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AimsWe recently identified a metabolic signature of three amino acids (tyrosine, phenylalanine, and isoleucine) that strongly predicts diabetes development. As novel modifiable targets for intervention are needed to meet the expected increase of cardiovascular disease (CVD) caused by the diabetes epidemic, we investigated whether this diabetes-predictive amino acid score (DM-AA score) predicts dev
Objective. To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression. Methods. We measured the mechanical axis from long limb radiographs from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI) to define limbs with valgus malalignment (mechanical axis of >= 1.1 degrees valgus) and examined the effect of valgus alignment versus
F-18-flutemetamol is a positron emission tomography (PET) tracer for in vivo amyloid imaging. The ability to classify amyloid scans in a binary manner as 'normal' versus 'Alzheimer-like', is of high clinical relevance. We evaluated whether a supervised machine learning technique, support vector machines (SVM), can replicate the assignments made by visual readers blind to the clinical diagnosis, wh
Aims To compare the effect of initial monotherapy with either bisoprolot or enalapril, followed by their combination, on mortality and hospitalization in patients with mild-to-moderate CHF. Methods and results One thousand and ten patients with mild-to-moderate CHF and left ventricular ejection fraction <= 35%, without ACE-inhibitor, beta-blocker, or angiotensin-receptor-blocker therapy were rando
Popular Abstract in Swedish Avhandlingen består av fyra kapitel som behandlar olika aspekter av internationell handel och dess effekter på konkurrens och produktivitet. Särskilt behandlas effekterna av EU:s expansion och fördjupade integration. Första kapitlet använder den så kallade gravitationsmodellen för att analysera hur integrationsprocessen av de Central- och Östeuropeiska länderna i EU haThis thesis consists of four papers on trade, competition and productivity with particular emphasis on the effects of various aspects of the deepening and widening of the European Union. The first paper Trade Creation, Diversion and Displacement of the EU Enlargement Process provides an assessment of the effects of the EU enlargement process on trade. A new method of estimating the gravity model
In this master´s thesis I seek to explore the concept of restorative justice, an ideological approach to justice which aims to repair the harm caused by crime through means of communication, cooperation, participation and restoration. By involving all parties affected by crime, restorative justice seeks to address crime through empowering victims, increasing community cohesion and making offenders
Improvements in Internet technology, development of multimedia applications, protocols and improvement in user devices have led to the popularity of multimedia applications, among which video streaming applications are most popular. Streaming video services are sensitive to network conditions, thus making Quality of Experience (QoE) of end users sensitive to network conditions. QoE is affected by
Siemens Industrial Turbomachinery has developed dynamic gas turbine models to compute performance parameters such as temperature, pressure, mass flow and power during transients. Results from the current dynamic model correspond to measured data except for gas channel temperatures that change too fast during transients. The measurement of gas channel temperature is also a source of error due to th
A large and rapidly growing population in Kenya together with increasing demands put heavy pressure on the country’s resources. Primary to produce enough food but also to meet other needs such as access to timber and firewood. A large part of the population relies on yields from their own farming for their survival. The farms are generally small and the needs many which makes it important to get o
För att en person ska kunna straffas för våldtäkt enligt svensk rätt krävs det att denne har haft uppsåt till gärningen. Det innebär att personen måste ha varit medveten om alla de omständigheter som medfört att gärningen är att betrakta som en våldtäkt, exempelvis att den utsatte sov eller tvingades till de sexuella handlingarna. Detta krav på uppsåt har i ett flertal fall, där den tilltalade fri
In today’s competitive vehicle industry, fuel efficiency and weight plays a crucial role in performance and to maintain an attractive market position. The increasing technological development is opening new possibilities to design components with lighter materials. All components on Scania buses are favorably designed with as low weight as possible since the measured load on the back axis determin
