Filtyp
Over the last two decades the market for membrane technology in the food industry increased to a market volume of approx. € 50 million and is now the second largest industrial market for membranes after municipal water treatment in Germany. The key membrane technologies in the food industry are the pressure driven membrane processes; microfiltration, ultrafiltration, nanofiltration and reverse os
Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical trials in melanoma; however, 50-60% of the patients have no clinical benefit. Here, we searched for predictive biomarkers to ACT in melanoma. Whole exome-and transcriptome sequencing and neoantigen prediction were applied to pre-treatment sample
The HPV16 E5 open reading frame (ORF) is present on the majority of all alternatively spliced HPV16 mRNAs, but it is currently unknown how well it is translated into E5 protein. To identify HPV16 mRNAs that are efficiently translated into E5, we have generated cDNA plasmids expressing individual, alternatively spliced HPV16 mRNAs with the potential to produce E5. By replacing the E5 ORF with sLuc,
Five small dune fields were investigated in central Sweden in the field and by using LiDAR-based remote sensing. The chronology of the dunes was determined using optically stimulated luminescence (OSL) dating. Most of the OSL ages indicate dune formation close to the time of deglaciation in this area of Sweden (11-10 cal. ka BP) and later sand drift events appear to have been uncommon, suggesting
Identification of agricultural pest insects is an important aspect in insect research and agricultural monitoring. We have performed a methodological study of how spectroscopic techniques and wing-beat frequency analysis might provide relevant information. An optical system based on the combination of close-range remote sensing and reflectance spectroscopy was developed to study the optical charac
While numerous antibody-antigen systems have been structurally characterized, studies of structurally analogous T-cell receptor MHC systems have lagged behind largely due to the lack of a general TCR expression system. Efforts to develop bacterial systems have resulted in low yields (< 0.5 mg/l) of active material which is prone to proteolysis and aggregation. Here we report a strategy to secrete
Only in Sweden, single-family houses account for approximately 30% of energy use in all buildings and a large part uses only electricity for heating. The potential for improvements on energy efficiency in these houses is large. This study theoretically investigates retrofitting of electrically heated Swedish single-family houses by using an air-source heat pump for both space heating and domestic
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) has been clinically validated as a target for antimalarial drug discovery, as a triazolopyrimidine class inhibitor (DSM265) is currently undergoing clinical development. Here, we have identified new hydroxyazole scaffold-based PfDHODH inhibitors belonging to two different chemical series. The first series was designed by a scaffold hoppi
Based on a modified force balance model, new correlations were proposed for the prediction of vapor bubble departure radius in saturated and subcooled pool boiling under atmospheric pressure. To predict the departure radius, the wall temperature and contact angle are two important input parameters. Instead of the static contact angle, the present correlations use the dynamic advancing contact angl
In view of the grazing optimization theory, we examined the effects of different intensities of grazing by the enchytraeid Cognettia sphagnetorum (Vejdovsky) on microbial respiration and hyphal length in soil. In a feeding experiment we established that C. sphagnetorum feeds on the fungus Mortierella isabellina (Oudem) and that the worms disperse fungal propagules. Grazing of C. sphagnetorum with
Residual stresses induced by machining operations can be critical for the performance and lifetime of the machined components. Tis paper investigated the influence of cutting conditions, including the use of cutting fluid, cutting speed and tool flank wear, on the residual stresses in high speed turning of Inconel 718 alloy. X-ray diffraction measurements revealed characteristic residual stress di
This article investigates how donation behavior to charitable organizations and helping intentions toward begging European Union (EU)-migrants are related. This question was tested by analyzing survey responses from 1,050 participants sampled from the general Swedish population. Although the overall results suggested that donations to charitable organizations were positively related to helping int
As the formal work of the IWA Task Group on Benchmarking of Control Strategies for Wastewater treatment Plants (WWTPs) has come to an end, it is essential to continue to disseminate the intense research in this field that is still carried out. In 2013 and 2014, all authors of the IWA Scientific and Technical Report on benchmarking came together to provide their insights, highlighting areas where k
The mechanism of gallbladder contraction induced by infusion of hydrochloric acid (HCl) into the duodenum in dogs with chronic Jones gallbladder cannula, Thomas pancreatic fistula and gastric fistula was investigated. The results were as follows:1. Atropine, hexamethonium and diphenhydramine, but not phentolamine, propranolol, and naloxone decreased the gallbladder pressure elevated by duodenal ac
This Letter presents the first search for a heavy particle decaying into an e(+/-)mu(-/+) final state in root s = 7 TeV pp collisions at the LHC. The data were recorded by the ATLAS detector during 2010 and correspond to a total integrated luminosity of 35 pb(-1). No excess above the standard model background expectation is observed. Exclusions at 95% confidence level are placed on two representat
The moisture content of wood is commonly determined by measuring the electrical resistance between two electrodes inserted in the wood. However, problems using this method close to wood surfaces were reported in a previous study. In the present study, the effect of the distance to a surface and the specimen size on the measured electrical resistance was studied analytically as follows. The two ele
Simulations have been carried out by means of computational fluid dynamics for turbulent convective heat transfer in a cross-corrugated plate pattern heat exchanger unitary cell at a Reynolds number of 4930. Chen's high-Reynolds-number k-E model, the Reynolds stress model (RSM), Suga's low-Reynolds-number k-E model, and the V2F model were used. The predicted hydraulic and thermal behaviors using t
This pilot study applies a new 3D morphometric MR method to test the hypothesis that men with schizophrenia (vs. controls) have deviant facial shapes and landmark relations in cranio/facialibrain (CFB) regions. This constitutes Part 2 of paired articles in this issue of Psychiatry Research: Neuroimaging, in which Part 1 presents the new method in detail. MRI coordinates from CFB landmarks of 23 pa
Objectives: The purpose of this study was to design, validate, and optimize internally standardized real-time quantitative RT-PCR assays and to identify and avoid problems with assay reliability and examine the impact of an exogenous internal standard. Design and methods: The model system consisted of internally standardized quantitative real-time RT-PCR assays specific for PSA and hK2 mRNA based
