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Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies

The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain specific or more broadly protective. Here, we quantified the opsonic-antibody response following invasive S. pyogenes infection. Four patients with S. pyogenes bacteremia between 2018 and 2020 at Skåne Uni

Bureaucratic Reforms as Triggers of Experimental Design : KBS and Public Building in Sweden, 1963–74

This article explores the relationship between architecture and public administration at the Swedish National Board of Public Building (Kungl. Byggnadsstyrelsen, or KBS) in the years 1963–74. This government agency, which existed from 1918 to 1993, was in charge of planning, designing, producing and maintaining public service buildings and facilities. During the 1960s, it was subject to a number o

Early diagnosis, treatment, and Health-Related Quality of Life in women with mild Breast Cancer-Related Lymphedema.

Bakgrund: Tidig diagnos och behandling av bröstcancer-relaterade lymfödem(BCRL) är viktigt för att förhindra försämring och påverkan på livskvalitet. Vidmindre BCRL i arm, kan det ansamlas lymfvätska lokalt i den ytliga vävnaden, utan en volymökning. Tissue Dielectric Constant (TDC), är en metod som mäter lokal vävnadsvätska i hud och subkutan vävnad och hade inte använts tidigare för att diagnostBackground: Early diagnosis and treatment of Breast Cancer-RelatedLymphedema (BCRL) are important to prevent lymphedema progress and impacton Health-Related Quality of Life (HRQOL). The treatment includes self-care andtreatment with compression garment. In mild BCRL, the lymphedema can be local, without an increase in arm volume. Tissue Dielectric Constant (TDC), measuring local tissue water in sk

Predicting wear mechanisms of ultra-hard tooling in machining Ti6Al4V by diffusion couples and simulation

Conventional cemented carbide is recommended for machining Ti6Al4V. However, polycrystalline diamond (PCD) and polycrystalline cubic boron nitride (pcBN) also show promise. Demands for higher productivity accelerate diffusional dissolution and chemically driven wear mechanisms in these tool materials. This study investigates active wear mechanisms by studying the interactions between Ti6Al4V and P

The potential role of retinal cGMP-interaction partners within the degeneration mechanism causing Retinitis Pigmentosa

The eye disease Retinitis Pigmentosa (RP) represents a heterogeneous group of inherited retinal dystrophies, and it has been estimated that 1 in 3000 to 7000 people worldwide has the disease. The symptoms of RP are photoreceptor degeneration that leads to night blindness, followed by a decline in peripheral and central vision, and potential blindness. However, the mechanism(s) behind the photorece

Local Destruction of Tumors and Systemic Immune Effects

Current immune-based therapies signify a major advancement in cancer therapy; yet, they are not effective in the majority of patients. Physically based local destruction techniques have been shown to induce immunologic effects and are increasingly used in order to improve the outcome of immunotherapies. The various local destruction methods have different modes of action and there is considerable

Microplastics in Latin America Ecosystems : A Critical Review of the Current Stage and Research Needs

The ubiquity of microplastics ecosystems has gained global attention. In this context, Latin America, which is responsible for 8% of the world's consumption of plastic material and has a small recycling rate (4.5%), does not have enough data on microplastics contamination in its environmental matrices. This systematic review analyzed 196 studies from 16 territorials in Latin America and provided i

Replication Data for : Learning to predict - second language perception of reduced multi-word sequences

This is the data and code from a word-monitoring task, in which advanced learners of English responded to the word 'to' in verb + to-infinitive structures (V-to-Vinf) in English, where 'to' could occur in a full or reduced pronunciation (e.g. "prefer to" [tʊ] or "preferda" [ɾə]). The design of this experiment is replicated from our earlier study with American English native speakers (Lorenz &

Land use and land cover change in locally supported wildlife management areas in the Nyerere-Selous ecosystem, Tanzania

Worldwide, there is conversion of natural habitats to other land cover types. These are explained by changes in land use and climate change. In Tanzania, environmental degradation happens also within and around protected areas. To mitigate the effects, wildlife management areas (WMAs) surrounding the borders of protected areas in Tanzania have been promoted. They are based on the concept of commun

Effect of High-Risk Obstructive Sleep Apnea on Clinical Outcomes in Adults with Coronavirus Disease 2019

