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Objective. To evaluate the longitudinal development of the tricuspid gradient (TG) for screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Methods. Doppler echocardiography was performed 506 times in order to estimate TG in 227 consecutive patients with SSc. The value of biochemical markers for predicting TG levels and development was assessed through analyses of pro-b
Traumatic brain injury (TBI) is an established risk factor for neurodegenerative disorders and dementias. Epigenetic modifications, such as DNA methylation, may alter the expression of genes without altering the DNA sequence in response to environmental factors. We hypothesized that DNA methylation changes may occur in the injured human brain and be implicated in the neurodegenerative aftermath of
The present study focuses on introducing the concept of optimisation and proposing a model, including evaluation of image quality, to be used in the clinical routines where image-guided intervention is being performed. The overall aim of the study was to develop a model for evaluating the use of imaging in X-ray-guided interventional procedures and its possible implications on optimisation of radi
The Jk(a-b-) phenotype results from alterations in the JK gene and is characterized by absence of the RBC urea transporter in the cell membrane. The frequency of Jk(a-b-) varies among populations, but this phenotype is most commonly found in people of Polynesian and Finnish descent. Although rare, Jk(a-b-) individuals present a clinical challenge because anti-Jk3 is produced readily in response to
Here, we present a revised protocol to derive neuroepithelial stem (NES) cells from human induced pluripotent stem cells. NES cells can be further differentiated into a culture of neurons (90%) and glia (10%). We describe how to derive and maintain NES cells in culture and how to differentiate them. In addition, we show the potential use of NES cells to study the role of reactive oxygen species in
In 2018, a strategy for Sweden's first National Forest Program was launched. As part of its implementation, County Administrative Boards have initiated dialogue processes for drafting regional forest strategies. Stakeholder deliberation is ascribed the potential to promote trust and mutual understanding, lead to more robust decisions and smoother implementation. We examine the dialogue processes,
Parkinson’s disease is predominantly a dopamine deficiency syndrome, which is produced in the brain by the loss of cells located in a small area in the ventral midbrain called the substantia nigra. Complete unilateral dopamine lesions, based on the administration of toxic substances (ie, 6-hydroxy-dopamine in rats and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice and primates) have been ext
The Swedish Knee Arthroplasty Registry (SKAR) has recorded knee arthroplasties prospectively in Sweden since 1975. The only outcome measure available to date has been revision status. While questionnaires on health outcome may function as more comprehensive endpoints, it is unclear which are the most appropriate. We tested various outcome questionnaires in order to determine which is the best for
BACKGROUND: The objective of this study was to investigate the relationship between history of induced abortion and preterm delivery in various parts of Europe, and according to the main cause of preterm birth. METHODS: We used data from a case–control survey, the EUROPOP study; 2938 preterm births and 4781 controls at term from ten European countries were included. Based on national statistics, w
Patients with an implantable cardioverter defibrillator (ICD) have an ongoing risk of sudden incapacitation that might cause harm to others while driving a car. Driving restrictions vary across different countries in Europe. The most recent recommendations for driving of ICD patients in Europe were published in 1997 and focused mainly on patients implanted for secondary prevention. In recent years
The release of toxic gases due to natural/industrial accidents or terrorist attacks in populated areas can have tragic consequences. To prevent and evaluate the effects of these disasters different approaches and modelling tools have been introduced in the literature. These instruments are valuable tools for risk managers doing risk assessment of threatened areas. Despite the significant improveme
© 2017 Metal cutting simulations have become an important part of cutting tool design and the research in the field in general. One of the most important aspects of modeling is the accuracy of the tool geometry. 3D microscopy is used for measuring the tool edge radius with good accuracy. However, especially with sharp tools, i.e. small tool edge radii, the measurements, no matter how accurate, are
This study aims to examine how local governments originated from the global South, through Urban Food System Strategies (UFSS), are realizing global sustainability priorities as outlined by the Sustainable Development Goals (SDGs). This study is based on the policy analysis of three Latin American UFSS, with the aim to detect synergies and connections between the UFSS and the SDGs. The primary c
Party polarization research at the academic level has been limited so far compared to media coverage. Nonetheless, there is increasing academic attention on the effects of polarization on policy intensity. This study aims to analyse the impact party polarization has on the government response carried out in the EU countries during Covid-19. The specialized literature study how political polarizati
How does anti-tourism affect support for the EU? This question has gained a newly found relevance in recent years, as anti-tourism protests have appeared in many European cities with high levels of tourism. Despite this relevance, some elements of these protests have not received as much attention as they deserve. This thesis will aim to fill one of the gaps in the literature: how anti-tourism soc
Conventional agriculture and animal husbandry are leading causes of greenhouse gas emissions,environmental degradation, and biodiversity loss. Biocyclic Vegan Agriculture (BVA) is an approach that aims to address the concerns of modern agriculture and provide a sustainable and ethical alternative. Through the heuristic lens of the Multi-Level Perspective, where BVA serves as a potential niche, thi
This thesis presents an application of machine learning techniques in a search for a high-mass resonance particle decaying into top quark pairs in high energy dijet events using the ATLAS experiment at the Large Hadron Collider. Top tagging is applied to the dijet events to select the events with top signature and suppress the background, increasing the sensitivity of the search. All the data used
Following the UNHCR:s launch of the #IBelong Campaign to End Statelessness by 2024 in November 2014, a Global Action Plan to End Statelessness: 2014 – 2024 was adopted urging states to undertake ten actions to end statelessness, including to facilitate the naturalization of stateless migrants. While the facilitated naturalization of stateless persons would certainly reduce the occurrence of statel
