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Effects of peptide hydrophobicity on lipid membrane binding, incorporation, and defect formation was investigated for variants of the complement-derived antimicrobial peptide CNY21 (CNYITELRRQHARASHLGLAR), in anionic 1-palmitoyl-2-oleoylphosphatidylethanolamine (POPE)/1-palmitoyl-2-oleoylphosphatidylglycerol (POPG) and zwitterionic 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) membranes. Using a
An experimental study of methane + air flames doped with ammonia (4370 ppm of the fuel) has been performed. The goal of this work was to analyze formation of NOx from fuel-N under well-controlled conditions. The Heat Flux method was used for stabilization of non-stretched adiabatic flames on a perforated plate burner at atmospheric pressure. Laser-saturated fluorescence (LSF) and probe sampling we
This paper presents a method designed to identify underlying causes leading to industrial accidents. The method developed intends to facilitate the learning process from accidents by identifying possible causes related to the accidents that were not directly stated in an accident report, but that can be deduced following the description of the event, in particular with regard to the quality of the
Umbilical cord blood acid-base status at birth gives an objective evaluation of the fetal exposure and response to hypoxia during labor. The objective of this thesis was to elucidate methodological issues associated with interpretation of cord blood gases. DELAYED CORD BLOOD SAMPLING (Paper I): arterial and venous pH and bicarbonate decreased, and pCO2, base deficit (BD), and lactate increased sig
Popular Abstract in Swedish De flesta större operationer på hjärtat idag kräver att hjärtat under en del av operationen står stilla utan att blod cirkulerar igenom det. För att kunna bibehålla ett blodflöde av syresatt blod genom kroppen kopplas en hjärt-lungmaskin till patienten. Blodet förs via slangar från höger förmak först ner till ett uppsamlingskärl, varifrån blodet pumpas vidare genom en oThe use of cardiotomy suction during open heart surgery with cardiopulmonary bypass (CPB) has a long tradition and often regarded as mandatory. Recently, studies have described potentially negative effects of cardiotomy suction with activation of the complement system, enhanced inflammatory response, hemolysis and coagulopathy. Emboli of various matters has also been studied. Whether they affect t
Numerous fossil meteorites and high concentrations of sediment-dispersed extraterrestrial chromite (EC) grains with ordinary chondritic composition have previously been documented from 467 +/- 1.6 Ma Middle Ordovician (Darriwilian) strata. These finds probably reflect a temporarily enhanced influx of L-chondritic matter, following the disruption of the L-chondrite parent body in the asteroid belt
Weathering of soil minerals is important for the recovery from acidification and for the sustainability of forestry. However, there is still substantial uncertainty about its absolute rate. This study presents a harmonized comparison of field weathering rates estimated with the mechanistic model PROFILE and the depletion method for 16 intensively sampled soil profiles across Sweden representing di
By applying a novel approach to evaluate photofragmentation laser-induced fluorescence (PFLIF) imaging, experimental quantitative information on the temporal in-cylinder distribution of hydrogen peroxide (H2O2) in a homogeneous charge compression ignition (HCCI) engine was extracted. The results from PFLIF were then compared to those obtained from chemical kinetics simulations using computational
The Child and Adolescent Twin Study in Sweden (CATSS) is an ongoing longitudinal twin study targeting all twins born in Sweden since July 1, 1992. Since 2004, parents of twins are interviewed regarding the children's somatic and mental health and social environment in connection with their 9th or 12th birthdays (CATSS-9/12). By January 2010, 8,610 parental interviews concerning 17,220 twins had be
With the success of cisplatin (cis-diamminedichloroplatinum(II)), strong interest has developed in the application of inorganic metal complexes to the treatment of cancer. Research has focused on platinum( II) complexes with a variety of spectator ligands that provide novel physicochemical properties. In this paper we report a kinetic study of 1', 1'-bis(diphenylphosphino) ferrocenedichloroplatinu
BACKGROUND. In clinical transplantation the donor organ is perfused with a cold preservation solution to obtain quick core cooling and a suitable environment for the tissue cells. Without good preservation of the vasculature, progressive deterioration of the blood flow during reperfusion may ultimately lead to the no-reflow phenomenon, even though the function of the other cells in the organ may b
BACKGROUND/AIMS: The mechanism behind the uremic hyperhomocysteinemia has not been elucidated. Possibly, dialyzable uremic toxins play a role, e.g. as enzyme inhibitors. If so, the conditions for enzymatic removal would be expected to improve after dialysis. Therefore, we studied the postdialytic pattern of the plasma total homocysteine (tHcy) concentration. METHODS: We collected blood samples fro
An experimental system was developed for the rapid measurement of the aspiration/transfer efficiency of aerosol samplers in a wind tunnel. We attempted to measure the aspiration and particle transfer characteristics of two inlets commonly used for sampling airborne Particulate Matter ( PM): the 'Total Suspended Particulate' or TSP inlet, and the louvered 'dichotomous sampler inlet' typically used
L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-L-alanine (L-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact
Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland kvinnor i Sverige. Mer än 7000 kvinnor insjuknar varje år i bröstcancer, och cirka 1500 dör i sjukdomen. Incidensen av bröstcancer har stigit kontinuerligt sedan 1970-talet, och man uppskattar att en av tio kvinnor i Sverige kommer att utveckla bröstcancer någon gång under sin livstid. Den relativa överlevnaden i sjukdomeCancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to
Introduction Ihe association of physical inactivity with mortality, cardiovascular disease and cancer is extensively studied in adults. Clustering of cardiovascular risk factors and objectively measured physical activity in children and youth has not been convincingly established. The sustainability of objectively measured physical activity into adulihood is not satisfactorily studied. Acceleromet
The MAX IV storage rings, currently under construction in Lund, Sweden, will use third harmonic cavities operated passively to lengthen the bunches and alleviate collective instabilities. These cavities are an essential ingredient in the MAX IV design concept and are required for achieving the final design goals in terms of stored current, beam emittance, and beam lifetime-such performance challen
Background: There is a need for a rapid and cost-effective evaluation of the effects of different human papillomavirus (HPV) vaccination strategies. Sexually active adolescents are a preferred target group for monitoring, as effects on HPV prevalence would be measurable shortly after implementation of vaccination programs. Methods: The Swedish Chlamydia trachomatis testing program offers free Chla
This paper presents the development of an experimentally validated model that mechanistically comprehends the complex interaction between the gas-phase fluid dynamics, the mass transport of individual species, and the heterogeneous gas-surface reaction mechanism in a continuous cross-flow atomic layer deposition (ALD) reactor. The developed ALD gas-surface reaction mechanism, purely based on conse
Background and purpose MRI is the modality of choice when diagnosing spinal stenosis but it also shows that stenosis is prevalent in asymptomatic subjects over 60. The relationship between preoperative health-related quality of life, functional status, leg and back pain, and the objectively measured dural sac area in single and multilevel stenosis is unknown. We assessed this relationship in a pro
