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Palliative sedation via intraosseous vascular access : A safe and feasible way to obtain a vascular access end of life

Intraosseous (IO) access is normally reserved for emergencies and critical care conditions when venous cannulation is not possible. Nonetheless, we present a case of IO insertion to a 56-year-old man, tetraplegic for many years due to progressive spinal muscular atrophy and with refractory suffering. The IO access was used for palliative sedation with propofol in a home care setting. The patient d

Methods and principles of product design for small-scale production based on 3D printing

Technology of 3D printing is opening the possibility for small-scale production in quantities between ten and several hundred pieces. The technology of adding material enables the production of complex and integrated functional concepts in a single-pass process, which consequently potentially reduces the need for assembly operations. Design approaches and manufacturing processing are not mastered

Investigation of the fetal heart circulation in an animal model using contrast enhanced ultrasound

To assess the distribution of blood from the umbilical vein (UMV), inferior vena cava (IVC) and superior vena cava (SVC) to either side of the fetal lamb heart by using ultrasound enhanced contrast agent imaging. By injection of ultrasound contrast agents (UCA) in UMV, IVC or SVC, the blood from these vessels was tracked, as it then was highly echogenic. By evaluating the image intensity within th

Frost-induced deterioration of concrete in hydraulic structures : Interactions between water absorption, leaching and frost action

Frostnedbrytning av betong kan få allvarliga konsekvenser för en konstruktions säkerhet, beständighet och funktionsduglighet eftersom betongens hållfasthet försämras. Frostskador uppstår vanligtvis i konstruktioner med hög fuktbelastning och som periodvis utsätts för frostangrepp. Olika typer av betongskador, vilka kan misstänkas vara frostrelaterade, har påträffats i svenska vattenkraftsanläggninFrost deterioration of concrete can result in severe consequences to the safety, durability and functionality of a structure since it impairs the strength of the concrete. Frost damage may occur to structures that are in contact with water and subjected to frost action. Different types of concrete damage, which are suspected to be frost related, have been observed in concrete structures in Swedish

Characterization of Subscriber Local Loop by Measures and Analysis of Frequency and Impulse Responses

This paper presents methodologies that could be used for characterizing subscriber telephone loops that carry DSL services (ADSL and ADSL2+), by determination and analysis of frequency response, time domain reflectometry, and impulse response of the line. From this analysis, the subscriber loop length, identification and location of impairments such as bridged taps, gauge changes, and open ended t

Learning on Demand in GIS - Challenges for Employers and Universities

Summary – 200 words In education today, there is a paradigm shift with critical challenges for Universities to enhance innovation in teaching and learning. Knowledge and learning are critical issues for most companies and private and civil service organizations with today’s rapid changes in socio-economy and technology. The needs for competence development vary along a broad scale from short info

A Proposal for Improving Project Coordination using Data Mining and Proximity Tracking

Coordination is an important success factor for a development project. Communication gaps, e.g. between product owners shaping the requirements and testers verifying the developed software can result in wasted effort and unsuccessful products. We propose improving the communication between project members with recommendations of whom to interact with and what to discuss based on link prediction in

Environmental barriers and use of mobility devices.

To describe outdoor barriers in the nearby home environments of very old people, and to investigate whether the presence of these environmental barriers differed between users and non-users of mobility devices (MDs). Method: Baseline data on 397 Swedish people aged 80-89 years, collected with a study-specific question on MD use and a subset of the environmental component of the Housing Enabler ins

Measuring spatial patterns in floodplains : A step towards understanding the complexity of floodplain ecosystems

This chapter focuses on measuring spatial pattern in floodplains and reviews 108 publications from 1934-2013 to determine trends, dominant paradigms, and approaches to measuring spatial pattern in floodplains. The development of new technologies, especially those associated with remotely sensed data capture, increases the ability to quantitatively measure the spatial complexity of floodplain surfa

Psychosocial Well-Being of Young People Who Participated in a Support Group Following the Loss of a Parent to Cancer

Despite the evidence of unmet support needs among young people who have lost a parent to cancer, only a few support group initiatives have been reported. This observational prospective study explored the psychosocial well-being of young people who participated in support groups at a Swedish specialist palliative care setting. On three occasions, 29 participants, aged 16–28 years, answered question

Diagnostics and treatment of human malignant tumours using laser based techniques

Laser-induced fluorescence is a technique for optical tissue characterisation. It has a real-time capability and as the excitation light and the fluorescence emission are transmitted through optical fibres the technique is compatible to various kinds of endoscopes for hollow organ investigation. The tissue fluorescence itself with the emission from the endogenous chromophores or enhanced with exog

Products, Performance, and Technological Development of Ambulatory Oxygen Therapy Devices : Scoping Review

Background: Ambulatory oxygen therapy is prescribed for patients with chronic lung diseases who experience exertional hypoxemia. However, available devices may not adequately meet user requirements, and their performance characteristics are heterogeneous. Objective: This study aims to identify devices available for delivery of ambulatory oxygen therapy, the technologies that they use to generate o

The ALLAN trial: impact of early home-based palliative care on emergency care and hospitalisation in advanced gastrointestinal cancer patients

Bakgrund: Patienter med avancerad gastrointestinal (GI) cancer har en hög symtombörda, vilket ofta medför behov av akutsjukvård. Integration av tidig, hem-baserad specialiserad palliativ vård (SPV) tillsammans med tumörspecifik behandling kan påverka behov av akut sjukvård.Metoder: Vid initiering av palliativ kemoterapi randomiserades patienter med avancerad GI-cancer till tidig hem-baserad SPV inBackgroundPatients with advanced gastrointestinal (GI) cancer experience a high symptom burden which frequently necessitates emergency care. Integration of early home-based specialised palliative care (SPC) with tumour-specific treatments may impact emergency healthcare use.MethodsAt the initiation of palliative chemotherapy, patients with advanced GI cancer were randomised to early home-based SPC

WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene.

The Kruppel-like protein ZNF224 is a co-factor of the Wilms' tumor 1 protein, WT1. We have previously shown that ZNF224 exerts a specific proapoptotic role in chronic myelogenous leukemia (CML) K562 cells and contributes to cytosine arabinoside-induced apoptosis, by modulating WT1-dependent transcription of apoptotic genes. Here we demonstrate that ZNF224 gene expression is down-regulated both in