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The standard treatment of glioblastoma, an aggressive brain tumour, includes radiotherapy combined with temozolomide. Based on a randomised trial, showing five months increased survival, TTF has been introduced in the management of patients with good performance status. Data from the Swedish national quality registry for CNS tumours have been analysed for TTF usage. The results demonstrate that 65
Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors. PGLs can further be divided into sympathetic (sPGLs) and head-and-neck (HN-PGLs). There are virtually no treatment options, and no cure, for metastatic PCCs and PGLs (PPGLs). Here, we composed a tissue microarray (TMA) consisting of 149 PPGLs, reflecting clinical features, presenting as a useful resource. Mutations
Cisplatin, a platinum-based chemotherapeutic agent, is widely used as a front-line treatment for several malignancies. However, treatment outcomes vary widely due to intrinsic and acquired resistance. In this study, cisplatin-perturbed gene expression and pathway enrichment were used to define a gene signature, which was further utilized to develop a cisplatin sensitivity prediction model using th
CysK1 and CysK2 are two members of the cysteine/S-sulfocysteine synthase family in Mycobacterium tuberculosis, responsible for the de novo biosynthesis of L-cysteine, which is subsequently used as a building block for mycothiol. This metabolite is the first line defense of this pathogen against reactive oxygen and nitrogen species released by host macrophages after phagocytosis. In a previous medi
An accident on a passenger ferry may lead to evacuation using lifeboats or liferafts, a process that can be both complex and hazardous. This paper investigates the level of safety for passengers during evacuation based on field study and interview data. In the analysis, the eight goals of Universal Design (UD) were tailored and used to explore what ship and interior characteristics influence evacu
This work presents a new approach to the autotuning strategy for controlling pH in raceway reactors, based on classical relay-based autotuning principles. A relay applied to reference method is proposed that allows seamless integration into existing control loops without the need for manual recalibration across seasons or operator intervention. Two different models were identified: first-order wit
The goal of this study was to get the first-line managers in municipal elderly care view on the relationship between them and their employees, what kind of factors matter when building the relationship, and also how different styles of leadership could affect the process. The selection of participants was chosen by finding first-line managers in municipal elderly care within driving distance from
All government controlled business is controlled by the law of public procurement and its five fundamental principles. If these are not fulfilled the procurement is at risk of being subject to a review procedure, which requires both time and money. Therefore it is important to ensure the quality of these processes for contracting authorities such as Region Skåne, especially in conjunction with the
Could the use of CSA practices stabilize the hunger crisis? Despite the general understanding that CSA practices increase farmers' food security, its resilience to climatic shocks is much less understood. To address this gap, this study analyzes the effect of three CSA practices: inorganic fertilization, intercropping and improved seeding on maize productivity in Ethiopia, Tanzania, and Uganda
This study analyses the relationship between the vision for education in Uganda through indigenous NGOs, the state of Uganda, and the United Nations. Investigation of whether they are consensual or constitute a discrepancy and what consequences that indicate, is also investigated. The material consists of the vision statement for education from 58 indigenous NGOs, the state document Uganda Vision
The thesis researches opinion representation in Sweden in regards to the EU, with the goal of finding out if Swedish voters are represented in regards to the EU. This is done by researching what the Swedish voters’ as well as the Swedish politicians’ opinions are on increased European integration. Theories of representation and opinion representation are presented. Two different studies are compar
Uppsatsens syfte är att undersöka utvecklingen av efterlevande makes arvsrätt i Finland och Sverige under 1900-talet, med fokus på argumentationen bakom den. De är två länder med nära historiskt, samhälleligt och kulturellt samband, vilket gör rättshistorien och jämförelsen intressant. Utvecklingen startade från att makarna inte hade någon arvsrätt alls i länderna och gick hand i hand ända fram tiThe purpose of this paper is to study how the surviving spouse’s inheritance rights in case of death of the other spouse have developed during the twentieth century in Finland and Sweden. The focus will be on the arguments behind the legislations and how they developed during the reforms over the years, and how they differ, or don’t, between the two countries. Due to the countries’ shared history
Nationalparker utgör ett centralt element i naturvård runt hela jorden. Utöver naturvård så utgör tron på deras positiva effekt för regionalekonomisk utveckling en allt vanligare motivering för att grunda nya nationalparker. Forskningsläget kring omfattningen av sådana effekter är dock oklart och den ekonomiska effekten av nationalparker i Syd-, Väst, och Mellansverige har inte analyserats i någonNational parks are key parts of worldwide conservation initiatives. Increasingly, they are being founded not only to meet conservation goals but also because of their potential positive impact on regional economies. However, the results of previous research are ambiguous when it comes to assessing the magnitude of this effect and no such studies have been conducted for national parks in southern,
The growing popularity of Artificial Neural Networks (ANN) demands continuous improvement and optimization of the training process to achieve higher-performing algorithms at a lower computational cost. During training an ANN learns to solve a problem by looking at examples, and will iteratively go over a dataset to reach an optimal performance. Usually the user needs to define a fixed number of it
Democracy is both a question of who the people are (demos) and how they rule (kratos); our understanding of democracy is imbalanced in favour of the latter. The aim of this thesis is to conduct a pilot project evaluating and comparing the level of democracy from a demos perspective through an index. The findings of a research review establishes the theoretical foundation of the index, which is the
The following study delves into the congruence of three major IR theories. Constructivism, liberalism and realism. It delves into this congruence by testing their compatibility under a single analytical framework. To best highlight these theories overlapping sides I have chosen to find variants of the theories that I believe to be most similar to one another. Furthermore, an idea analysis is condu
Här beskrivs min strategi för att omvandla en befintlig byggnad kallad Žižkov Freight Railway Station till en multifunktionell byggnad. Denna komplex är belägen i Prag, Tjeckien, och byggdes färdigt 1936. Byggnaden är ett utmärkt exempel på funktionalism från tiden och regionen, men tyvärr har komplexet delvis varit övergivet sedan 2002. Därmed finns det flera tecken på försämring genom hela byggnThis document details my approach to turning an existing building called Žižkov Freight Railway Station into a multifunctional building. This complex is located in Prague, Czech Republic, and dates from the year 1936. It is an excellent example of functionalism from the time and region but, sadly the complex has partially been abandoned since 2002. Consequently, there are multiple signs of deterio
Germany is generally considered to be a country that is free trade friendly and had, at the start of the TTIP negotiations, a majority in favour of TTIP. Now however, Germany has amongst the lowest levels of public support of TTIP of all EU member states, while a majority at the same time remain positive of international trade and even increased trade with the US. Previous studies have shown that
