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On-site hydrogen gas production from hydrogen-rich liquids offers a clean alternative to fossil fuels for combustion that is readily implemented in existing energy infrastructure. A heterogenized (POCOP)-Ir pincer catalyst can be operated at higher temperatures for higher turnover frequency, but the reaction pathway of the reported complex has not been well understood. Here, we report intermediary
Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM
Populärvetenskaplig sammanfattning: Allt fler rapporter har kommit under de senaste åren som visar på att våg- och stormklimatet har förvärrats sedan 1960-talet. Detta har oroat bland andra återförsäkringsbolag som har betalat ut allt mer pengar till stormrelaterade skador de senaste åren. Andra undersökningar har visat att det nuvarande storm- och vågklimatet inte är värre än det var i början av The effects of a global climatic change on the wind climate of northwestern Europe are investigated with the aid of a regional climate model. There have up to date been few studies of how the wind climate will react to a greenhouse gas warming. Those that have been done are mostly global scale studies and centered on changes in storm activity during the winter season. I’m using data from a regiona
With their superficially shark-like appearance, the Mesozoic ichthyosaurs provide a classic illustration of major morphological adaptations in an ancestrally terrestrial tetrapod lineage following the invasion of marine habitats1, 2–3. Much of what is known about ichthyosaur soft tissues derives from specimens with body outlines4, 5–6. However, despite offering insights into aspects of biology tha
Independence and collaboration both play crucial roles in PhD students’ research practice and in their socialization into the PhD role. This study examines how theexpectation of PhD students' academic independence intersects with the need for more collaborative engagements within research groups. Drawing on interviews with supervisors and an analysis of co-authorship patterns in PhD studentdissert
Animals live in diverse environments and have evolved to cope with environmental challenges in different ways. How such adaptations shape overall brain morphology is still unclear. Here, we test how two behavioural adaptations – circadian activity pattern and migratory behaviour – are reflected in the brains of moths and butterflies (Lepidoptera). We predicted that circadian activity pattern affec
OBJECTIVES: Asphalt is frequently used as road pavement and consists of bitumen as a binder, and fillers. Bitumen consists of a complex mixture of hydrocarbons, where a minor component is polycyclic aromatic hydrocarbons (PAHs). Many PAHs are classified as carcinogenic to humans. Bitumen fumes from road paving have been classified as possibly carcinogenic. Paving and milling are open processes gen
Purpose: Biokinetic and dosimetry studies in laboratory animals often precede clinical radionuclide therapies in humans. A reliable evaluation of therapeutic efficacy is essential and should be based on accurate dosimetry data from a realistic dosimetry model. The aim of this study was to develop an anatomically realistic dosimetry model for Brown Norway rats to calculate S factors for use in eva
Skiljedomsrätt är sedan urminnes tider en använd tvistelösningsmetod. Hänvisningar till skiljerätt finns att hitta i både romersk och gammalgrekisk rätt, så som Digesta, Codex Iustinianus och Novellae. Även Sverige har en lång tradition av kommersiellt skiljeförfarande och metoden har nyttjats som ända sedan Hansan etablerades. Förmodligen har skiljeförfarandet även använts för att avgöra kommersiArbitration is an immemorial dispute settlement method with references to be found in both Roman and ancient Greek law, such as Digesta, Codex Iustinianus and Novellae. Sweden also has a long tradition of commercial arbitration and it has been used as a dispute settlement method at least since the Hanseatic League was established. It is also believed that arbitration was used to settle commercial
Metangas bidrar med en signifikant andel till den rådande växthuseffekten på jorden. I nutid är den största källan till utsläpp av metangas våtmarker i jämförelse med andra naturliga utsläppskällor. Emissioner av metangas från våtmarker är beroende av klimatet och har den egenskapen att ge en positiv återkoppling till klimatändringen. Icke desto mindre finns det dock stor osäkerhet associerat med Popular science Global warming is a significant environmental problem now-a-days. Methane is a major greenhouse gas causing global warming by trapping long wave radiations from the Earth. Presently, natural wetlands are responsible for the largest amount of emissions of this gas when compared to other natural sources. Changing climate impacts the emissions from wetlands which in turn further inten
Aims Oral anticoagulation with vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF) is effective but has significant limitations. AZD0837, a new oral anticoagulant, is a prodrug converted to a selective and reversible direct thrombin inhibitor (AR-H067637). We report from a Phase II randomized, dose-guiding study (NCT00684307) to assess safety, tolerability, pharmacokinet
By employing seven semi-structured interviews with local judges and prosecutors in Kosovo, this study aims at examining how the European Union Rule of Law Mission (EULEX) has impacted the legal order in Kosovo and the practice of the judges and prosecutors. In addition, this study examines how the impacts of EULEX, and how the judges and prosecutors will be affected after the EULEX are withdrawn f
Introduction TCP-25 gel is intended for use in treatment of wound infection and inflammation. Current local therapies for wounds have limited efficacy to prevent infections and there are no wound treatments available today that target the excessive inflammation that often hampers wound healing in both acute and chronic wounds. There is therefore a high medical need for new therapeutic alternatives
BACKGROUND: Tuberculosis remains a leading infectious cause of death in resource-limited settings. Effective treatment is the cornerstone of tuberculosis control, reducing mortality, recurrence and transmission. Supporting treatment adherence through facility-based observations of medication taking can be costly to providers and patients. Digital adherence technologies (DATs) may facilitate treatm
Firefighters are occupationally exposed to a large number of toxic compounds (IARC 2010). The occupational exposure of firefighters has been classified as potentially carcinogenic (class 2B, IARC; (Straif K. et al. 2007)). Poorly quantified emission factors and low understanding of when various aerosol emissions are likely to form during a fire event (initiation, combustion, extinguishing) inhibit
Detta är den tionde årsrapporten från Svensk Dagfjärilsövervakning, ett nationellt miljöövervakningsprogram som koordineras av Lunds universitet på uppdrag av Naturvårdsverket sedan 2010. Svensk Dagfjärilsövervakning är ett samarbete mellan Sveriges Entomologiska Förening, Naturvårdsverket, Lunds universitet, Sveriges lantbruksuniversitet och Länsstyrelserna. Verksamheten möjliggörs av frivilliga
