Filtyp
Background: Bone age assessment (BAA) is used in numerous pediatric clinical settings as well as in legal settings when entities need an estimate of chronological age (CA) when valid documents are lacking. The latter case presents itself as critical as the law is harsher for adults and granted rights along with imputability changes drastically if the individual is a minor. Traditional BAA methods
Summary: Background: Diabetes mellitus (DM) is a risk factor for peripheral arterial disease (PAD). Indications for open surgery in infrainguinal intermittent claudication (IC) are limited, and reports are lacking regarding outcomes in DM patients. Study aims were to compare short and long-term effects on major adverse cardiovascular events (MACE), acute myocardial infarction (AMI), stroke, major
Interleukin-15 (IL-15) is a cytokine that has been shown to expand CD8 T cell and natural killer (NK) cell populations, and therefore has potential for potentiating adoptive immune cell therapy for cancer. Previously, IL-15 has been shown to induce proliferation of CD8 memory T cells through activation of telomerase. Here, we investigated whether telomerase is also activated during the IL-15 media
There is widespread agreement on the many benefits citizens gain from recreational use of local green spaces such as urban woodlands, and the importance of involving users in the development of their everyday landscapes. Despite this, the impact of userparticipation on the quality of public green spaces has not been thoroughly studied. In this PhD thesis, resident participation in public urban woo
Background: Infants with congenital heart defects (CHD) are at risk for white matter brain injury. This novel rat pup model characterizes the systemic effects of intravasal cell-free hemoglobin and hyperoxia, hypothesizing that immature endogenous scavenging systems relate to increased vulnerability to conditions present during cardiopulmonary bypass (CPB).Methods: Plasma pharmacokinetics of cell-
Motivated by the pioneering activation-energy asymptotic analysis of strained laminar premixed flames in counterflow by Libby and his coworkers, a rate-ratio asymptotic analysis is carried out to elucidate the structure and predict the critical conditions of extinction of strained premixed methane flames. Steady, axisymmetric, laminar flow of two counterflowing streams: a reactive mixture stream a
Objectives: The primary objective was to investigate the utility of blood-basedbiomarkers of amyloid, tau, and neurodegeneration for (i) screening, (ii)enrichment, and (iii) tracking response to treatment in clinical trials of Alzheimer’sdisease.Methods: Longitudinal, participant-level data used in these studies was drawn fromthe Swedish BioFINDER study and the ADNI study. Participants were classi
Background: Surgical extraction of testicular spermatozoa is needed in men with nonobstructive azoospermia (NOA) who wish to become biological fathers. Based on available uncontrolled studies with unspecific patient selection, microdissection testicular sperm extraction (mTESE), having a sperm retrieval rate (SRR) of 50%, is considered the most efficient sperm retrieval procedure. However, no rand
BACKGROUND: We previously observed decreasing resection rates of non-metastatic gastric adenocarcinoma (GaC) in the US and some European countries. If and to what extent these trends affect the trends in overall survival (OS) of patients with non-metastatic GaC at the population level remain unclear. This large international population-based cohort study aimed to assess the impact of the previousl
BACKGROUND: During the past 4 decades, there has been a growing focus on preserving the fertility of patients with childhood cancer; however, no large studies have been conducted of live births across treatment decades during this period. Therefore, the authors estimated the potential birth deficit in female childhood cancer survivors and the probability of live births. METHODS: In total, 8886 wom
BACKGROUND: Individuals with multiple islet autoantibodies are at increased risk for clinical type 1 diabetes and may proceed gradually from stage to stage complicating the recruitment to secondary prevention studies. We evaluated multiple islet autoantibody positive subjects before randomisation for a clinical trial 1 month apart for beta-cell function, glucose metabolism and continuous glucose m
BACKGROUND: Orthopaedic surgeons aim for mechanical alignment when performing total knee arthroplasty (TKA) as malalignment is associated with loosening. Loosening may be predicted by migration as measured with radiostereometric analysis (RSA), but previous RSA studies on postoperative alignment have shown contradictory results and have been limited to cemented implants and small numbers of patien
Background: Hip and groin problems are just as common in ice hockey as they are in soccer. The 5-second squeeze test (5SST) is a valid indicator of hip- and groin-related sporting function (self-reported function) in soccer and is suggested to be interpreted according to a “traffic light” approach in guiding the early identification and management of affected players. It is currently unknown how t
Quinoa stalks were used as a source of hemicellulose for XOs production and further as prebiotic source for probiotic bacteria. Three methods for extraction of hemicellulose were used, of which alkaline extraction (NaOH [0.5 M]) was the optimum method. This methodology allowed the establishment of a sequential extraction platform, including saponins obtention via PHWE, hemicellulose via alkaline e
BACKGROUND: In contrast with macroorganisms, that show well-documented biogeographical patterns in distribution associated with local adaptation of physiology, behavior and life history, strong biogeographical patterns have not been found for microorganisms, raising questions about what determines their biogeography. Thus far, large-scale biogeographical studies have focused on free-living microbe
Soot, or black carbon (BC), aerosol is a major climate forcer with severe health effects. The impacts depend strongly on particle number concentration, size and mixing state. This work reports on two field campaigns at nearby urban and rural sites, 65gkm apart, in southern Sweden during late summer 2018. BC was measured using a single-particle soot photometer (SP2) and Aethalometers (AE33). Differ
Background: The first interim analysis of the phase III, randomized, double-blind, placebo-controlled, multinational TITAN study demonstrated improved overall survival (OS) and radiographic progression-free survival (rPFS) with apalutamide added to ongoing androgen deprivation therapy (ADT) in patients with metastatic castration-sensitive prostate cancer. The final analysis confirmed improvement i
BACKGROUND: Qigong includes training for body and mind, one method is Zhineng Qigong. Scientific literature on qigong for chronic low back pain (LBP) is sparse. This study aimed to investigate feasibility including evaluation of a Zhineng Qigong intervention for pain and other lumbar spine-related symptoms, disability, and health-related quality of life in patients with chronic LBP and/or leg pain
I samband med lantmäteriförrättningar där ersättningsbeloppet behöver framtas med hjälp av de värderingsmedel som Lantmäteriet eller utsedd värderingsman har att tillgå är det ytterst viktigt att ingångsparametrarna är korrekta. Då fastighetsregleringar där vinstfördelning blir aktuellt och där genomsnittsvärdeprincipen aktualiseras är det råtomtmarksvärdet som eftersöks. I värderingsutlåtandet reDuring land surveying operations, the amount of compensation needs to be calculated using the valuation means taken by the land surveyor or appointed appraiser. For this reason, it is important that input parameters are correct. As profit distribution is a pressing concern in relation to real estate regulations, raw land value is sought after. In this case, the responsible land surveyor reports fo
Purpose: This investigation was designed to examine the effects of self-monitored training combined with the use of delayed auditory feedback (DAF), on the accuracy of articulation in acquired apraxia of speech (AOS). Background: The increased number of stroke survivors leads to higher societal costs when it comes to e.g., rehabilitation. Speech and language deficits post stroke can be diminished
