Filtyp
OBJECTIVES: Preeclampsia (PE) is a common pregnancy-related disorder associated with cardiovascular long-term disease. Eighty percent are late-onset PE, occurring after 34 gestational weeks, and can present with severe symptoms. Magnitude and reversibility rate of maternal cardiovascular changes after severe late-onset PE have not been characterized. This study therefore evaluated longitudinal dyn
Mobility-as-a-Service (MaaS) has been argued as part of the solution to prevalent transport problems. However, progress from pilots to large-scale implementation has hitherto been slow. The aim of the research reported in this paper was to empirically and in-depth investigate how, and to what extent, different factors affect the development and implementation of MaaS. A framework was developed, wi
This study investigated how a history of menopausal hormone therapy (MHT) impacts clinical outcomes overall and in different subgroups of breast cancer patients. The study included 814 primary breast cancer patients aged ≥50 years in Sweden (2002–2012) with follow-up until 2016. Associations between patient- and tumor characteristics, recurrences, and overall survival were analyzed in relation to
To date, approximately 15% of all couples worldwide suffer from infertility. The management include controlledovarian hyper-stimulation of the women with follicle-stimulating hormone (FSH) and semen analysis of the men,prior to in vitro fertilization (IVF) and transfer of the fertilized embryo to the uterine cavity. Approximately 250 000IVF cycles are performed worldwide each year, and as a result
Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissues. Here, we screened the expression of homeobox genes in mammary stem cells to establish their role in stem cells transformation in breast cancer. Met
Transplantation of neural tissue from other species has the potential to improve function in patients with neurodegenerative disorders. We investigated the functional effects of embryonic porcine dopaminergic neurons transplanted in a rat model of Parkinson's disease and the immune responses to the grafts in immunosuppressed and nonimmunosuppressed hosts. Twenty-three rats with unilateral 6-hydrox
This thesis contains four independent research papers, which investigate the causal relations between several aspects of health and economic outcomes at different stages of the life course. The first paper investigates the causal effects of maternal deprivation and maltreatment during various periods of childhood on adolescent health and human capital. Using hospital data and information onninth y
Background: Delayed reconstruction of transection or laceration injuries of peripheral nerves is inflicted by a reduced regeneration capacity. Diabetic conditions, more frequently encountered in clinical practice, are known to further impair regeneration in peripheral nerves. Chitosan nerve guides (CNGs) have recently been introduced as a new generation of medical devices for immediate peripheral
OBJECTIVE: To study the usefulness of (18)F-AV-1451 PET in patients with corticobasal syndrome (CBS).METHODS: We recruited 8 patients with CBS, 17 controls, 31 patients with Alzheimer disease (AD), and 11 patients with progressive supranuclear palsy (PSP) from the Swedish BioFINDER study. All patients underwent clinical assessment, (18)F-AV-1451 PET, MRI, and quantification of β-amyloid pathology.
Background: New or increased impairments may develop several decades after an acute poliomyelitis infection. These new symptoms, commonly referred to as late effects of polio (LEoP), are characterised by muscular weakness and fatigue, generalised fatigue, pain at rest or during activities and cold intolerance. Growing older with LEoP may lead to increased activity limitations and participation res
Background: Swallowing dysfunction is an increasingly recognized problem in patients with dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), which can result in aspiration pneumonia and death. Few studies have examined potential ways of improving swallowing function in this fragile patient group. The aim of this study was to evaluate swallowing dysfunction and carbonated liqui
We examined aerobic and anaerobic microbial carbon dioxide (C02) and methane (CH4) exchange in peat samples representing different profiles at natural, mined, mined-abandoned, and restored northern peatlands and characterized the nutrient and substrate chemistry and microbial biomass of these soils. Mining and abandonment led to reduced nutrient and substrate availability and occasionally drier co
The rates of positive tuberculin skin test (TST) reactions and BCG scarring after BCG vaccination vary between studies and populations. Tuberculin reactivity and BCG scarring may be related to better child survival in low-income countries. We therefore studied determinants for TST reaction and scarring in Guinea-Bissau. In a cohort of children born in suburban Bissau from March 2000 to July 2002,
Background: Despite the fact that heart failure and chronic obstructive pulmonary disease (COPD) often exist together and have serious clinical and economic implications, they have mostly been studied separately. Our aim was to study prevalence of coexisting heart failure and COPD in a Swedish population. A further goal was to describe levels of other comorbidity and investigate where the patients
The Campanian marine strata from Åsen, north east part of the Kristianstad Basin (southern Sweden) contain a most diverse vertebrate and invertebrate marine fossil assemblages. A diverse fossil fauna was collected from Campanian deposits from a ca. 4.15m thick section during June-August 2010-2012. The succession is divided into two zones, the latest early Campanian Belemnellocamax mammilatus Zone
Vad är det som gör att man begår ett brott? Vad är det för slags person som begår ett brott? Kriminella personer har alltid varit ett intresse för forskning och allmänheten. Det finns förutfattade meningar om hur en kriminell person ser ut eller beter sig. Samtidigt finns det en lika tydlig bild av hur en kvinna eller man ska se ut eller bete sig. En kriminell kvinna går emot alla förväntningar meWhat does it take for a person to commit a crime? What kind of person commits a crime? Offenders have always been interesting for both research and the society. There is a preconceived notion on how an offender should look or act like. At the same time, being a woman or a man comes with equal preconceptions. However, a female offender goes against all expectations of how an offender should act and
Northern peatlands have accumulated carbon for thousands of years and currently hold around one third of all soil carbon on earth. Large uncertainties are associated with predictions of how northern peatlands will react to climate change. This is because the cold, wet and anaerobic conditions lead to two opposing forces from a radiative forcing perspective – CO2 sequestration from photosynthesis b
It is becoming more and more common to exercise regularly, and with this new fitness trend follows more exercise applications to our smartphones. Applications aiming to help us exercise by structuring and logging our training. The user experience for these applications can be a little bit dull, since most of the applications depend on the user following instructions and entering input of the resul
Lekmän som domare i rättssalen är ett gammalt fenomen på många håll i världen. Europa har en lång historia av personer utan juridisk utbildning som är med och dömer. I Sverige kallas sådana domare för nämndemän och dömer idag tillsammans med juridiskt utbildade domare i tingsrätt, hovrätt, förvaltningsrätt och kammarrätt. På senare år har dessa politiskt tillsatta nämndemän och deras system varit Lay judges is an old phenomenon in many parts of the world. There is a long history of people without a legal education that have been participating in court as judges in Europe. In Sweden, such judges are called nämndemän and they work together with legally trained judges in the low and high courts of Sweden. In recent years these politically appointed nämndemän and their system have been subject
En allmän lojalitetsprincip anses gälla i obligationsrätten men sättet som denna princip kommit att få fäste i den svenska rättsordningen avviker från hur rätten vanligtvis utvecklas. Principen har inget enhetligt eller fastställt innehåll och det är omdebatterat hur omfattande principen är och hur den kommer till uttryck i svensk rätt. Uppsatsens övergripande syfte är att försöka utreda hur lojalA general principle of good faith is considered to be applicable in Swedish contract law, however, the means in which this principle has taken hold in Swedish law deviates from the customary development of the law. The principle has no unanimous or clearly determined definition and it is debated how extensive the principle is and how it is expressed in Swedish law. The overarching purpose of this