Rationale: Coronavirus disease (COVID-19) is an ongoing pandemic, in which obesity, hypertension, and diabetes have been linked to poor outcomes. Obstructive sleep apnea (OSA) is associated with these conditions and may influence the prognosis of adults with COVID-19. Objectives: To determine the effect of OSA on clinical outcomes in patients with COVID-19. Methods: The current prospective observa

Analysis of regional CO2contributions at the high Alpine observatory Jungfraujoch by means of atmospheric transport simulations and δ13C

In this study, we investigated the regional contributions of carbon dioxide (CO2) at the location of the high Alpine observatory Jungfraujoch (JFJ, Switzerland, 3580ĝ€¯mĝ€¯a.s.l.). To this purpose, we combined receptor-oriented atmospheric transport simulations for CO2 concentration in the period 2009-2017 with stable carbon isotope (δ13C-CO2) information. We applied two Lagrangian particle disper

ProTstab2 for Prediction of Protein Thermal Stabilities

The stability of proteins is an essential property that has several biological implications. Knowledge about protein stability is important in many ways, ranging from protein purification and structure determination to stability in cells and biotechnological applications. Experimental determination of thermal stabilities has been tedious and available data have been limited. The introduction of li

Characterization of the predominant basic protein in human seminal plasma, one cleavage product of the major seminal vesicle protein

From liquefied human seminal plasma, we purified the predominant basic protein which appears following liquefaction of coagulated semen. The protein was purified in the presence of di-isopropylfluorophosphate to retard its degradation. Heparin-Sepharose® chromatography was followed by gel filtration (Biogel® P 60) and by fast performance liquid chromatography on a reversed phase column (C8). The b

The Recurring ‘Discovery’ of Hokkaido and the Ainu : Three Decades of Nineteenth-Century British Travelogues

With the full-scale colonization of Hokkaido, home to the indigenous Ainu people, by the Japanese Meiji government (1868-1912), unprecedented ethnographic opportunities emerged for Western scientists and adventure-seekers. Literally dozens of such individuals “discovered” information about the Ainu and their homeland during this period, introducing European and American audiences to the subject th

Nonlinear ultrasonic characteristics of a corroded steel plate

Corrosion in leak-tight plate structures, such as the containment liner in Nuclear Power Plants (NPPs), is detrimental to their operational state. To tackle this issue, the present work aims to assess the feasibility of using nonlinear ultrasound to detect corrosion. The corrosion product of main concern in the present study contains several microscopic and macroscopic cracks and delaminations. Th

Global, regional, and national burden of other musculoskeletal disorders, 1990-2020, and projections to 2050 : a systematic analysis of the Global Burden of Disease Study 2021

BACKGROUND: Musculoskeletal disorders include more than 150 different conditions affecting joints, muscles, bones, ligaments, tendons, and the spine. To capture all health loss from death and disability due to musculoskeletal disorders, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) includes a residual musculoskeletal category for conditions other than osteoarthritis, rheuma

Mold Odor from Wood Treated with Chlorophenols despite Mold Growth That Can Only Be Seen Using a Microscope

We previously reported that indoor odorous chloroanisoles (CAs) are still being emitted due to microbial methylation of hazardous chlorophenols (CPs) present in legacy wood preservatives. Meanwhile, Swedish researchers reported that this malodor, described since the early 1970s, is caused by hazardous mold. Here, we examined to what extent CP-treated wood contains mold and if mold correlates with

Strain and phase evolution in TiAlN coatings during high-speed metal cutting : An in operando high-energy x-ray diffraction study

We report on phase and strain changes in Ti1-xAlxN (0 ≤ x ≤ 0.61) coatings on cutting tools during turning recorded in operando by high-energy x-ray diffractometry. Orthogonal cutting of AISI 4140 steel was performed with cutting speeds of 360–370 m/min. Four positions along the tool rake face were investigated as a function of time in cut. Formation of γ-Fe in the chip reveals that the temperatur

Diffusion-weighted MR spectroscopy : Consensus, recommendations, and resources from acquisition to modeling

Brain cell structure and function reflect neurodevelopment, plasticity, and aging; and changes can help flag pathological processes such as neurodegeneration and neuroinflammation. Accurate and quantitative methods to noninvasively disentangle cellular structural features are needed and are a substantial focus of brain research. Diffusion-weighted MRS (dMRS) gives access to diffusion properties of