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The recombinant xylose-utilizing Saccharomyces cerevisiae TMB 3399 was constructed by chromosomal integration of the genes encoding Image-xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase (XK). S. cerevisiae TMB 3399 was subjected to chemical mutagenesis with ethyl methanesulfonate and, after enrichment, 33 mutants were selected for improved growth on Image-xylose and carbon dio

Background: Considerable lives and money could be saved if one could detect early stages of lapsing/ relapsing behavior in addicted persons (e.g., in safety-sensitive workplaces) and could disclose harmful drinking in social drinkers. Due to the serious public health problem of alcohol use and abuse worldwide, markers of alcohol use have been sought. Both ethyl glucuronide (EtG) and phosphatidyl e

Popular Abstract in Swedish Många beständighetsproblem uppträder i gränsytor mellan material. Exempel är lossfrysning av puts på tegel, avflagning av färg, sprickbildning hos ytskikt, vidhäftningsbrott mellan reparationsmaterial och underlag. I nästan alla fall är nedbrytningen kopplad till alltför höga fuktnivåer i gränsytan. Flera beständighetsproblem, t.ex. frostnedbrytning, uppstår enbart om mThe main impetus for this research was the desire to verify models for determining transient moisture profiles in the capillary range. For the evaluations, transient moisture profiles were both simulated and measured, after which the results of the two methods were compared. The study was performed for on specimens exposed to continuous water absorption, using specimens of both single and combined

Popular Abstract in Swedish Inom svensk mjölkproduktion förekommer en hög frekvens av belastningsbesvär. Vid jämförelser mellan manliga och kvinnliga mjölkare har det visat sig vara stora skillnader avseende besvärsförekomst. Kvinnorna har rapporterat högre frekvens av problem i nästan alla kroppsdelar jämfört med männen. Dessutom har andelen hand- och handledsbesvär visat sig vara anmärkningsvärdThe aims of the thesis were to investigate the prevalence of the upper extremity musculoskeletal disorders in female milkers in relation to other occupational groups; to clarify the relationship between disorders and work environment, psychosocial and life style factors; to compare in a prospective study, pain, ache and discomfort reported by a questionnaire with clinical symptoms and sign; to exa

The main topic of this thesis is the investigation of small molecules adsorbed on metal surfaces by means of core-level photoemission spectroscopy. The thesis consists of three parts; The first group of papers concerns the effects of internal molecular vibrations on the core-level photoemission spectra. The second and third groups of papers concern more basic adsorption properties, like adsorption

1. It has been suggested that the vasoconstrictor response to neuropeptide Y (NPY) is located in the microvessels and that it increases with reduced vessel diameter. The aim of the present study was to analyse quantitatively, on the cat gastrocnemius muscle preparation in vivo, the effects of NPY on total regional vascular resistance (RT) and its distribution to large-bore arterial resistance vess

Popular Abstract in Swedish I vår kropp står ämnesomsättningen för nedbrytning av mat till kemiska ämnen som är nödvändiga för vår energiförsörjning, kroppsuppbyggnad och fortplantning. Varje cell i varje organism tillverkar eller tar upp små molekyler, som de sedan sätter ihop till stora molekyler. Samtidigt som detta sker så bryter cellerna ner molekyler som har blivit tillverkade. Ur detta får There are two fundamentally different ways by which a metabolite can be transferred between enzymes in metabolic pathways. If the two sequential enzymes cannot form a complex with each other, the metabolite must first be released from the producing enzyme to the reaction medium and then be transported to the consuming enzyme, via the reaction medium, by free diffusion. If the two sequential enzyme

OBJECTIVE: To compare the effects of green foam with black foam and gauze during negative pressure wound therapy (NPWT), with regard to wound bed appearance and granulation tissue formation, and monitoring of wound exudate. METHOD: Wounds on the backs of eight pigs underwent 72 hours of NPWT plus either green polyurethane foam with an open pore structure, black polyurethane foam with an open pore

PURPOSE Chronic myeloid leukemia (CML) management changed dramatically with the development of imatinib mesylate (IM), the first tyrosine kinase inhibitor targeting the BCR-ABL1 oncoprotein. In Sweden, the drug was approved in November 2001. We report relative survival (RS) of patients with CML diagnosed during a 36-year period. PATIENTS AND METHODS Using data from the population-based Swedish Can

