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Patienters behandlingspreferenser har under de senaste tre decennierna uppmärksammats som en potentiell moderator för behandlingsresultat. En dubbelrandomiserad forskningsdesign, ”Doubly Randomised Controlled Preference Trial” (DRCPT), där patienter randomiseras antingen till ett val mellan behandlingar eller till slumpmässig fördelning till en av behandlingarna, anses vara en av de mest lämpliga Patient preferences have drawn considerable attention as a potential moderator of treatment outcome. The Doubly Randomised Controlled Preference Trial (DRCPT) in which patients are randomised to a choice between two or more treatments or random assignment to one of these same treatments is considered one of the most rigorous tests of the effects of patient preferences on outcomes. To date, there h

This study aims to explore how physicians make sense of and give meaning to their decision-making during obstetric emergencies. Childbirth is considered safe in the wealthiest parts of the world. However, variations in both intervention rates and delivery outcomes have been found between countries and between maternity units of the same country. Interventions can prevent neonatal and maternal morb

Background Tuberculosis is among the leading causes of death among infectious diseases. Regions with a high incidence of tuberculosis, such as sub-Saharan Africa, are disproportionately burdened by stillbirth and other pregnancy complications. Active tuberculosis increases the risk of pregnancy complications, but the association between latent tuberculosis infection (LTBI) and pregnancy outcomes i

In all times, societies have known social hierarchies and boundaries between individuals and groups with distinct social characteristics. The extent to which such hierarchies and boundaries are consequential for life outcomes and persist over time differs between societies. These changes over generations in the social structure, and the social, economical, and institutional developments that shape

Purpose: To assess the ability of quantitative pupillometry [using the Neurological Pupil index (NPi)] to predict an unfavorable neurological outcome after cardiac arrest (CA). Methods: We performed a prospective international multicenter study (10 centers) in adult comatose CA patients. Quantitative NPi and standard manual pupillary light reflex (sPLR)—blinded to clinicians and outcome assessors—

The research group from Humanities laboratory at Lund University, Sweden, presents three strands of research on language and cognition where eye-tracking methodology has been used as a window on the mind. The paper includes: (1) eye tracking studies on picture viewing and picture description showing the dynamics of how speakers perceive, conceptualize and spontaneously describe complex visual scen

Almost thirty years ago the criteria that are currently used to verify claims for the discovery of a new element were set down by the comprehensive work of a Transfermium Working Group, TWG, jointly established by IUPAC and IUPAP. The recent completion of the naming of the 118 elements in the first seven periods of the Periodic Table of the Elements was considered as an opportunity for a review of

Background: Voluntary self-exclusion from gambling is a common but underdeveloped harm reduction tool in the management of gambling problems or gambling disorders. Large-scale, multi-operator, and operator-independent self-exclusion services are needed. A recent nationwide multi-operator self-exclusion service in Sweden (Spelpaus), involving both land- and web-based gambling sites, is promising, b

Static analysis tools play a crucial role in software development by detecting bugs and vulnerabilities. However, running these tools separately from the code editing process often causes developers to switch contexts, which can reduce productivity. Previous work has shown how Reference Attribute Grammars (RAGs) can be used for declarative implementation of competitive tooling for intraprocedural

In a Swedish sample of persons eligible for disability services and aged 55 years or older in 2012, persons (n = 601) with autism spectrum disorder diagnoses registered in specialist care were identified. Register data concerning diagnoses of other psychiatric disorders, psychiatric care, and psychiatric medication were reviewed. More than 60% had been in contact with psychiatric care. The majorit

This paper discusses the existence and scope of the morality exception from patentability, in Article 53 (a) of the European Patent Convention. The analysis will look into the history of the provision, debate its rational and interpretation by reference to three examples of technology areas: stem cell research; gene editing and AI/big data analytics.Bioscience innovation has always generated heate

The utility of mRNA and protein determinations of G protein-coupled receptor 35, that is, GPR35a (GPR35 V1) and GPR35b (GPR35 V2/3), as indicators of outcome for colon cancer patients after curative surgery was investigated. Expression levels of V1 and V2/3 GPR35, carcinoembryonic antigen and CXCL17 mRNAs were assessed in primary tumours and regional lymph nodes of 121 colon cancer patients (stage

Background: Sedation is routinely administered to critically ill patients to alleviate anxiety, discomfort, and patient-ventilator asynchrony. However, it must be balanced against risks such as delirium and prolonged intensive care stays. This study aimed to investigate the effects of different levels of sedation in critically ill adults. Methods: Systematic review with meta-analysis and trial seq

BackgroundOver the last decades, many strategies to procure and improve xylose consumption in Saccharomyces cerevisiae have been reported. This includes the introduction of efficient xylose-assimilating enzymes, the improvement of xylose transport, or the alteration of the sugar signaling response. However, different strain backgrounds are often used, making it difficult to determine if the findin

Retrieving episodic memories often involves reconstructing both their semantic content and the emotional context in which they occurred. However, the neural mechanisms that differentiate these forms of reinstatement remain poorly understood. This event-related potential (ERP) study examines how semantic category and emotional valence are reinstated during memory retrieval.Seventy participants enco

This paper describes a knowledge integration framework for robotics, whose goal is to represent, store, adapt, and distribute knowledge across engineering platforms. The architecture abstracts the components as data sources, where data are available in the AutomationML data exchange format. AutomationML is an on-going standard initiative that aims at unifying data representation and APIs used by e