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Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. The research presented in this thesis has focused on elucidating a possible involvement of the human protein alpha-1-microglobulin in the defence against pathological oxidation.
The potential of Fe-V-oxide catalysts for use in methanol oxidation is explored. Our results show that although FeVO4 is active and selective for formaldehyde formation, it is not completely stable towards volatilization under reaction conditions. Attempts to stabilize Fe-V-oxide were made using titania, alumina and silica supports. However, we observe that although some stabilization is achieved
The purpose of this study was to examine how young people who have chosen not to drink alcohol experience themselves and their surroundings. The aim was to find out what role temperance plays in their perceived identity. I also wanted to find out how they experienced the views of them, temperance and the temperance movement in their surroundings. Finally, I was interested in the question about alc
Marine pollution is an increasingly serious environmental problem. Close to half of the total marine pollution comes from vessels and the pollutant that is the most obvious is oil. Fortunately, this problem has been recognized almost all over the world. Vessel-source oil pollution has attracted large numbers of international legislation, as well as national. As we will see in this paper, it often
Objectives: SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss-of-function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes. Here we describe a novel dominant variant in SLC4A4 in patients wit
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a multifactorial disorder involving gut-brain axis dysregulation, altered barrier integrity, microbial imbalance, and stress-related mechanisms, with limited nutritional strategies targeting these pathways. Tannin-rich extracts may exert barrier-protective, microbiota-modulating, and stress-related effects. In a prospective before-after pilo
Episodic memories are leveraged to predict upcoming input. Latent Cause Theory (Gershman et al., 2017) predicts that after moderate prediction errors, existing memories will be updated by integrating new information, while after large prediction errors, a new latent cause is inferred, and the unpredicted event is encoded as a separate trace. To date, no study has directly compared memory updating
Serglycin (SRGN) has been found overexpressed and secreted in glioblastoma (GBM), associated with tumorigenic signaling and poor prognosis. In this study, we aimed to elucidate the involvement of SRGN in the unfolded protein response (UPR), an oncogenic signaling pathway implicated in protein recycling and cell fate. Herein, we developed stably transduced LN-18shSCR GBM cells, expressing high leve
Hereditary spinocerebellar degenerations (SCDs) is an umbrella term that covers a group of monogenic conditions that share common pathogenic mechanisms and include hereditary spastic paraplegia (HSP), cerebellar ataxia, and spinocerebellar ataxia. They are often complicated with axonal neuropathy and/or intellectual impairment and overlap with many neurological conditions, including neurodevelopme
The main purpose with this Master's thesis has been to through a case study investigate and analyze the music library activity at the Public Library in Lund, in order to find out according to which ideas and principals this activity is run by. It also discusses how you at the music department handle your task as intermediary of music and how well this coincides with the users expectations. To
Abuse of alcohol is one of the biggest problems that society faces today. There are between three and four hundred thousand abusers in Sweden. In addition there are about three hundred thousand over consumers. The government bill proposed in 1977 gave the labour market most of the responsibility to solve the problem. They thought a meaningful job and a spirit of community were the most important f
Denna studie har till syfte att undersöka hur rytmiken kan berika den kyrkliga verksamheten samt att kartlägga hur rytmikverksamheterna ser ut i fyra olika församlingar i Sverige. I teorikapitlet presenteras tidigare forskning och litteratur om Svenska Kyrkan som institution, musikens och dansens roll i kyrkan, rytmik, handlingsutrymme, samt Vygotskijs teorier om delaktighetens betydelse för barnsTitle: How can eurhythmics enrich the activities of Church of Sweden? A qualitative study of four pedagogues experiences, reflections and visions of Eurhythmics in the Church of Sweden. The purpose of this essay is to investigate how eurhythmics can enrich the activities in the work of the Church of Sweden and to study the eurhythmics activities in four different church communities. In the theory
Att undersöka stjärnor i infrarött är en relativt ny företeelse till skillnad från optisk astronomi (dvs. synligt ljus). Det var först på 60-talet med teleskopet Stratoscope II som man lyckades få spektra från stjärnor i infrarött (våglängder på runt 3 m), och upptäckte förekomsten av vatten i kalla röda jättar. Den bakomliggade problematiken till varför modern infraröd astronomi är så ungt är våThe advent of infrared astronomy, unlike optical astronomy that was developed over centuries, was delayed until the space age due to our own atmosphere acting as an efficient shield towards this radiation. With a lot of molecules (including water) emitting in the infrared region, it was first in the late 1990s that water no longer was deemed special and was observed in many cooler (K-M) giant star
Quantication of cardiovascular flow and blood volumes are useful tools in diagnosing cardiovascular disease such as congenital heart defects and different kinds of valve leakage. Medical imaging techniques enables non-invasive analysis of anatomy and physiology. In order to perform flow quantification from medical image sequences, the boundaries of the vessels of interest are usually delineated ma
The aim of this study was to highlight how women’s shelters work with the child perspectives and examine whether there is any difference in how the two national associations Riksorganisationen för kvinnojourer och tjejjourer i Sverige (Roks) and Sveriges kvinno- och tjejjourers riksförbund (SKR) applies the child perspectives. To examine this, we conducted interviews with six employees and one vol
The objective of this essay is to investigate if the performance of an Exchange-Traded Fund (ETF) share has an impact on the probability of closure of the same Exchange-Traded Fund. A great number of ETFs closures occurred in the last two years and the number of these closed ETFs represent a relevant percentage of the total number of ETFs that have been liquidated since this type of shares came to
A large-scale international report recently published by Transgender Europe shows great discrepancy between the patients’ and the caregivers’ views on transgender care. Apart from this report, those working in transgender care have yet to make their voices heard. However, transgender individuals as well as organizations working with issues of the transgender and queer communities in Sweden have be
Education is by the UN stated to be the foundation to creating sustainable development. Lately, there has been a tremendous increase in the use of information and communications technology (ICT) for educational purposes worldwide, but as many countries lag behind both in terms of uptake and usage of ICT, this limits their populations’ chances to participate. Given this, the aim of this thesis was
This project has been about understanding the public furniture market from a designers perspective and to develop a competitive design concept based on the needs of different stakeholders in the field of outdoor public products. The research has been mainly in forms of interviews and observations with a focus on Stockholm as geographical scope. I chose to focus on one city as the structure and r
This paper examines understandings of gender with an emphasis on masculinities among Bolivian feminist and women´s organizations. The specific aim has been to find out to what extent their understandings of gender include masculinities, and if so, what are their agendas and political positionings in relation to their work with men and boys. Finally, the study has examined what impact the feminist