Wetland creation at large, regional scales is implemented as a measure to abate the biodiversity loss in agricultural landscapes and the eutrophication of watersheds and coastal areas by non-point source nutrient pollution (mainly nitrogen). The consequences of creating many new wetlands for biodiversity conservation and nutrient retention (ecosystem functioning) in agricultural landscapes are sti

The thesis describes the neural precursor cell line RN33B transplanted subretinally to adult healthy and young dystrophic rat retina. The cell line is generated from E12,5 rat raphe nucleus and transduced with the temperature sensitive mutant of the Simian Virus 40 (SV40) large T-antigen. The transplanted cells can be detected by the reporter genes for beta-galactosidase (beta-Gal) and the green f

Sot är en produkt som kommer ifrån ofullständig förbränning av olika bränslen, som fossila bränslen och biogaser. Sot produceras därför, bland annat, i många av våra fordon, så sot släpps ut i stora mängder. Sot har en negativ påverkan på miljö och mänsklig hälsa. Det finns olika typer av sot. De som absorberar ljus bättre och har större klimatpåverkan kallas moget sot, medan sot med sämre ljusabsSoot is a known contributor to climate change due to its strong light absorption possibility. It has been shown that adding alkali salts during the soot formation reduces its soot absorption ability, and thus reduces its impacts, but the exact mechanics are not fully understood. This thesis aims to get a better understanding of the effects that salts have on soot. The salts used were sodium chlori

Introduction: PARP15 belongs to the PARP family, which carries out ADP-ribosylation, a post- translational modification involved in DNA repair. Finding selective inhibitors can help discover more of the role PARP15 plays in our body. Background: Inhibitors of other PARP family members, such as PARP1, have been studied because of their role in cancer processes. However, PARP15 remains poorly charac

High-grade serous carcinoma (HGSC) accounts for most ovarian cancer deaths, due to it often being diagnosed at late stages (III and IV). However, there is currently no early screening method sufficient for improving survival rates. HGSC primarily harbors structural variants, typically copy number (CN) aberrations caused by homologous recombination deficiency (HRD). CN can be calculated based on re

Background: Logistics within the food industry have been under increased pressure in recent years due to factors such as the invasion of Ukraine and Covid-19. This has put additional focus on efficiency throughout the supply chain, including warehousing activities. Warehousing has historically often been seen as a burden as it provides limited value-adding activities which means organizations cons

This thesis examines the causes and effects of the 1762 prohibition introduced by the Swedish diet against the collection of seabird eggs. The study lies at the intersection of environmental, political, animal, and hunting history, focusing on environmental regulations concerning huntable species imposed by political authorities. Previous research has largely accepted the prohibition as a given, w

In order to study the influence of the weather on the snowmelt in the Tarfala Valley, a survey of the runoff from the snow in the valley, was performed in May and June 1988, at the Tarfala Research Station. The aim of the survey was to find a simple numerical model that corresponds well to the runoff from the snow and to identify reasons for deviating runoff in different places. The survey was bas

Abstract Title: What is specific about e-tailers’ internationalisation? The intertwinement of internationalisation, management of the marketing mix and consumers’ perceptions. Date of the Seminar: June 2nd, 2022 Course: BUSN39 Degree Project in Global Marketing Authors: Íris Einarsdóttir and Sandra Marín Gunnarsdóttir Advisors: Ulf Elg Keywords: Internationalisation, marketing mix, e-tailer

The purpose of this study is to understand how multiple actors from the same business sector perceive operating on a campus setting. The main focus is on the relationships between tenants on-campus, as well as on identifying potential derived from the location on-campus. The study is a qualitative case study of two health and wellbeing campuses in Finland. The cases share some key characteristics,

Secondary organic aerosol (SOA) forms a major part of the tropospheric submicron aerosol. Still, the exact formation mechanisms of SOA have remained elusive. Recently, a newly discovered group of oxidation products of volatile organic compounds (VOCs), highly oxygenated organic molecules (HOMs), have been proposed to be responsible for a large fraction of SOA formation. To assess the potential of