This bachelor project provides an analysis of the regional, organizational arena of Denmark and takes point of departure in the structural reform of 2007, which changed the Danish political landscape radically. The result of the reform was that the old municipalities and regions were enlarged and the power relation was changed. The new physical form made the municipalities far more influential, an
Title: Frenemies in Business: A Case Study on the Phenomenon of Coopetition Research Question: What are drivers and challenges behind coopetition, as well as possible outcomes of the relationship? Keywords: Coopetition, Cooperation, Competition, Coopetitive Relationship, Competing Companies, Coopetitors, Coopetition Process, Drivers, Challenges, Possible Positive Outcomes, Possible Negative Out
After the General Court’s (GC) decision in case T-472/13 H. Lundbeck A/S and Lundbeck Ltd v Commission it seems the concept of potential competition in the context of so-called ‘pay-for-delay’ agreements, or reverse patent settlements, might have been altered; that the bar in order for an undertaking to qualify as a potential competitor might have been lowered. This thesis aims to examine whether
I Sverige finns en åldersgräns på 18 år för att ingå äktenskap men det finns ändå barn under 18 år i Sverige som är gifta. De gifta barnen har ingått barnäktenskap utomlands. Äktenskapen har erkänts som giltiga i Sverige om makarna saknade anknytning till Sverige när äktenskapen ingicks. Diskussioner har förts om att regleringen av erkännande av utländska barnäktenskap måste ändras för att skyddetThe age limit for getting married in Sweden is 18 years. Yet there are children under the age of 18 in Sweden who are married. The children have gotten married abroad. The marriages have been recognized as valid in Sweden if the spouses had no connection to Sweden when the marriages were entered. Discussions have been held about that the regulation of recognition of foreign child marriages needs t
The technology has advanced but the vehicle industry has not evolved at the same pace. Mechanical constructions with a steering wheel are still being used to control the steering of cars. The mechanical construction makes it harder to implement autonomous features, it adds weight and takes up space. It is commonly known that the steering wheel has been along since the early days of the car but is
Undersökning av näthinneceller odlade på ljuskänsliga nanotrådar Människans sinnen bombarderas ständigt med nya intryck. En stor del av dessa förmedlas via vår syn. Ljus kommer in i ögat och absorberas av ljuskänsliga fotopigment som finns i de yttre segmenten av näthinnans fotoreceptorer. Näthinnan är uppbyggd av flera olika skikt och av flera olika celltyper, både nervceller och stödjande gliacWorldwide, millions of people suffer from retinal degenerative diseases leading to cell death of light absorbing photoreceptors. This results in vision impairment and, in many cases, eventually blindness. A possible solution for patients gone legally blind due to retinal degeneration, is the use of retinal implants. The best performing retinal implants of today, regarding vision acuity, still give
Inom hjärnforskning används cellkultursbaserade modeller i stor utsträckning som en experimentell plattform, både i grundforskning och läkemedelsupptäckt. Dessa modeller är användbara vid tidig utvärdering av en potentiell läkemedelskandidat. Eftersom nya läkemedel tar extremt mycket tid och pengar att utveckla, vore en så exakt modell som möjligt att föredra.1 En viktig fråga i upptäckt och utvA low success rate of drug candidates in clinical trials, and especially in brain research, motivates development of better screening models. Hence, in neuroscience and many other fields of Life Science, development of more physiological relevant experimental cell-based models is motivated. It’s believed that more in vivo-like models will give a better outcome in drug discovery- and development. H
CK2 is an extremely pleiotropic Ser/Thr protein kinase, responsible for the generation of a large proportion of the human phosphoproteome and implicated in a wide variety of biological functions. CK2 plays a global role as an anti-apoptotic agent, a property which is believed to partially account for the addiction of many cancer cells to high CK2 levels. To gain information about the CK2 targets w
Long term effects after peptic ulcer surgery still exert an influence on some patient groups. Partial gastrectomy increases the risk of gastric carcinoma more than 20 years after surgery and enterogastric reflux is regarded as the main ethiological factor. Partial gastrectomy also gives increased risk of other malignancies as well as smoking related disease. Parietal cell vagotomy (PCV) is conside
