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The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc
The Nordic countries offer an ideal case study of the COVID-19 pandemic due to their comparability, high data quality, and variable mitigations. We investigated the age- and sex-specific mortality patterns during 2020–2021 for the five Nordic countries and analysed the total age- and sex-adjusted excess deaths, ratios of actual to expected death rates, and age-standardized excess death estimates.
The Last Interglacial (LIG) experienced substantial changes in seasonal insolation compared with the present day, which may have affected the hydrography and water-mass exchange in the North Sea and Baltic Sea region. Here we investigate the effects of solar radiation and greenhouse gas (GHG) forcing on the regional climate by analyzing model simulations of the LIG (127 ka BP), pre-industrial (PI,
Introduction: It is well known that urinary tract infection (UTI) during pregnancy is associated with preterm birth, but information about the risk of preterm birth depending on gestational week of infection is sparingly described in the literature. Material and Methods: An observational study based on data from Swedish registers including women giving birth 2014–2020 (n = 684 595). Pregnant women
Bacteria encode diverse defence systems, including restriction-modification and CRISPR-Cas, that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate that many recently identified antiphage defence operons comprise a nuclease and NTPase protein, suggesting that additional nucleic acid-targeting systems remain to be understood. Here we develop large-scale compa
Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HD ON) state, a relaxed catalytically inactive (HD OFF/SYNTH OFF) state, and an elongated synthesis-competent (SYNTH ON) state, whereas RelA samples only the latter two. The distribution of these states is controlled by starved ribos
At Dagsmosse in south-central Sweden, evidence from well-preserved Mesolithic wetland sites (10,200–7000 cal a BP) demonstrates occupation continuity among Hunter-Gatherer-Fisher (HGF) communities in wetland areas. This study presents detailed environmental reconstructions of the Dagsmosse basin, where Mesolithic fishing and dwelling activities were recorded. Focusing on the Preboreal–Boreal biozo
Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates
Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR
Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment inter
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic re
We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in Östergötland County (population ≈465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time la
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi
Climate models have continued to be developed and improved since the AR4, and many models have been extended into Earth System models by including the representation of biogeochemical cycles important to climate change These models allow for policy-relevant calculations such as the carbon dioxide (CO2) emissions compatible with a specified climate stabilization target. In addition, the range of cl
Skyddsombud - varmt välkomna till oss i Samordningsgruppen! 2025-02-26 Presentation av Samordningsgruppens pågående arbete med leveransmålen i delprojektet Organisation och styrning Att tänka på: Finns inga beslut. Allt är pågående arbete och diskussion! Vi i Samordningsgruppen är: • Katarina Hedlund • Petter Pilesjö • Anders Scherstén • Yann Clough • Anna Maria Jönsson • Raimund Muscheler • Anna
https://www.naturvetenskap.lu.se/internt/sites/naturvetenskap.lu.se.internt/files/2025-02/Skyddsomb%2026feb25.pdf - 2026-07-08
Judit Staller Doktorand judit.staller@miun.se Salutogent arbetssätt i äldreomsorgen – med fallet Anna Syfte: Förklara salutogenes arbetssätt och förhållningssätt begripligt och användbart i vardagen Salutogenes — definition och nycklar ”Hälsans ursprung” (Antonovsky) Nyckelfråga: Vad gör att vissa behåller hälsan trots stress och motgångar? Svar: De har resurser och en känsla av sammanhang (KASAM)
Kursplan Flygbolagsoperationer i flerpilotsmiljö LIA FLL35a Kursplan KURSENS NAMN: Flygbolagsoperationer i flerpilotsmiljö. KURSKOD: FLL35a POÄNG: 50 FASTSTÄLLD: Godkänd av YH ledningsgrupp 2022-03-07 REVIDERAD: 2026-03-02 GÄLLER FÖR: Utbildningsomgång YH01518-2021-1 och YH01518- 2021-2, YH01518-2023-1, YH01518-2023-2, YH01518-2023-3 TYP AV KURS OCH DESS INPLACERING I UTBILDNINGSSYSTEMET: Kursen ä
KURSUTVÄRDERING 2026-03-24 Postadress Besöksadress Telefon E-post Webbadress Box 207 Lilla Gråbrödersgatan 4 046-222 11 26 bk@jur.lu.se www.jur.lu.se/utbildning/fristaende-kurser 221 00 Lund 222 22 Lund Kursutvärdering för Barnkonventionen ur ett svenskt perspektiv, [JBKA01], HT25 Kursansvarig: Kristian Gustafsson Övriga lärare: Johanna Bentelius, Tova Jangenfeldt, Laura Möller Andréewitch, Cornel
https://www.jur.lu.se/sites/jur.lu.se/files/2026-03/Kursutv%C3%A4rdering%20JBKA01%20HT25.pdf - 2026-07-08
