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While numerous antibody-antigen systems have been structurally characterized, studies of structurally analogous T-cell receptor MHC systems have lagged behind largely due to the lack of a general TCR expression system. Efforts to develop bacterial systems have resulted in low yields (< 0.5 mg/l) of active material which is prone to proteolysis and aggregation. Here we report a strategy to secrete

Only in Sweden, single-family houses account for approximately 30% of energy use in all buildings and a large part uses only electricity for heating. The potential for improvements on energy efficiency in these houses is large. This study theoretically investigates retrofitting of electrically heated Swedish single-family houses by using an air-source heat pump for both space heating and domestic

This paper describes a measurement of fiducial and differential cross sections of gluon-fusion Higgs boson production in the H → W W∗→ eνμν channel, using 20.3 fb−1 of proton-proton collision data. The data were produced at a centre-of-mass energy of s=8 TeV at the CERN Large Hadron Collider and recorded by the ATLAS detector in 2012. Cross sections are measured from the observed H→ W W∗→ eνμν sig

This qualitative case study aims at understanding when and how industrial designers, working in design consultancies, engage in activities that will influence material selection in the design process. While the extant literature presents material selection processes as a sequence of activities aimed at finding candidate materials, there is paucity of research on material criteria activities. Formu

Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical trials in melanoma; however, 50-60% of the patients have no clinical benefit. Here, we searched for predictive biomarkers to ACT in melanoma. Whole exome-and transcriptome sequencing and neoantigen prediction were applied to pre-treatment sample

B lymphocyte development is a complex biological process critically dependent on the transcription factor early B cell factor (EBF). To deepen understanding of the roles for EBF in this process, we have used Pearson correlation analysis to evaluate microarray data from a set of mouse B lymphoid cell lines representing different stages of development. Comparing the expression pattern of EBF to that

Tailored supercritical carbon dioxide (scCO(2)) extraction of alkyhesorcinols (ARs) from rye bran resulting in pre-purification of ARs already during extraction process. The pre-purification was achieved by splitting the extraction process in 2 steps.. In both steps, the CO2 pressure was set at 25 MPa with a flow rate of 10 g/min. The first step was carried out at 70 degrees C. 0.06% of ethanolic

Detailed mineral magnetic measurements were carried out on three varved lake-sediment sequences in Sweden, which extend to ca. 7000 BC. The comparison of the magnetic properties of the organic rich varved lake-sediments with their respective catchment materials indicates that the magnetic properties of the sediments are dominated by relatively high concentrations of single-domain magnetite magneto

Properties of polyelectrolyte gels in equilibrium with a reservoir of salt solution described within the primitive model have been investigated using Monte Carlo simulations. The polyelectrolyte gel was modeled as a charged defect-free three-dimensional network of diamondlike topology with explicit simple ions. The deswelling upon addition of salt was investigated for gels with different charge de

We have studied the stability of the dopaminergic phenotype in a conditionally immortalized human mesencephalic cell line, NIESC2.10. Even though MESC2.10 cells exhibit features of dopaminergic neurons in vitro, none of the cells expressed tyrosine hydroxylase (TH) after transplantation into a rat model of Parkinson's disease. We examined whether this is caused by cell death or loss of transmitter

he regional coastal evolution model Cascade was enhanced to better describe the transfer and storage of sediment. Focus was on the cross-shore exchange of material from the subaerial to the sub-aqueous portion of the beach and on shoal evolution at coastal inlets. Cross-shore material exchange now includes erosion due to wave impact and overwash, and barrier and dune build-up by wind. Cascade was

In todays knowledge economy the use of information and communcation technology (ICT) is ever increasing. The need for investment in ICT infrastructure is stressed from a range of policy makers. In this thesis, using the concept of virtual proximity, the question of how these ICTs can facilitate innovation for rurally located companies will be discussed. The thesis will be aimed at the plastic indu

Foreign invested SMEs have recently become increasingly interested in China. The enterprises are in this report categorized as second wave companies since they follow the footsteps of previous pioneers, of which mostly were larger companies. The ambitions of the SMEs are either to sell products on the ever expanding Chinese market or to utilize the potential of low cost production for global marke

The purpose of this essay is to examine how two nonfiction books for children in the category sexual education from Sweden portrays gender and sexuality. Norman Fairclough’s critical discourse analysis is the method of choice, where the nonfiction books are seen as part of a discourse in which language is not neutral. The analysis is based on Judith Butler’s theories on the heterosexual matrix and

Bytesrätten har utvecklats i samklang med den svenska bostadspolitiken. Under tidigt 1900-tal fanns det en stark liberal inställning till relationen mellan hyresgäster och hyresvärdar. I 1907 års nyttjanderättslag (1907:36), NyttjL, gällde grundläggande avtalsrättsliga principer. Hyresgäster fick enbart säga upp kontrakt om hyresvärden nekade dem överlåtelse av kontraktet utan skälig anledning. I The right to barter a rented apartment has developed in harmony with the Swedish housing policy. During the early twentieth century a strong liberal doctrine dominated the relationship between tenants and landlords. The usufruct law (nyttjanderättslagen) from 1907, was based on contractual principles. Contracts could be for as long as 25 years in the towns and tenants were only allowed to terminat

This essay is written in collaboration with the Environment Department in Malmö. The essay is a study in how the recycling of waste caused by visitors at major public events works. These events last for a shorter period of time and usually attract large numbers of visitors, thus large amounts of waste are produced during this short period. Previous investigations show that only a few major events

Syftet med denna studie var att se om man kan påverka individers upplevelser av en förhandling med hjälp av kunskap om Fisher & Shapiros (2005) fem kärnpunkter. Kärnpunkternas mål är att generera positiva känslor och bevara goda relationer i en förhandling. Deltagarna var med om ett experiment där hälften av deltagarna fick undervisning i kärnpunkterna och hälften inte. Därefter deltog samtligThe purpose of this study was to examine whether we could affect individual’s experiences of a negotiation by teaching them about Fisher & Shapiro’s five core concerns of negotiation (Fisher & Shapiro 2005). The core concerns aim to generate positive emotions and maintain good relationship within negotiations. The participants took part in an experiment in which half of them received educa