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Clinical and Molecular Spectrum Associated with COL6A3 c.7447A>G p.(Lys2483Glu) Variant : Elucidating its Role in Collagen VI-related Myopathies

Background: Dominant and recessive autosomal pathogenic variants in the three major genes (COL6A1-A2-A3) encoding the extracellular matrix protein collagen VI underlie a group of myopathies ranging from early-onset severe conditions (Ullrich congenital muscular dystrophy) to milder forms maintaining independent ambulation (Bethlem myopathy). Diagnosis is based on the combination of clinical presen

Infiltration of CD163-, PD-L1- and FoxP3-positive cells adversely affects outcome in patients with mantle cell lymphoma independent of established risk factors

We characterised patients with mantle cell lymphoma (MCL) with poor prognosis based on differences in immune infiltration. Different expressions of the tumour cell markers Cyclin D1 and sex-determining region Y-box transcription factor 11 (SOX11), and the immune markers cluster of differentiation 3 (CD3), CD4, CD8, CD25, forkhead box protein P3 (FoxP3), T-box transcription factor TBX21 (T-bet), pr

In Real Life (Or Elsewhere) : Om kreativa processer och parallella verkligheter i dokumentärfilm

Reality isn’t what it appears to be. Contexts are not always clear and visible. People don’t always say what they really mean. And they don’t always mean what they say. When life is your stage manager, anything can happen. I often say, life is hard, my head is harder. Making documentaries is not for the faint-hearted.This PhD project explores creative processes and parallel realities in documentar

Galectin 3 is a powerful risk predictor for recurrent coronary events in acute coronary syndrome patients

Background: Galectin 3 and ST2 are mediators and biomarkers of myocardial fibrosis and remodeling that have recently entered the clinical practice guidelines as prognostic factors in heart failure patients. Elevated galectin 3 and ST2 levels in acute myocardial infarction patients have also been associated with increased incidence of adverse events during follow-up. Purpose: We aimed to assess the

Impact assessment of policies promoting fiber-to-fiber recycling of textiles

As part of the Mistra Future Fashion Research Program, IVL Swedish Environmental Research Institute (IVL), the International Institute for Industrial Environmental Economics (IIIEE) and PlanMiljø have investigated policy options promoting (fiber-to-fiber) recycling of textile waste. The ambition was to contribute to and broaden the discussion regarding potential policy measures in the textile fiel

Spectrum of HPV types before and after treatment of cervical intraepithelial neoplasia grade 2 and 3

Background To monitor residual disease after treatment of high grade cervical intraepithelial neoplasia (CIN), cytology together with human papillomavirus (HPV) testing are commonly performed. Objectives To analyse the spectrum of HPV types before and after treatment. Study design This register-based study included 446 women treated for CIN2 or 3, where cytology samples had been HPV-tested before

Intraguild predation leads to cascading effects on habitat choice, behaviour and reproductive performance.

1.Intraguild predation (IGP) is a commonly recognised mechanism influencing the community structure of predators, but the complex interactions are notoriously difficult to disentangle. The mesopredator suppression hypothesis predicts that a superpredator may either simultaneously repress two mesopredators, restrain the dominant one and thereby release the subdominant mesopredator, or elicit differ

Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy

Basement membranes are sheet like extracellular matrices that underlie or surround many cell types. They are crucial for key cellular events such as cell migration, proliferation, survival and differentiation. Vital components of all basement membranes are laminins, heterotrimeric combinations of different laminin chain isoforms. The different laminins and their subunits largely have a development

Protection against cold in prehospital care: evaporative heat loss reduction by wet clothing removal or the addition of a vapor barrier — a thermal manikin study

Introduction: In the prehospital care of a cold and wet person, early application of adequate insulation is of utmost importance to reduce cold stress, limit body core cooling, and prevent deterioration of the patient’s condition. Most prehospital guidelines on protection against cold recommend the removal of wet clothing prior to insulation, and some also recommend the use of a waterproof vapor b

Har vi gått över gränsen? - Förändrad svensk utstationeringslagstiftning i ljuset av EUs fria rörlighet

Denna uppsats försöker att klargöra huruvida det, sedan 2007 års Lavaldom, har skett en utveckling inom EU-rätten som tillåter att stridsåtgärder används i ett ökat antal fall, och huruvida den senaste ändringen av den svenska utstationeringslagen är i samklang med nuvarande EU-rätt. Uppsatsen fokuserar på EU-rätt och svensk rätt, och folkrätten är därför utelämnad. Utstationeringsdirektivet, utfäThis thesis tries to elucidate whether, since the Laval judgment of 2007, there has been a development in EU law allowing for collective action to be used in a greater amount of cases, and whether the latest amendment to the Swedish Posting of Workers Act is in accordance with the current EU law. The thesis focusses on EU law and Swedish law, and international law is thus omitted from its scope. T

