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BackgroundThere is a need for the development of accurate, accessible and efficient screening instruments, focused on early-stage detection of neurocognitive disorders. The Geras Solutions cognitive test (GSCT) has showed potential as a digital screening tool for cognitive impairment but normative data are needed.ObjectiveThe aim of this study was to obtain normative data for the GSCT in cognitive
Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cell
During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role. Previous studies have mostly utilized 4-aminopyridine to induce epileptiform discharges in brain slices from healthy animals. However, it is not clear if the seizure-triggering ability of parvalbumin-interneurons also holds true without the use of external conv
AI cancer detection models require calibration to attain the desired balance between cancer detection rate (CDR) and false positive rate. In this study, we simulate the impact of six types of mismatches between the calibration population and the clinical target population, by creating purposefully non-representative datasets to calibrate AI for clinical settings. Mismatching the acquisition year b
In this paper we show that OpenAI’s Large Language Model (LLM) GPT perform remarkably well when used for title and abstract eligibility screening of scientific articles and within a (systematic) literature review workflow. We evaluated GPT on screening data from a systematic review study on electric vehicle charging infrastructure demand with almost 12,000 records using the same eligibility criter
Global policies, legislation, and eco-friendly initiatives have induced the steel industry to integrate sustainable development approaches. Sustainability requires all phases from raw material sourcing to transportation to waste and carbon footprint elimination—yielding positive effects. This research employs a two-step approach in sustainability. The first phase entails conducting a systematic li
The delay between the origin of animals in the Neoproterozoic and their Cambrian diversification remains perplexing. Animal diversification mirrors an expansion in marine shelf area under a greenhouse climate, though the extent to which these environmental conditions directly influenced physiology and early organismal ecology remains unclear. Here, we use a biogeochemical model to quantify oxygen
Key questions for understanding hippocampal function in memory and navigation in humans are the type and source of visual information that reaches the human hippocampus. We measured bidirectional pairwise effective connectivity with functional magnetic resonance imaging between 360 cortical regions while 956 Human Connectome Project participants viewed scenes, faces, tools, or body parts. We devel
INTRODUCTION: We evaluated differences in p-tau levels between Alzheimer's disease (AD), a condition with brain-specific changes in p-tau, and amyotrophic lateral sclerosis (ALS), a condition associated with increases in peripheral p-tau levels. METHODS: Cerebrospinal fluid and plasma from 668 participants were analyzed using immunoassays specific for the low-molecular-weight (LMW) tau isoforms pr
Naturvetenskap, teknik, ingenjörsvetenskap och matematik, på engelska ofta grupperade under akronymen STEM, är traditionellt mansdominerade områden. Särskilt inom ingenjörsvetenskap och teknologi är kvinnor fortfarande kraftigt underrepresenterade. Bristen på kvinnor inom STEM innebär utmaningar i att möta arbetsmarknadens behov, för produktkvalitet på grund av brist på olika perspektiv i designprScience, technology, engineering and mathematics, often grouped under the acronym STEM, are traditionally male dominated fields. Especially in engineering and technology, women continue to be heavily underrepresented. The lack of women in STEM poses challenges for meeting the labor market demands, for product quality due to a lack of diverse perspectives in the design process, and for gender equal
How we teach is strongly influenced by the culture we teach in, especially what (we believe) our colleagues think is good and acceptable. Understanding the reluctance to changes in teaching practice, including fear of disapproval from colleagues and students, investigating and reappraising those fears, and starting to talk about alternative interpretations is a first step towards overcoming the in
Precise knowledge of the temperature during cutting processes is of high interest as the temperature of a cutting tool dictates the performance, and for the workpiece it controls the quality and integrity of the generated surface. For the first time, in this study, a novel technique has been developed utilizing phosphor thermometry for 2D surface temperature measurement of a cutting tool in metal
BACKGROUND: Low back pain (LBP) is a leading cause of work absence globally. Digital interventions have the potential to increase access to self-management support for individuals with persistent LBP.OBJECTIVE: This study aims to evaluate the feasibility, usability, and acceptability of a digital educational program (MyRelief) designed to support self-management strategies for people with persiste
Introduction: Most cervical cancer cases in Sweden are diagnosed among women who have failed to attend screening. The objective of this study was to analyze the effectiveness of offering vaginal HPV (human papillomavirus) self-samples to long-term non-attendees as a routine in this screening program, in which non-attendees had already been the targets of several interventions. Material and Methods
The Middle Darriwilian Isotopic Carbon Excursion (MDICE) is one of the globally recognized positive excursions in carbon isotope chemostratigraphy, but mainly documented by δ13Ccarb data in previous research. In this paper, new stable organic carbon isotope data (δ13Corg) are presented from the Hule-1 core from the southern Anhui Province of southern China. The core constitutes an Ordovician silic
BACKGROUNDDistinguishing wide complex tachycardia (WCT) as ventricular tachycardia (VT) or supraventricular WCT (SWCT) is critical yet challenging. Manual ECG algorithms require substantial expertise and are inconsistently applied, and contemporary computerized ECG interpretation (CEI) systems often return only a generic “wide complex tachycardia” label. Novel machine learning–based ECG models (So
The rapid progression of the electrification of road transport in many countries urges the need to make informed decisions on the location and size of the required charging infrastructure. This paper’s main contribution is a novel method to position fast-charging stations based on the transportation energy demand and to evaluate the performance of such charging infrastructure. Depending on their r
Background. National registries that capture patients with chronic kidney disease (CKD) across all stages are scarce. We present here the Swedish Renal Registry (SRR), a nationwide prospective register covering the whole spectrum of CKD. Methods. Created in 1991, SRR enrolls CKD patients referred to adult nephrologist care (non-dialysis CKD [ND-CKD], kidney transplantation, maintenance dialysis),
The recognition of amine groups by ninhydrin, along with a simple mathematical algorithm, showed that di- and tripeptides derived from dietary protein are the major end products of protein digestion entering the blood postprandially. There are thousands of oligopeptides appearing in the gut during protein digestion. However, the presented study on a pig model clearly shows that peptides longer tha
