Filtyp
INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevention of ischemic stroke. PATIENTS AND METHODS: Oral faCtor Eleven A iNhibitor asundexian as novel ant
This paper summarized the efforts performed to understand decay heat estimation from existing spent nuclear fuel (SNF), under the auspices of the Working Party on Nuclear Criticality Safety (WPNCS) of the OECD Nuclear Energy Agency. Needs for precise estimations are related to safety, cost, and optimization of SNF handling, storage, and repository. The physical origins of decay heat (a more correc
Chiral compounds containing nitrogen heteroatoms are fundamental substances for the chemical, pharmaceutical and agrochemical industries. However, the preparation of some of these interesting scaffolds is still underdeveloped. Herein we present the synthesis of a family of P-stereogenic phosphinooxazoline iridium catalysts from L-threonine methyl ester and their use in the asymmetric hydrogenation
Water resources management has been reconfigured over time and space; as power over decision-making processes has increasingly been vested from the state and distributed among networks of private and non-governmental actors. Geographical scholarships of environmental governance seek to critically analyse this transformation in order to grasp how decisions are made, and the consequences that entail
The impact of different climate scenarios, drought, and water level management on the outflow water quality of peatlands has been investigated. A mesocosm experiment has been conducted within climate control chambers to simulate current (2016–2019 real-time) and future representative concentration pathway (RCP) climate scenarios (RCP 2.6, 4.5 and 8.5). To assess the efficiency of a management stra
The late Cambrian Steptoean positive carbon isotope excursion (SPICE) represents a major perturbation to the global carbon cycle and was associated with trilobite extinctions and expansion of anoxic and/or euxinic water masses during episodes of eustatic sea-level change. We present a new Re-Os age together with Os and Nd isotope stratigraphy and major and trace-element data from the Alum Shale Fo
Background: Medication discrepancies are common, potentially harmful and may result from poor medication information across medical records. Our aim was to describe current medication discrepancy rates, types and severity in hospital, primary and specialized outpatient care in Sweden, as well as comparing these with previous measurements. Methods: Participants visiting health care in Skåne in Nove
Background: The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract surgery. The purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France, to assess its psychometric properties via Rasch analysis, and to assess its validity when completed using an electronic notepad. Methods: The Catquest-9SF questionn
Children's participation in economic activities has been documented as an inseparable part of the family support network in childhood studies. Children as an integral part of the parents' world contribute to enhanced social experiences, the continuity of the societal system, and the holistic well-being of the family. In the pro- baby global south children are political, economic, cultural, and soc
The COVID-19 pandemic and its societal impact may cause long-term behavioral changes in alcohol use due to increased psychological distress, unemployment, and time spent home. The purpose of this study was to determine whether or not the COVID-19 pandemic had a significant impact on treatment seeking for alcohol use disorders and related problems in a Swedish psychiatric treatment facility. Using
In recent years, researchers have extensively investigated hepatocellular carcinoma (HCC), a prevalent cancer type worldwide. Its resistance to conventional treatments highlights the promise of theragnostic nanoparticles, offering multiple tools within a single platform for fighting HCC cells. In this research, using polyaniline (PANI)-coated cobalt ferrite nanoparticles (CFO), an innovative nanoc
School-related functional impairment is common in children and adolescents with obsessive-compulsive disorder (OCD). However, little is known about the characteristics of youth with OCD who struggle in school, whether these struggles interfere with treatment outcomes, and whether treatment improves school-related function. Among 385 youth with OCD at a specialist clinic (mean age [sd] = 13.7 [2.5]
The occurrence of climate change will have a significant impact on society and adapting to a more sustainable environment is of key importance. The dangers of climate change will include temperature and precipitation patterns becoming more extreme creating a substantial impact on society. Greece’s location and climate make it particularly vulnerable to a changing climate and climate impact assessm
Mountains provide a variety of ecosystem services, such as drinking water, which sustains not only mountain communities but also people living further downstream. While climate change threatens most ecosystems, its negative impacts are up to three times greater in high altitudes. As well as changing the water cycle this further accelerates climate change. Although they contribute comparably little
Saccharomyces cerevisiae is a commonly used industrial organism which cannot consume xylose naturally. This is a problem since xylose is a major component in renewable resources, for instance lignocellulose. The Weimberg pathway is a pathway that converts xylose into α-ketoglutarate. It has been successfully integrated into S. cerevisiae, enabling it to utilize xylose. The successful strain had th
Jämfört med många andra industrier så har byggnadsindustrin halkat efter med att implementera digitala lösningar. I dagsläget är det enbart ett fåtal materialleverantörer och tillverkare som erbjuder en tjänst av så kallade digitala BIM-objekt till sina produkter. Dessa digitala produkt kopior kan nyttjas för flera syften i projektmodeller vilket exempelvis gynnar desing-team och entreprenörer. DeThe construction industry has in general been rather slow in its implementation of new digital solutions compared to other industries. To date, only a handful of material suppliers are offering a service of so-called digital BIM-objects of their products. These 'digital product copies' can be utilized in projects' BIM-models for several purposes, being favorable to the design team and
Japan currently faces a rapid increase in labor immigrants due to the decrease of the population. The number of immigrant children is expected to increase because of the open labor immigration policy. Although the education of immigrant children is very complex, Hamamatsu city and Kani city have implemented successful educational policies to solve the problems of out-of-school children. This resea
Across the world, there is a call to combat the climate crisis and tackle growing socio-economic inequalities. The Danish Citizens’ Assembly on Climate (CAC) is a case of attempted deliberative democracy seeking pathways to this outcome. This thesis asks how the CAC might catalyse a Danish sustainability transition. With democratic discourse theory and the concept of just sustainability, I conduct
Statistical comparison of single cases to small samples is a methodology that has been extensively used in, for example, cognitive and clinical neuropsychology. This is most often done to determine changes in cognitive processing after an individual has incurred some type of brain damage. In a clinical setting one often wish to infer whether a patient exhibit abnormally low performance on some cog
