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There is increasing evidence suggesting a role of intestinal dysfunction in a number of autoimmune diseases. Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with a documented increased level of intestinal inflammation, whereas multiple sclerosis (MS) is an organ-specific autoimmune disease known to exhibit increased intestinal permeability. In this study we determine to what exte
Background: Chronic subdural hematoma (cSDH) is one of the most common neurosurgical disorders and the incidence is rising. The routine treatment is neurosurgical hematoma evacuation, which is associated with recurrence rates up to 10–25%. In recent years, endovascular embolization of the middle meningeal artery (eMMA) has garnered much attention due to recurrence rates as low as < 5%. Several ran
BACKGROUND: Studies in men of European ancestry suggest prostate-specific antigen (PSA) as a marker of early prostate cancer (PCa) development that may help to risk-stratify men earlier in life.METHODS: We examined PSA levels in men measured up to 10+ years before a PCa diagnosis in association with PCa risk in 2,245 cases and 2,203 controls of African American, Latino, Japanese, Native Hawaiian,
Background: Sedation and analgesia are recommended during targeted temperature management (TTM) after cardiac arrest, but there are few data to provide guidance on dosing to bedside clinicians. We evaluated differences in patient-level sedation and analgesia dosing in an international multicenter TTM trial to better characterize current practice and clinically important outcomes. Methods: A total
Background: Targeted temperature management at 33 °C (TTM33) has been employed in effort to mitigate brain injury in unconscious survivors of out-of-hospital cardiac arrest (OHCA). Current guidelines recommend prevention of fever, not excluding TTM33. The main objective of this study was to investigate if TTM33 is associated with mortality in patients with vasopressor support on admission after OH
PURPOSE: To examine dietary exposure to 25 pesticide residues in several diet groups including omnivores, pesco-vegetarians, vegetarians and vegans while accounting for the farming system (organic or conventional) of plant-based foods consumed.METHODS: Organic and conventional consumption data in combination with data on pesticide residues in plant-based foods were used to derive estimated dietary
Background: Hypotension is common after cardiac arrest (CA), and current guidelines recommend using vasopressors to target mean arterial blood pressure (MAP) higher than 65 mmHg. Pilot trials have compared higher and lower MAP targets. We will review the evidence on whether higher MAP improves outcome after cardiac arrest. Methods: This systematic review and meta-analysis will be conducted based o
During the last decades, there has been continuous development of nationwide quality registries to assess healthcare and to do research in Sweden. An important background motive is the demographic transition resulting from an increasingly ageing population as one of the most important challenges of our time and a growing concern in many European countries and elsewhere. One condition for meeting t
In recent years, the need for sustainable practices within the food industry has become increasingly important and incorporating Industry 4 [...]
Aims: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose after hospital arrival are at high risk of mortality due to anoxic brain injury. MicroRNA are small-non-coding RNA molecules ultimately involved in gene-silencing. They show promise as biomarkers, as they are stable in body fluids. The microRNA 9-3p (miR-9-3p) is associated with neurological injury in trauma and
Objectives: During targeted temperature management after out-of-hospital cardiac arrest infusion of vasoactive drugs is often needed to ensure cerebral perfusion pressure. This study investigated mean arterial pressure after out-of-hospital cardiac arrest and the association with brain injury and long-term cognitive function. Methods: Post-hoc analysis of patients surviving at least 48 hours in th
Background: A prediction model that estimates survival and neurological outcome in out-of-hospital cardiac arrest patients has the potential to improve clinical management in emergency rooms. Methods: We used the Swedish Registry for Cardiopulmonary Resuscitation to study all out-of-hospital cardiac arrest (OHCA) cases in Sweden from 2010 to 2020. We had 393 candidate predictors describing the cir
Climatic conditions affect animals but range-wide impacts at the population level remain largely unknown, especially in migratory species. However, studying climate–population relationships is still challenging in small migrants due to a lack of efficient and cost-effective geographic tracking method. Spatial distribution patterns of environmental stable isotopes (so called ‘isoscapes’) generally
In order to alleviate the financial burden on the healthcare sector as well as relax its employees’ workload, there is a need to introduce novel tools that automate some of the tasks that today are performed manually. Especially pathology poses a problem with few pathologists, demanding manual labour and unnecessary work on benign tissue. As a response, the DOGS project aims to develop a tool to a
This Master's thesis in Sustainable Urban Design investigates the critical transformation of urban peripheral areas. Framed by the concept of "Alchemy of the Edge," it focuses on Westraven, Utrecht—a historically industrial and fragmented site. The project explores how design can facilitate Westraven's "Genesis as a Vibrant Decentralized Node," contributing to a more re
In 2023 an operator theoretic approach to the Prime Number Theorem was introduced by Olsen. In this thesis this approach is examined and applied to give a new, operator theoretic, proof of a different version of the Prime Number Theorem and of the Prime Number Theorem for arithmetic progressions. This approach is then expanded and rearranged to focus on the approximation error in the Prime Number
Digital breast tomosynthesis (DBT) has become a standard screening tool for breast cancer. However, its diagnostic performance is still limited compared to contrast-enhanced MRI, especially in women with dense breasts. Ultrafast dynamic contrast-enhanced (UF DCE) MRI and diffusion-weighted imaging (DWI) offer a shorter scanning time than conventional MRI and have shown promise in previous studies.
