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Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fracture applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55 years; and comprising 329 cases and 2666 controls with radiographic
There is concern over the high risk of cardiovascular complications, hypertensive disorders, and other adverse obstetric outcomes among pregnant women with Turner syndrome (TS). A diagnosis of TS is made in some women late in life or not at all. Spontaneous pregnancies are rare in women with TS and are associated with a high rate of complications, especially miscarriage. The use of assisted reprod
The testis is a radiosensitive tissue. It contains a large number of lobules, which in turn are composed of convoluted seminiferous tubules. The epithelium inside each tubule consists of a complex mosaic of supporting cells and germ cells of different sizes and degrees of maturation. These cells are known to have diverse sensitivity to radiation, those with the highest sensitivity being the sperma
Automated classification of ECG patterns is facilitated by careful selection of waveform features. This paper presents a method for evaluating the properties of features that describe the shape of a QRS complex. By examining the distances in the feature space for a class of nearly similar complexes, shape transitions which are poorly described by the feature under investigation can be readily iden
This report is a compilation of papers written by architects, engineers and planners from Africa, Asia and Latin America, involved in housing and urban development with a focus on the urban poor. The papers present projects for change and improvements within the frame of an inter-national training programme offered by Housing Development and Management (HDM) Lund University, carried out in conjunc
The paper reports a project conducted within the framework of the National Library of Sweden's Expert Group on Library Statistics. The project is financed by the National Library of Sweden, and it aims to capture how library managements make use of the current library statistics (based on the ISO-standard) in the decision-making process. Questions are also asked about the quality and usefulness of
We consider the problem of modeling and control of the nonlinear dynamics of a micro manipulator, utilized for machining operations in combination with industrial robots. Position control of the micro manipulator is a challenging problem because of the actuation principle, which is based on piezo-actuators with inherent nonlinear behavior. The major nonlinearities in the manipulator are identified
Treatment with metformin in type 2 diabetes mellitus-new routines when renal function is reduced and in connection with administration of iodine contrast media Metformin is eliminated through glomerular filtration and tubular secretion in the kidneys. New guidelines recommend use of metformin down to a GFR of 30 mL/min under the condition that the dose is adjusted. As the risk of inducing lactic a
The latitudinal diversity gradient (LDG) is one of Earth’s most iconic biodiversity patterns and still one of the most debated. Explanations for the LDG are often categorized into three broad pathways in which the diversity gradient is created by (1) differential diversification rates, (2) differential carrying capacities (ecological limits), or (3) differential time to accumulate species across l
I omställningen till en mer hållbar bioekonomi har mycket fokus legat på utvecklingen av biobränslen. När det gäller innovation och utveckling av kemikalier och andra produkter släpar utvecklingen efter av flera orsaker, vilket visas i denna avhandling.Forskningen visar att det nuvarande systemet är inlåst i ett fossilberoende av flera olika orsaker, både tekniska, organisatoriska och materiella. The transition to a bioeconomy is dependent on transformative changes to technologies, organisations, and institutions, which jointly can be described as a socio-technical change. The thesis contributes to the understanding of how the transition is shaped by expectations on and collaborations for innovation forbiorefineries, which can produce chemicals, fuels, and materials needed in a bioeconomy.
The aim of this paper is to study how local governments in Sweden view the role of public transport in society, and to investigate how public transport is used in a strategic capacity. By studying general policy documents, the ambition is to gain a wider understanding of the role of public transport based on the societal context it is situated in. Documents from 15 regions and 27 municipalities ha
The effects of charge overlap, or charge penetration, are neglected in most force fields and interaction terms in QM/MM methods. The effects are however significant at intermolecular distances near the van der Waals minimum. In the present study, we propose a method to evaluate the intermolecular Coloumb interaction using Slater-type functions, thus explicitly modeling the charge overlap. The comp
An X-ray grating interferometer (GI) suitable for clinical mammography must comply with quite strict dose, scanning time and geometry limitations, while being able to detect tumors, microcalcifications and other abnormalities. Such a design task is not straightforward, since obtaining optimal phase-contrast and dark-field signals with clinically compatible doses and geometrical constraints is rema
This review summarizes the analytical methods that have been developed for quantification and characterization of oat proteins. These include sampling, sample preparation, extraction, quantification, separation, detection, and characterization of oat proteins. The review also provides a comparison of different methods for the determination of protein fraction of oat and the efficiency thereof. We
Fungi have the capacity to cause devastating diseases of both plants and animals, causing significant harvest losses that threaten food security and human mycoses with high mortality rates. As a consequence, there is a critical need to promote development of new antifungal drugs, which requires a comprehensive molecular knowledge of fungal pathogenesis. In this review, we critically evaluate curre
Bodnar and Schmid (2008) derived the distribution of the global minimum variance portfolio weights and obtained the distribution of the test statistics for the general linear hypothesis. Their results are obtained in the case when the number of observations n is bigger or equal than the size of portfolio k. In the present paper, we extend the result by analyzing the portfolio weights in a small sa
