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Background: The Bone Scan Index (BSI) is used to quantitatively assess the total tumour burden in bone scans of patients with metastatic prostate cancer. The clinical utility of BSI has recently been validated as a prognostic imaging biomarker. However, the clinical utility of the on-treatment change in BSI is dependent on the reproducibility of bone scans. The objective of this prospective study
A search for highly ionizing particles produced in proton-proton collisions at 8 TeV center-of-mass energy is performed by the ATLAS Collaboration at the CERN Large Hadron Collider. The data set used corresponds to an integrated luminosity of 7.0 fb-1. A customized trigger significantly increases the sensitivity, permitting a search for such particles with charges and energies beyond what was prev
This Letter describes a model-agnostic search for pairs of jets (dijets) produced by resonant and non-resonant phenomena beyond the Standard Model in 3.6 fb−1 of proton–proton collisions with a centre-of-mass energy of s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. The distribution of the invariant mass of the two leading jets is examined for local excesses above a data-deri
Higgsinos with masses near the electroweak scale can solve the hierarchy problem and provide a dark matter candidate, while detecting them at the LHC remains challenging if their mass splitting is O(1 GeV). This Letter presents a novel search for nearly mass-degenerate Higgsinos in events with an energetic jet, missing transverse momentum, and a low-momentum track with a significant transverse im
The sector for private domestic services in Sweden has grown rapidly since the RUT tax deduction was introduced in 2007. Already in the government proposition (2006/07:94) it was suggested that services provided by the expanding market would come to replace parts of the publicly funded elderly care, thus marking a shift in the organisation of care in the welfare state. Today we begin to see the ef
Tissue factor (TF)-mediated protease activated receptor (PAR)-2 signaling is associated with a pro-migratory, invasive and pro-angiogenic phenotype in experimental models of breast cancer, and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these findings are unknown. Here, we provide first in vivo evidence of TF phosphoryl
The Lecanoromycetes is the largest class of lichenized Fungi, and one of the most species-rich classes in the kingdom. Here we provide a multigene phylogenetic synthesis (using three ribosomal RNA-coding and two protein-coding genes) of the Lecanoromycetes based on 635 newly generated and 3307 publicly available sequences representing 1139 taxa, 317 genera, 66 families, 17 orders and five subclass
An accurate molecular diagnosis of diabetes subtype confers clinical benefits; however, many individuals with monogenic diabetes remain undiagnosed. Biomarkers could help to prioritise patients for genetic investigation. We recently demonstrated that high-sensitivity C-reactive protein (hsCRP) levels are lower in UK patients with hepatocyte nuclear factor 1 alpha (HNF1A)-MODY than in other diabete
Purpose. The overall purpose was to study whether and how persons with blindness detect warning surfaces with a long white cane in a real pedestrian environment after following a natural guidance surface to the warning surfaces. Of particular interest was the importance of kerb, depth, and structure of the warning surfaces. Method. A concurrently mixed methods approach, with a combination of obser
This Letter presents a search for pair production of heavy down-type quarks decaying via b' -> Wt in the lepton + jets channel, as b'(b) over bar' -> W(-)tW(+)(t) over bar -> b (b) over barW(+)W(-)W(+)W- -> l(+/-) nu b (b) over barq (q) over barq (q) over barq ($) over barq. In addition to requiring exactly one lepton, large missing transverse momentum, and at least six jets, the invariant mass of
In a previous experimental study, a novel method for in vivo dosimetry has been investigated, based on radioluminescence (RL) and optically stimulated luminescence (OSL). However, because of (fie large difference in atomic composition between the detector material and the breast tissue, relatively large energy dependence in low-energy X-ray beams can be expected. In the present work, the energy de
Continues positive airway pressure (CPAP) is recommended for treatment of sleep apnoea (SA) in patients with congestive heart failure (CHF) but is not easily tolerated resulting in poor patient compliance. Mandibular advancement device (MAD) is designed to inhibit pharyngeal airway (PAW) obstruction and may be a valuable alternative. It has been proposed that MAD exerts its effect by increasing PA
Differential and double-differential distributions of kinematic variables of leptons from decays of top-quark pairs (tt¯) are measured using the full LHC Run 2 data sample collected with the ATLAS detector. The data were collected at a pp collision energy of s = 13 TeV and correspond to an integrated luminosity of 140 fb −1. The measurements use events containing an oppositely charged eμ pair and
Currently, many Global South countries face an unprecedented debt crisis with large portions of their spending going to debt repayments. This financial restrain hinders their capacity to address basic needs and ecological challenges, particularly as climate change exacerbates vulnerabilities. To provide a solution for this, The Nature Conservancy (TNC) launched their Nature Bonds Program aimed at
The discussion of human activities exploiting natural resources and their environmental impact has gained more traction throughout the past decade. Especially the role corporations play in these developments has caused a shift within corporate strategic considerations. As a result, today, many companies assume increasing responsibility to improve their sustainability performance. Large, internatio
The Brundtland report envisioned three sustainable dimensions for development: economic growth, ecological balance, and social inclusion with the aim to incorporate these dimensions into local, national, and global plans for sustainable development. In recent years, discussions about our society’s competitiveness and whether the three dimensions of sustainable development include all aspects of ou
Research aim: The thesis aims to research how higher education professionals perceive internal communication as a mean for knowledge-sharing within their workplace, and how it can support organizational learning. Theoretical framework and literature review: The theoretical framework applied, address and discuss the connection between internal communication, organizational learning, single- and do
Formerly widely distributed throughout Europe, the great snipe (Gallinago media) – a medium-sized wader species – has experienced an important decline in the last century, mainly driven by habitat loss. Remaining population are now restricted to eastern Europe and Scandinavia and the species is considered endangered. The great snipe (Gallinago media) is a food specialist, feeding almost exclusivel
Médecins Sans Frontières (MSF) does currently not have dedicated decision-making support for their in-country inventory allocation and is exploring how such decision support framework could be designed to enhance their supply chain operations. The purpose of this thesis is thus to develop a structured framework for country-level inventory allocation decision-making at MSF.To fulfil the purpose t
