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Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical trials in melanoma; however, 50-60% of the patients have no clinical benefit. Here, we searched for predictive biomarkers to ACT in melanoma. Whole exome-and transcriptome sequencing and neoantigen prediction were applied to pre-treatment sample

A fully automatic system for abdominal organ segmentation is presented. As a first step, an organ localization is obtained via a robust and efficient feature registration method where the center of the organ is estimated together with a region of interest surrounding the center. Then, a convolutional neural network performing voxelwise classification is applied. The convolutional neural network co

Loess–palaeosol sequences (LPS) represent one of the most important continental archives of late Quaternary environmental change in Europe. Establishing reliable chronologies is essential for reconstructing dust dynamics and for correlating regional loess stratigraphies. In this study, we present the first systematically derived mass accumulation rate (MAR) dataset for six key Polish LPS, based on

Ställningsfullmakt är en viktig fullmakt som kommer till uttryck i 10 § andra stycket avtalslagen. Enligt regeln kan en person vara behörig att företa rättshandlingar för huvudmannens räkning på grund av att fullmäktige intagit en viss ställning genom avtal med huvudmannen. Exempelvis är ett butiksbiträde genom sin anställning behörig att motta betalning från butikens kunder för butikägarens räkniImplied authority is an important form of power of attorney that is expressed in the 10 §, second paragraph, Contract Act. According to this law, a person (the agent) can have the authority to perform legal transactions on behalf of an organization through his position in the company. For example, a store clerk is through his employment authorized to receive payment from clients on behalf of the s

This study presents a survey of the most important techno-economic factors for the implementation of biorefineries based on agricultural residues, in the form of straw, and biochemical conversion into ethanol and biogas, together with production of electricity and heat. The paper suggests locations where the necessary conditions can be met in Sweden. The requirements identified are regional availa

The fatty acid specificity of five lipases towards eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was evaluated in the hydrolysis of fish oil, squid oil and a model system. The model system contained methyl esters of EPA, DHA and palmitic acid. All the investigated lipases discriminated against both EPA and DHA more in the model system than in the natural oils. Thus both EPA and DHA we

Header 1 1 Peer-reviewed publications [1,2] [3-89] 1. K. Markenroth Bloch, Quantifying CSF Flow with Phase Contrast Techniques, Neuroimaging Clinics of North America:35, (2025), https://www.sciencedirect.com/science/article/pii/S1052514924001084, https://doi.org/10.1016/j.nic.2024.12.006 2. A. Glans, L. Wennberg, J. Wilén, L. Lindgren, P. C. Sundgren, J. Mårtensson, K. Markenroth Bloch, B. Hansson

https://www.lbic.lu.se/sites/lbic.lu.se/files/2025-03/publicationlist_20250325_kmb.pdf - 2026-06-01

Migration does have a time, energy or mortality cost, and the strategy to minimise the costs shapes the migration behaviour. Depending on the relative influence of these costs in shaping the migration, an animal is expected to undertake these journeys in different ways, depending on their morphology and migration ecology. I investigated if five Tringa-type waders minimise their migration time, and

Nanocrystalline AlxCoCrFeNi (x = 0, 0.3, 0.6, 1 mol) high-entropy alloys were synthesized by mechanical alloying (MA) and consolidated by spark plasma sintering (SPS). Single-phase face-centered cubic (FCC) structure was achieved with x = 0 and 0.3. Dual-phase body-centered cubic (BCC)/B2 + FCC structure was obtained in x = 0.6 and 1. Complete solid solution was achieved with a significantly reduc

Interest in Jane Austen’s fiction and life has never been greater than today. Her narrative works and worlds live on 200 years after their publication not only through their own popularity, but also through numerous re-presentations in the forms of novels, movies, television series, and fan fictions that keep flourishing from her fictional worlds and characters. Austen’s novels, her settings, and

Background: Geant4, a Monte Carlo Simulation Toolkit extensively used in bio-medical physics, is in continuous evolution to include newest research findings to improve its accuracy and to respond to the evolving needs of a very diverse user community. In 2014, the G4-Med benchmarking system was born from the effort of the Geant4 Medical Simulation Benchmarking Group, to benchmark and monitor the e

Late radiation-induced kidney toxicity limits molecular radionuclide therapy using radiopharmaceuticals such as 177Lu-octreotate and 177Lu-octreotide. Better kidney protection would allow higher amounts of radiopharmaceutical to be administered. Coadministration of recombinant human alpha-1-microglobulin (rA1M) has been suggested to protect kidneys from exposure from 177Lu-octreotate. Furthermore,

Trelleborg fortresses – the dream architecture of the Viking Age. In 1934, few decades after the idea of the existence of Jomsborg had been critically rejected, a geometric Viking fortress was surprisingly discovered on Zealand, named after the site, a so called Trelleborg fortress. This was followed by the search for more fortresses all over Scandinavia, a search that is still ongoing. Their ramp

Background and ObjectivesSpinocerebellar ataxias (SCAs) and other neurodegenerative cerebellar ataxias (N-SCAs) involve alterations in cerebellar structure and function, affecting motor control and sensorimotor integration but also cognitive functions such as visuospatial processing. The cerebellum is essential for sensorimotor functions, and it contributes to cognition. The study aims to assess s

Research on adolescent sexual orientation has expanded in recent decades, yet little is known about its associations with personality traits during this developmental period. This study examined personality dimensions, as measured by the Junior Temperament and Character Inventory, across adolescent sexual orientation groups (asexual, homosexual, heterosexual, bisexual) in a community-based sample

The cotton fabric consists of cellulose arranged in a complex structure with multiple levels of organization at different length scales. Understanding this structure and its interactions with water and oil is essential for developing efficient and environmentally friendly methods of cotton washing. In this study, the structure of raw cotton fabric cellulose and the effects of water and oil were ex

Background: Concizumab is an anti-tissue factor pathway inhibitor monoclonal antibody in development as a once-daily, subcutaneous prophylaxis for patients with haemophilia A or haemophilia B with or without inhibitors. We aimed to assess the efficacy and safety of concizumab in patients with haemophilia A or B without inhibitors. Here we report the results from the confirmatory analysis cutoff. M

Purpose: To evaluate inter- and intrarater reliability, of the Eating and Drinking Ability Classification System (EDACS) for children and adults with cerebral palsy (CP) in Sweden. Methods: Four speech and language pathologists rated EDACS from videos of 30 individuals with CP, 3 to 62 years, (mean 21 y, 10 m, SD 18 y, 6 m), six at each level of the Gross Motor Function Classification System (GMFC

Diffusion models were initially developed for text-to-image generation and are now being utilized to generate high quality synthetic images. Preceded by generative adversarial networks (GANs), diffusion models have shown impressive results using various evaluation metrics. However, commonly used metrics such as Frechet inception distance and inception score are not suitable for determining whether

OBJECTIVES: To compare patient reported outcomes from before surgery to 52 weeks after surgery between individuals undergoing arthroscopic partial meniscectomy for traumatic meniscal tears and those for degenerative meniscal tears.DESIGN: Comparative prospective cohort study.SETTING: Four public orthopaedic departments in the Region of Southern Denmark. Participants were recruited between 1 Februa