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ObjectiveComputerized decision‐support tools may improve diagnosis of acute myocardial infarction (AMI) among patients presenting with chest pain at the emergency department (ED). The primary aim was to assess the predictive accuracy of machine learning algorithms based on paired high‐sensitivity cardiac troponin T (hs‐cTnT) concentrations with varying sampling times, age, and sex in order to rule

Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have

OBJECTIVES: Early diagnostic separation between glioblastoma (GBM) and solitary metastases (MET) is important for patient management but remains challenging when based on imaging only. The objective of this study was to assess whether amide proton transfer weighted (APTw) MRI alone or combined with dynamic susceptibility contrast (DSC) MRI parameters, including cerebral blood volume (CBV), cerebra

Iron-centered N-heterocyclic carbene compounds have attracted much attention in recent years due to their long-lived excited states with charge transfer (CT) character. Understanding the orbital interactions between the metal and ligand orbitals is of great importance for the rational tuning of the transition metal compound properties, e.g., for future photovoltaic and photocatalytic applications.

Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM

Rapporten sammanfattar fjärilsinventeringar utförda 2022 inom Biogeografisk uppföljning som drivs av Naturvårdsverket. I fjällområdet kunde totalt 35 ytor inventeras. Sammanlagt noterades 38 högnordiska blåvingar på 12 av 16 inventerade ytor, 34 dvärgpärlemorfjärilar på 14 av 17 ytor och 3 fjällsilversmygare noterades på 2 av 3 inventerade ytor. Svartfläckig blåvinge observerades på 23 av 56 inven

This article examines the emergence of idealism in evolutionary cognitive science by analyzing the conscious realism of the cognitive theorist Donald D. Hoffman and the mathematician Chetan Prakash. Perception is for them not about veridical experience, but rather a mechanism for survival. It helps us survive but does not give us access to reality as such. By relating Hoffman and Prakash's conscio

A naturalistic view should make us appreciate the rich possibilities of nature. This naturalistic point of departure, as formulated by Willem B. Drees, invites reflection on the relationship between nature and spirituality. Today, the concept of sustainability occupies a key role in what has come to be the greatest challenge ever that humankind has faced together at the same moment in history. Usu

Focusing on three initiatives of the United Nations Framework Convention on Climate Change (UNFCCC) Secretariat – the Momentum for Change Initiative, the Lima–Paris Action Agenda, and the Non-state Actor Zone for Climate Action – this chapter studies how an international environmental bureaucracy can evolve from a low-key and servant-like secretariat to an actor in its own right. It argues that in

Recent technologies of district heating and cooling (DHC) systems integrate renewable energy sources and connect multiple heat producers and consumers to the same network. The resulting interactions may therefore cause the fluid in the pipe, or the energy carried by the system, to flow in both directions. This article presents a newly developed analytical method for evaluating the hydraulic states