Diffusion MRI of Brain Tissue: Importance of Axonal Trajectory

Obtaining microstructural information non-invasively on brain tissue remains a challenge. Diffusion magnetic resonance imaging (dMRI) is an imaging method that can provide such information. That includes geometrical considerations of nerve cells projections, axons, that are present in the white matter of the human brain. Axons carry information encoded into electrical impulses to other cells. The

Anknytningsdoktrinen i kölvattnet av NJA 2017 s. 226 - och vad som kom istället

Skiljeförfarandet utgör det enda alternativ till domstolsförfarande som också resulterar i en exigibel dom med rättskraft. Ett avtal om skiljeförfarande utgör ett hinder mot domstolsprövning om det åberopas inför domstol. Motsvarande prövningshinder gäller för skiljenämnd om en tvistefråga som anhängiggörs skiljenämnden faller utanför skiljeavtalets tillämpningsområde, eftersom skiljenämnden då inArbitration constitutes the only alternative to a judicial proceeding in court that also results in a legally binding judgement. An arbitration agreement also constitutes a procedural impediment if reference to it is made before the court. Corresponding procedural hindrance applies to an arbitration tribunal or to an arbitrator if the matter of dispute referred to arbitration lies outside the scop

Köp utan äganderätt? - En studie av den upphovsrättsliga konsumtionsprincipen och digitala filmverk

Filmdistributionen befinner sig i en ny digital verklighet. Den snabba tekniska utveckling som har ägt rum de senaste decennierna har inneburit stora utmaningar för såväl filmindustrins affärsmodell som de upphovsrättsliga bestämmelser som reglerar skyddet för filmverk och dess upphovsmän. Ett exempel på en bestämmelse vars tillämpningsområde är oklart till följd av den nya distributionen av digitFilm distribution has found itself in a new digital reality. The swift progress of technology that has taken place during the past decades has posed major challenges for both the film industry's business model and for the copyright laws that regulate the area. An example of a regulation whose scope is unclear as a result of the new distribution of digital copies is the principle of exhaustion.

Suitability of Dynamic Latches for Sub-VT Operation

Suitability of Dynamic Latches for Sub-VT Operation Sina Borhani Soc11sbo@student.lu.se Department of Electrical and Information Technology Lund University In the past the major concerns of VLSI designers were the performance and area of electronic devices but right now because of technology scaling in CMOS and also with the substantially growth in portable computing gadgets like smart phones

Det optimala skyddsspåret

Trap roads are a part of the Swedish railway facility and resembles the safest front- and side protection at speed above 160 km/h. When designing Trap roads, some regulations needs to be followed. As these, in some cases, may be contradictory towards each other, the planners become somewhat insecure. The purpose of the master thesis has thenceforth been to clarify for the planners, as well as to w

Blockchains as a solution for traceability and transparency

Requirements from consumers and governments to produce more sustainable products have increased during recent years. Even if products are certified, one cannot make sure companies meet these requirements, since no chain of events can verify this exists. The transportation industry lacks certification and information on whether a product is transported in a sustainable way. The food industry, on th

Effektiv projektering av broar

Marknaden för brobyggnad i Sverige är idag så god att företagen tvingas tacka nej till förfrågningar på grund av tidsbrist. Det är svårt att rekrytera nya konsulter eftersom det råder brist på arbetskraft med rätt kompetens, för att undvika att tacka nej till arbete är en potentiell lösning på tidsbristen att effektivisera arbetet. I samarbete med Skanska Tekniks brogrupp i Malmö utreder därför deThe bridge construction industry in Sweden is prospering. The situation is such that companies are forced to decline work due to lack of time. In addition, the recruitment of new consultants has been difficult owing to a shortage of labour with the right competency. To avoid the situation where companies are forced to decline new projects due to lack of resources, focus should be on improving the

Utländska barns rätt till utbildning i Sverige

De barn och ungdomar som nyligen kommit till Sverige är ingen enhetlig grupp utan består av barn med olika ursprung, som också har olika skolbakgrund. Under senare tid har flyktingströmmen till Sverige ökat markant och vi har under 2015 tagit emot ca 50 000 barn i åldern 7-17 år. Utöver dessa barn har även ett stort antal EU-migranter kommit till Sverige i enlighet med den fria rörligheten. Vad soThe children and adolescents who recently have come to Sweden are not a homogenous group. The group consists of children with different origins and they also have different educational background. Recently the level of refugees coming to Sweden has risen significantly, and during 2015 Sweden have received approximately 50 000 refugee children in the ages 7- 17. Besides the refugee children there a

The perceived innovativeness of the manufacturing process and perceived product quality. The case of creative and technology-intensive industries.

Title: The perceived innovativeness of the manufacturing process and perceived product quality. The case of creative and technology-intensive industries. Course: BUSN39 Degree Project in Global Marketing Authors: Federica Piccone & Joanna Pilawa Supervisor: Javier Cenamor Keywords: manufacturing process; perceived innovativeness; perceived quality Thesis Purpose: The main purpose is to