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Popular Abstract in Swedish Parkinsons sjukdom uppstår när celler som producerar signalsubstansen dopamin i hjärnan dör. Detta leder till att de drabbade patienterna blir stela, får långsamma rörelser, svårt att påbörja och avsluta rörelser och även skakningar i framförallt armar och händer. Idag finns inget sätt att bota sjukdomen. Dock finns det läkemedel som kan lindra symptomen. Den vanligasteThe main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. The gold standard medication is

Objective: Interstitial laser coagulation (ILC) of the prostate is a minimally invasive method for treating symptomatic benign prostatic enlargement (BPE). We performed a prospective randomized study to compare the clinical outcomes of ILC and transurethral resection of the prostate (TURP). Material and Methods: Between December 1997 and February 2000, 38 patients with moderate-to-severe symptomat

Peptidoglycan from Staphylococcus aureus mobilized CD66b in human neutrophils but did not upregulate surface activation markers in eosinophils. In addition, Toll-like receptor 2, implicated in the recognition of peptidoglycan, was detected on the surface of resting neutrophils but not on eosinophils. These findings suggest roles for neutrophils but not eosinophils in innate recognition of peptidog

A new type of liposomal liver-specific contrast medium was studied in an experimental tumour model. Rabbits were inoculated with VX2-carcinoma directly in the liver of laparotomy. CT studies were carried out 14 days after inoculation. The liver-specific contrast medium consisted of a suspension of liposomes in a 100 mg I/ml iodixanol solution, with equal amounts of encapsulated and nonencapsulated

Complement, which bridges innate and adaptive immune responses as well as Immoral and cell-mediated immunity, is antiviral. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a lytic cycle protein called KSHV complement control protein (KCP) that inhibits activation of the complement cascade. It does so by regulating C3 convertases, accelerating their decay, and acting as a cofactor for factor

This thesis provides an account of the storage strategies for mitigation of excess electricity production (EEP) from wind energy in the Öresund region of Denmark and southern Sweden, characterized by an increasing share of wind power. Hydrogen is a versatile storage technology with potential in both large and small scale options, and for utilization in several application areas. TIS framework and

Popular summary The environmental and social consequences of predicted climate change are expected to be amplified in urban environments due to their elevated temperatures, which are attributable to a phenomenon known as the Urban Heat Island. As most types of vegetation can provide for cooler air temperatures due to their natural cooling effect, increasing amounts of vegetation in urban areas mig

Large quantities and numbers of organic compounds (OCs) from industries and domestic sources enter the wastewater treatment plants (WWTPs) everyday, which is an ever-increasing issue in modern society. In WWTPs, the pollutants are either degraded or emitted to the air, the effluent (water) or the sludge (biosolids). Even though the sludge may contain toxic contaminants and heavy metals, there is a

With a legal dogmatic method, the purpose of this thesis was to examine how Vietnam is fulfilling its legal obligations to support returning human trafficking victims. The Vietnamese human trafficking law was the main research object and was considered in relation to the international standards in support to returnees set in the Trafficking Protocol. It also aimed to identify shortcomings, and ass

Reklam har olika budskap för att påverka och influera oss. Denna uppsats syftar till kvalitativt undersöka hur samhällsideal och normer konstrueras i sex specifika Calvin Klein parfym reklamfilmer. Vidare syftar studien till att studera hur reklamfilmerna använder sig av genusrelaterade konstruktioner och stereotypa bilder. Den här uppsatsen har schematiskt tittat på ett bestämt antal aspekter i a

Fluorescence in situ hybridization (FISH) with a locus-specific dual DNA probe (LSI EGR-1SO/D5S23SG) for chromosome 5 was used in combination with morphology to study bone marrow cell lineage involvement of the abnormal chromosomal clone in 13 patients with deletion 5q[del(5q)], either as a sole aberration or as part of a complex karyotype, and in six cases with monosomy 5 by metaphase cytogenetic

Objective. To evaluate the longitudinal development of the tricuspid gradient (TG) for screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Methods. Doppler echocardiography was performed 506 times in order to estimate TG in 227 consecutive patients with SSc. The value of biochemical markers for predicting TG levels and development was assessed through analyses of pro-b

Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur in the injured human brain and be implicated in the neurodegenerative aftermath of

The present study focuses on introducing the concept of optimisation and proposing a model, including evaluation of image quality, to be used in the clinical routines where image-guided intervention is being performed. The overall aim of the study was to develop a model for evaluating the use of imaging in X-ray-guided interventional procedures and its possible implications on optimisation of radi

The Jk(a-b-) phenotype results from alterations in the JK gene and is characterized by absence of the RBC urea transporter in the cell membrane. The frequency of Jk(a-b-) varies among populations, but this phenotype is most commonly found in people of Polynesian and Finnish descent. Although rare, Jk(a-b-) individuals present a clinical challenge because anti-Jk3 is produced readily in response to

Here, we present a revised protocol to derive neuroepithelial stem (NES) cells from human induced pluripotent stem cells. NES cells can be further differentiated into a culture of neurons (90%) and glia (10%). We describe how to derive and maintain NES cells in culture and how to differentiate them. In addition, we show the potential use of NES cells to study the role of reactive oxygen species in

In 2018, a strategy for Sweden's first National Forest Program was launched. As part of its implementation, County Administrative Boards have initiated dialogue processes for drafting regional forest strategies. Stakeholder deliberation is ascribed the potential to promote trust and mutual understanding, lead to more robust decisions and smoother implementation. We examine the dialogue processes,