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Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as fragments. We immunoprecipitated tau from CSF and identified several endogenous peptides ending at amino acid (aa) 123 or 224 using high-resolution mass spectrometry. We raised neo-epitope-s

The association between somatic cell count (SCC) and daily milk yield in different stages of lactation was investigated in cows free of clinical mastitis (CM). Data were recorded between 1989 and 2004 in a research herd, and consisted of weekly test-day (TD) records from 1,155 lactations of Swedish Holstein and Swedish Red cows. The main data set (data set A) containing 36,117 records excluded TD

Importance: General practitioners (GPs) sometimes initiate a treatment despite not expecting it to improve patients' symptoms by any physiological mechanism. These essentially placebo treatments are ethically controversial, and their frequency is unclear. They involve risks for patients, but to estimate these, more data are needed. Objective: To develop a more precise overview of the rate at which

Introduction: Prenatal exposure to inflammatory states has been suggested to influence offspring neurodevelopment. The aim was to investigate if offspring exposure to maternal Inflammatory bowel disorder (IBD), or specifically the IBD disorder Crohn's disease, during gestation is associated with neurodevelopmental or psychiatric disorders in childhood. Material and Methods: We conducted a populati

BACKGROUND: Prognostic stratification is essential for guiding treatment and follow-up in cutaneous melanoma. Previous international studies suggest that patients with localized stage IIB and IIC melanoma have poorer survival rates than those with lymph node involvement in stage IIIA. Nevertheless, Swedish guidelines still recommend less frequent follow-up for stage II than for stage III melanoma

AIMS/HYPOTHESIS: MicroRNAs are potential predictors and mediators of metabolic disease. Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in cystic fibrosis (CF). Here we aimed to investigate serum microRNAs in individuals with CF and differing glucose tolerance status. Specifically, we hypothesised that the circulating microRNA profile varies depending on glucose tolerance st

Error estimation and data fusion are critical to improving the accuracy of global model- and satellite-based precipitation products for practical applications. However, they face challenges over vast areas of the world due to limited ground observations. Triple collocation (TC) method can overcome this limitation and provide an efficient way for error estimation without the “ground truth” and thus

The accurate evaluation of shifts in vegetation phenology is essential for understanding of vegetation responses to climate change. Remote-sensing vegetation index (VI) products with multi-day scales have been widely used for phenology trend estimation. VI composites should be interpolated into a daily scale for extracting phenological metrics, which may not fully capture daily vegetation growth,

Soil microorganisms play an integral role in the regulation of carbon (C) cycling. In high-latitude ecosystems, climate warming is leading to higher plant productivity, shrub expansion and faster nutrient cycling; all of which increase resource availability to soil microorganisms. To understand how a legacy of enhanced resource availability affects the functional traits of microbial communities, a

Background: Changes in grey matter covariance networks have been reported in preclinical and clinical stages of Alzheimer’s disease (AD) and have been associated with amyloid-β (Aβ) deposition and cognitive decline. However, the role of tau pathology on grey matter networks remains unclear. Based on previously reported associations between tau pathology, synaptic density and brain structural measu

Introduction: Cardiotocography (CTG) is the main method of intrapartum fetal surveillance. In 2015 a new guideline was introduced by the International Federation of Gynecology and Obstetrics (FIGO), FIGO-15. In Sweden it was adjusted to SWE-17, replacing the previous national template, SWE-09. This study, conducted at one university hospital and one regional hospital in southern Sweden, evaluated

BACKGROUND: Cerebrospinal fluid (CSF) clearance via the olfactory pathway is well-documented in animal models. However, results from in vivo human studies appear inconsistent. Studies using intrathecal (IT) Gadolinium-based contrast agents (GBCA) enhanced MRI showed minimal tracer pass-through from intracranial to extracranial olfactory regions such as the nasal mucosa. Conversely, human imaging s

Plast är ett av våra vanligaste material i vardagen. Som helhet är det ett billigt, slitstarkt och lätt material. Det finns olika typer av plast med olika egenskaper. Gemensamt för alla plaster är dock att de består av (oftast en typ av) molekyler som sitter ihop i långa, repeterande kedjor. Dessa kedjor kallas polymerer. När plast slängs i naturen eller hanteras fel som avfall finns det en risk aAs plastic pollution in aquatic environments persists, gaining a deeper understanding of nanoparticles has become increasingly important. Yet, the question remains: what happens to plastic as it breaks down into smaller components, and ultimately, what end products are formed? Current plastic degradation methods are limited in their environmental applicability and efficiency. This study aims to pr

ImportanceThe management of complications following oral cavity squamous cell carcinoma (OCSCC) surgery can be challenging. Previous studies show conflicting results on complication risks after preoperative radiotherapy (RT), necessitating a randomized controlled trial (RCT).ObjectiveTo compare early complications during hospitalization for OCSCC surgery between patients receiving preoperative acc

Background: Obstetrical anal sphincter injuries are complications of vaginal birth that have the potential to cause substantial maternal morbidity. Predicting these injuries might help to improve maternal care as well as antenatal counseling and patient education. Previous attempts to create prediction models have in many cases involved variables only known postpartum, which limits their use in an

INTRODUCTION: There are few recent studies on trends over time in functional outcome and mortality after stroke, with results separately presented for ischaemic stroke (IS) or ICH. We aimed to determine temporal changes in functional outcome and case-fatality 90 days after IS and ICH in Sweden between 2010 and 2019. PATIENTS AND METHODS: We included patients (≥18 years) with first-ever IS or ICH r

Comparison of ROS production of individual particle components from traffic-related sources can inform new health policies and emissions legislation. This work aims to quantify acellular ROS production and oxidative potential (OP) of such individual particle components from combustion, brake, tire, and road wear. Particle characteristics are probed to identify source-specific markers and improve t

Centre for Retail Research at Lund University ANNUAL REPORT | 2018 2 ANNUAL REPORT CENTRE FOR RETAIL RESEARCH AT LUND UNIVERSITY 2018 3 ANNUAL REPORT CENTRE FOR RETAIL RESEARCH AT LUND UNIVERSITY 2018 Introduction Centre for retail research – the fifth year The centre for retail research has now been in existence for five years and, during the past year, we have wrapped up se- veral research proje

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-01/annualreport-2018.pdf - 2026-05-25

Objectives The Patient Health Questionnaire-9 (PHQ-9) is one of the most commonly used measures for screening, diagnosing and monitoring of depression. So far, four studies have examined some of the psychometric properties of Persian version of PHQ-9 in physical and psychiatric patients; however, some aspects of its psychometrics have not yet been adequately evaluated in the student population. Th