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Introduction: Alcohol use disorder (AUD) has been identified as a strong risk factor for suicide attempt. However, few studies have considered protective factors that may moderate this association, such as resilience. Methods: We used longitudinal nationwide Swedish data of 903,333 males born 1960–1980 and 48,285 males born 1949–1951. We performed Cox proportional hazards models to test the role o
The use of Geographical Information Systems (GIS) within the society as well as in academic work has increased rapidly over the last decades. This also means that Geomatics has started to create problems in both academic and non-academic worlds. Firstly because it bridges borders that have been in place for a long time and secondly because Geomatics, or rather the basic concepts of Geomatics, is i
Hematopoietic stem cells (HSC) give rise to all types of blood lineages, including red blood cells (RBC). Hematopoietic stem/progenitor cells (HSPC) are known to be functionally diverse in terms of their self-renewal potential and lineage output. Consequently, investigation of molecular heterogeneity in the differentiation potential of HSPC is vital to identify novel regulators that affect generat
Climate warming has substantially advanced the timing of spring leaf-out of woody species at middle and high latitudes, albeit with large differences. Insights in the spatial variation of this climate warming response may therefore help to constrain future trends in leaf-out and its impact on energy, water and carbon balances at global scales. In this study, we used in situ phenology observations
Life’s Essential 8 (LE8) is a score that includes modifiable risk factors for cardiovascular disease. Four health behaviors (diet, physical activity, nicotine exposure and sleep health) and four health factors (non-HDL cholesterol, blood glucose, blood pressure and body mass index) are included. These modifiable risk factors promote inflammation, and inflammation is one of the biological mechanism
Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor condition for multiple myeloma (MM). We hypothesized that analyzing haplotypes might be more useful than analyzing individual SNPs, as it could identify functional chromosomal units
Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow-up exist. However, not all recommendations are strictly evidence-based. To evaluate consensus on the treatment and follow-up of patients with acromegaly i
BACKGROUND: The European registry for minimally invasive pancreatic surgery (E-MIPS) collects data on laparoscopic and robotic MIPS in low- and high-volume centers across Europe.METHODS: Analysis of the first year (2019) of the E-MIPS registry, including minimally invasive distal pancreatectomy (MIDP) and minimally invasive pancreatoduodenectomy (MIPD). Primary outcome was 90-day mortality.RESULTS
Major political events become a dominant topic of the discussions in the countries involved, and various actors, often other than political parties, take a stance towards them. The withdrawal of the UK from the European Union as a result of the 2016 UK referendum was one of those, and a quite polarised atmosphere from supporters of both sides was observed in the UK and the rest of Europe since the
PURPOSE: We studied the relative contributions of total peripheral resistance (TPR), stroke volume (SV) and heart rate (HR) to low blood pressure in classical orthostatic hypotension (cOH) on group and individual levels.METHODS: We retrospectively analyzed tilt test records from cOH patients and age/sex-matched controls. We quantified relative effects of HR, SV and TPR on mean arterial pressure (M
Objective: As a result of conflicting, inadequate or controversial data in the literature, several issues concerning the management of patients with abdominal aortic aneurysms (AAAs) remain unanswered. The aim of this international, expert-based Delphi consensus document was to provide some guidance for clinicians on these controversial topics. Methods: A three-round Delphi consensus document was
Bacterial arylmalonate decarboxylase (AMDase) and evolved variants have become a valuable tool with which to access both enantiomers of a broad range of chiral arylaliphatic acids with high optical purity. Yet, the molecular principles responsible for the substrate scope, activity, and selectivity of this enzyme are only poorly understood to date, greatly hampering the predictability and design of
Knock detection is critical for maintaining engine performance and preventing damage in spark-ignition engines. This study explores the use of ion current and knock indicators derived from a vibration sensor ((Formula presented.)) and ion current ((Formula presented.)) to improve knock detection accuracy. Traditional threshold-based methods rely on (Formula presented.), but they are susceptible t
Skin barrier damage and subsequent development of harmful microbiota contribute to conditions such as wound infections, atopic dermatitis and chronic wounds, which impact millions of people globally and pose a significant economic burden on healthcare systems. Established microbial sampling methods, such as swabs and tissue biopsies, provide limited information on the spatial distribution of bacte
Evidence shows psychological factors (e.g. stress) are linked to immunity, yet there is a lack of research investigating the complex interactions between psychological factors and immune function. Network analysis is useful to investigate complex interrelations between relevant health-related variables. This study applied network analyses to examine associations between psychological protective fa
Background: Recent studies indicate the need to examine how the gut microbiota–brain axis is implicated in pain, sensory reactivity and gastro-intestinal symptoms in autism spectrum disorder (ASD), but no scale exists that assesses all these constructs simultaneously. Methods: We created a pool of 100 items based on the real-world experience of autistic people, and a multidisciplinary team and sta
Objective: The primary objective of this study was to determine the association between longitudinal continuity of care (CoC) in Swedish primary care (PC) and emergency services (ES) utilisation.Study design: A cross-sectional analysis of longitudinal population data. Setting. PC centres, out-of-hours PC facilities and emergency departments (EDs) in Blekinge County in southern Sweden. Subjects: Pe
The sense of smell is a central sensory modality of most terrestrial species. However, our knowledge of olfaction is based on vertebrates and insects. In contrast, little is known about the chemosensory world of spiders and nothing about how they perform olfaction despite their important ecological role. The orb-weaving spider Argiope bruennichi lends itself to an in-depth study on olfaction as it
Background: The existence of a “minority tax,” defined as the burden of extra responsibilities placed on minorities relative to non-minorities of the same position, has been documented across various fields, including and beyond medicine. This study sought to quantify the types and extent of the minority tax faced by minority orthopaedic surgeons, as well as evaluate the degree to which this work
Purpose: The aim of this study was to evaluate bony fusion with Low Dose CT (LDCT) over time following posterior scoliosis surgery in an all screw construct in patients with AIS with special focus on whether the spinal fusion process continue to develop beyond 2 years after scoliosis surgery and to evaluate if LDCT is an adequate radiological method to assess fusion maturation. Methods: Twenty fiv
