incorporation of a free fatty acid into the sn-1 position of phosphatidylcholine by lipase-catalyzed transesterification was investigated. The thermodynamic water activity of both the enzyme preparation and the substrate solution was adjusted to the same value prior to the reaction. The reaction rate increased with increasing water activity but the yield of modified phosphatidylcholine decreas

Invasive alien species threaten biodiversity with domestic gardens acting as a major pathway for the introduction of alien species. Even though the Nordic region is not currently a hotspot for biological invasions, the number of invasions in the Nordic area has been predicted to increase due to climate change. Given a time lag between introduction and invasion, many non-invasive horticultural alie

This chapter strikes a bridge from current-day imaginations to pre-modern concepts of empire. It shows how, on the one hand, modern visions of empire are echoing political and religious notions of an all-encompassing rule that go back to Antiquity. On the other hand, it stresses how such modern conceptualizations tend to fall short on understanding diversity in a world where state penetration and

Objective. Psoriatic arthritis (PsA) prevalence estimates vary across studies; studies based on national data are few. We aimed to estimate the prevalence of clinically diagnosed PsA in Sweden in 2017, overall and stratified by sex, age, education, and geography, and to quantify disease-modifying antirheumatic drug (DMARD) use among those in contact with specialized rheumatology care between 2015

Across the boreal biome, clear-cutting of old, previously non clear-cut forests with high naturalness followed by tree planting or seeding is a major land use change. However, how much previously uncut forest has been converted to plantations remains unquantified. We combine Swedish national databases on clear-cuts and forest inventories to show that at least 19% of all clear-cuts since 2003 have

Background: Previous studies have reported an inverse association between educational attainment and different osteoarthritis (OA) outcomes. However, none of the previous studies have accounted for potential confounding by early-life environment and genetics. Thus, we aimed to examine the association between educational attainment and knee and hip OA surgery using twin data. Methods: From the Swed

Human–wildlife interactions occur when humans and wildlife overlap in the same landscapes. Due to the growing human population, the number of interactions will continue to increase, and in some cases, develop further into social conflicts. Conflicts may occur between people disagreeing about wildlife conservation or arguing over which wildlife management measures should be taken. Social conflicts