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BACKGROUND: Plasma biomarkers for Alzheimer's disease (AD) have broad potential as screening tools in primary care and disease-modifying trials. Detecting elevated amyloid-β (Aβ) pathology to support trial recruitment or initiating Aβ-targeting treatments would be of critical value. In this study, we aimed to examine the robustness of plasma biomarkers to detect elevated Aβ pathology at different
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of methylxanthine administration on the incidence of apnea and longer-term clinical outcomes in preterm infants including infants at risk for or having apnea and preterm infants peri-extubation.
Stem cell therapy using human skin-derived neural precursors holds much promise for the treatment of stroke patients. Two main mechanisms have been proposed to give rise to the improved recovery in animal models of stroke after transplantation of these cells. First, the so called by-stander effect, which could modulate the environment during early phases after brain tissue damage, resulting in mod
Unsatisfactory indoor air quality (IAQ) can result from emissions of volatile organic compounds from the materials of the building. A surface emissions trap (cTrap) can be used to stop such emissions thus preventing them from reaching the indoor air. The present study concerned an apartment where the tenants experienced skin and mucous membrane irritation due to moisture-driven emissions from the
We examine a two-dimensional Coulomb gas consisting of n identical repelling point charges at an arbitrary inverse temperature β, subjected to a suitable external field. We prove that the gas is effectively localized to a small neighbourhood of the droplet – the support of the equilibrium measure determined by the external field. More precisely, we prove that the distance between the droplet and t
Most commercial prosthetic hands lack closed-loop feedback, thus, a lot of research has been focusing on implementing sensory feedback systems to provide the user with sensory information during activities of daily living. This study evaluates the possibilities of using a microphone and electrotactile feedback to identify different textures. A condenser microphone was used as a sensor to detect th
Safety, perceived and real, is essential for the attractiveness of urban environments (Avraham & Ketter, 2008, Coaffee & van Ham, 2008, Avraham, 2009). A high degree of perceived safety of a place plays a large role in attracting retail businesses, personnel, and customers. However, perceived safety is not an isolated issue, but related to many aspects, such as the planning of city space,
The bloom-forming freshwater alga Gonyostomum semen is associated with acidic, mesotrophic brown water lakes in boreal regions. However, researchers have been unable to conclusively link G. semen abundance and bloom formation to typical brown water lake traits, that is, high water color and DOC (dissolved organic carbon) concentrations. Iron is a main driver of water color in boreal lakes, and a r
The Nordic feminist perspectives in law have traditionally been relatively successful in advocating, and effectuating, a feminist perspective of justice both within law and the society. However, Nordic feminist perspectives of law have at least to some degree, at this stage been limited to questions of equality between men and women and to the production of justice within the boundaries of the nat
Citation counts have long been considered as the primary bibliographic indicator for evaluating the quality of research—a practice premised on the assumption that citation count is reflective of the impact of a scientific publication. However, identifying several limitations in the use of citation counts alone, scholars have advanced the need for multifaceted quality evaluation methods. In this st
The longevity of the almost 100-year-old Ålandic autonomy has been attributed to, among other things, its ability to evolve and adapt to changing circumstances. This position can be problematized and qualified in at least four ways: firstly, most initiatives to develop the autonomy have come from the Ålandic and not the Finnish side; secondly, the processes leading up to the adoptions of new Auton
Translation is controlled by numerous accessory proteins and translation factors. In the yeast Saccharomyces cerevisiae, translation elongation requires an essential elongation factor, the ABCF ATPase eEF3. A closely related protein, New1, is encoded by a non-essential gene with cold sensitivity and ribosome assembly defect knock-out phenotypes. Since the exact molecular function of New1 is unknow
A novel life-cycle assessment (LCA) model has been developed for the investigation of the environmental impact of the choice of material in cable production. In the first application polyolefin based material and PVC material is used. In both cases equivalent fire behaviour is assumed and a fire model is established based on existing fire statistics. This study represents the second full applicati
In this paper we derive error estimates of the backward Euler–Maruyama method applied to multi-valued stochastic differential equations. An important example of such an equation is a stochastic gradient flow whose associated potential is not continuously differentiable but assumed to be convex. We show that the backward Euler–Maruyama method is well-defined and convergent of order at least 1/4 wit
This article describes how a wheel–rail wear detection parameter based on noise was developed by running a rapid transit train instrumented with microphones in a depot with a small curve radius. This full-scale test made use of previous knowledge gained from lab-scale tests. The lab- and full-scale tests showed that noise could be used as an indicator of wear transition, when normal wear turns int
The present invention relates to the use of an ester of inositoltrisphosphate for the preparation of a medicament for preventing, alleviating or combatting inflammatory conditions in mammals including man. Injury or destruction of tissues should be understood as damage to an aggregation of specialized cells with a particular function both internally and externally in the body, such as different or
Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortco
There is a never-ending quest for a stable economy with full employment and low inflation. Economists have suggested and policymakers have experimented with different fiscal and monetary policy regimes since at least the beginning of the industrial revolution. In this paper, we study Swedish stabilization policies through six policy regimes between 1873 and 2019. We focus on discretionary stabiliz
In this paper we make three points about the current state and promising future directions of qualitative research in our field of innovation policy research. First, we argue that research design and methods are dealt with quite superficially in most innovation policy studies papers and journals providing little guidance to new scholars as to how to approach their research. Secondly we argue that
