Filtyp
Bioplastics are a promising alternative for petroleum-based plastics that today is on high demand in our contemporary lifestyles. They are made from biopolymers such as polyhydroxyalkanoates (PHAs). Producing biopolymers from waste material feedstock using microbes increases profitability and environmental benefits as well as sustainability for biorefineries. Saccharomyces cerevisiae is a robust m
Megalencephalic leukoencephalopathy with subcortical cysts (MLC), is a congenital leukodystrophy with childhood onset. It is an extremely rare genetic disorder of the brain that affects less than 1 per 1,000,000 live births. Patients typically present macrocephaly during early childhood and later develop symptoms like decreased motor and cognitive functions, and epileptic seizures, all of which us
The exact workings of amelogenin (AMG) as a key-regulator in the formation of enamel is still to be determined. It has been observed however, that AMG promotes tissue-regrowth and has promotive effect on e.g., osteoblastic cells and could therefore be of interest for medical applications. This project aimed to utilize AMG’s self-assembly properties to fabricate a protein-based biomaterial for cult
The task of specifying a brake system for a vehicle is without doubt one of the most crucial decisions a design manager must undertake in the development process of a vehicle. Improved vehicle aerodynamics, higher loads, more horsepower and increased road safety all create the need for more effective brake systems. The most dominant of these is the disc brake system, due to the absence of fade and
Intrinsic permeability of water in beefburgers made of different meat raw materials cooked at 50 degrees C, 60 degrees C, 70 degrees C and 80 'C was measured using an air-driven pressure cell, and it was found to be in the range of 6.8 x 10(-18) m(2) to 1.6 x 10(-16) m(2) for the temperature ranging from 50 degrees C to 80 degrees C. The highest permeability value was found in beefburgers prepared
A farm systems mass-balance calculation model, FARMFLOW, was applied to a case study comparing organic and conventional management of a Swedish experimental dairy farm, Ojebyn. Parameterisation of the model is implemented using detailed field data from the Ojebyn farm where the two management systems have been run parallel for more than 11 years. Simulations were made to compare the stocks, flows
Severe hypoglycemia was induced by insulin in lightly anaesthetized (70°o N2O) and artificially ventilated rats. Brain tissue was frozen in situ after spontaneous EEG potentials had disappeared for 5. 10. 15 or 30 min and cerebral cortex concentrations of labile organic phosphates, glycolytic metabolites, ammonia and amino acids were determined. In other experiments, recovery was induced by glucos
The aim of this study was to evaluate some bioassays that are different in principle: cell counting, colony forming assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT), sulforhodamine B (SRB), crystal violet, and alamarBlue, with respect to their ability to measure cisplatin-induced cell death of in vitro-cultivated squamous cell carcinoma of the head and neck (SCCHN). Cispl
The most important issue in this dissertation will be a discussion concerning metal age flint use in Scania. Since flint tools from the Bronze and Iron Ages and Medieval times have rarely been examined, there are few general guidelines in typology or morphology. It is quite clear that conversions of existing Stone Age typological schemes are unsuitable when one intends to study the often simple an
OBJECTIVE: To determine the diagnostic value of metaiodobenzylguanidine (MIBG) scintigraphy compared with computed tomography (CT) for the localization of phaeochromocytomas in clinical practice. DESIGN: Retrospective comparison between MIBG scintigrams and CT for localization of phaeochromocytomas in all patients successively examined with MIBG scintigraphy in Malmo from 1984 until January 1997.
The spectroscopic properties of spirilloxanthin in an nhexane solution and bound to the core light-harvesting LH1) complex of Rhodospirillum rubrum were studied by near infrared ultrafast transient absorption spectroscopy. Global analysis of the kinetic traces measured after excitation of spirilloxanthin to the S2 (1Bu +) state enabled us to estimate the species-associated difference spectra that
A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) in 2001. The assessment included an overview of the capacity for radiotherapy in terms of infrastructure of cancer care and an estimation of the costs of radiotherapy in Sweden. A postal questionnaire distributed to all 16 centres of radiotherapy in Sweden showed th
For the period 1420-1960 we contrasted fire events reconstructed at 14 sites distributed over a 50 km x 50 km area in the central part of the Komi Republic (European Russia) with a set of tree-ring width chronologies of Scots pine (Pinus sylvestris L.), developed for the same area. Our aim was to infer common climatic information contained in treering variables and independently dated fire events
ydrophobically modified polymers (HM-P) typically behave as thickeners in a wide range of systems. The thickening effect in an aqueous solution of this kind of polymer depends on intermolecular hydrophobic associations and also on chain entanglements if the polymer concentration is significantly above the overlap concentration. In the present investigation a rather short end-capped polymer has bee
The sensitivity of the rat submaxillary gland was examined 3-4 weeks after either parasympathetic decentralization or sympathetic decentralization or denervation. The threshold doses for secretion of saliva of parasympathomimetic (methacholine) and sympathomimetic (noradrenaline, adrenaline, phenylephrine and isoprenaline) drugs were estimated and the amount of saliva secreted in response to supra
Context: T-3 action in neurons is essential for brain development. Recent evidence indicates that monocarboxylate transporter 8 (MCT8) is important for neuronal T-3 uptake. Hemizygous mutations have been identified in the X-linked MCT8 gene in boys with severe psychomotor retardation and elevated serum T-3 levels. Objective: The objective of this study was to determine the functional consequences
The presence of polyamines in living cells is crucial for survival. Due to their high net charge at physiological pH, polyamines effectively charge neutralize the phosphodiester backbone of DNA in an interaction that also may protect the DNA from external damage. We here present a study illustrating the influence of spermidine and spermine on the platination reactions of the model oligonucleotides
In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GLP)-1. However, the role of glucagon receptor signaling for the regulation of islet function and insulin sensitivity is unknown. We therefore explored P-cell function and insulin sensitivity in Gcgr(-/
Insulin sensitivity and secretion are related in a curvilinear inverse asymptotic function. However, the signaling factors mediating this relation are not known. In this study, we explored whether circulating glucose, lipids or two adipocyte-derived hormones, leptin and adiponectin, are related to the curvilinear function between insulin sensitivity and secretion in subjects with normal glucose to
Aim: To study the influence of specific factors and events during pregnancy and the perinatal period on the risk of children developing inflammatory bowel disease. Methods: Population-based national register study. Linkage between the Swedish Medical Birth Register and the Swedish Hospital Discharge Register during the period 1987 to 2000 identified 455 singleton infants who later developed inflam
