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Integrated pest management (IPM) is an important tool for sustainable crop production. IPM includes a diversity of methods, e.g., the use of biological control agents (BCAs) for disease control or growth promotion. While there is an increasing interest in the use of BCAs, less is known about their environmental costs and benefits on wild species, such as wild crop relatives. For example, a BCA may
The amyloid precursor protein intracellular domain (AICD), a cleavage product of amyloid precursor protein implicated in Alzheimer disease and amyloid lateral sclerosis, is a functionally important but structurally elusive intrinsically disordered protein. In this study, we investigate the conformational ensemble of a 35-residue AICD segment encompassing the conserved YENPTY motif using molecular
Background: Metformin is one of the most used drugs worldwide. Given the increasing use of proteomics in trials, bioresources, and clinics, it is crucial to understand the influence of metformin on the levels of the circulating proteome. Methods: We analysed a combined longitudinal proteomics dataset from the IMPOCT, RAMP and S3WP-T2D clinical trials in 98 participants before and after metformin e
BACKGROUND AND OBJECTIVES: Iron deficiency anaemia is common in patients recovering from major surgery and is associated with poorer post-operative outcomes. We designed a randomized controlled trial treating post-operative anaemia with iron therapy to observe the influence on post-operative recovery.MATERIALS AND METHODS: Anaemic patients (haemoglobin [Hb] < 120 g/L for women, Hb < 130 g/L for me
Bacteriophages must overcome diverse bacterial immune systems, yet the molecular principles enabling such escape remain poorly understood. Here, we show that the phage homing endonuclease SegB facilitates immune evasion by promoting the segmental amplification of anti-defense loci. The antiphage defense Septu inhibits phage T6 replication by cleaving the variable loop of tRNATyr. We show that SegB
Background: Limited evidence exists for effect modification of genetic characteristics on the associations of food consumption and incident type 2 diabetes (T2D). Objectives: We aimed to investigate whether the food-T2D association would vary by genetic susceptibility to metabolic traits. Methods: We analyzed data from 9542 incident T2D cases and a subcohort of 12,477 participants nested within th
BACKGROUND: Previously considered rare, penicillin-susceptible Staphylococcus aureus (PSSA) bacteraemia has re-emerged worldwide. Although benzylpenicillin might offer advantages in terms of pharmacokinetic and adverse effect profiles, anti-staphylococcal penicillins are recommended for serious infections because of concern over undetected penicillin resistance. We aimed to compare benzylpenicilli
Strategies to claim Dalit human rights in Tamil Nadu, India This thesis analyzes interviews and ethnographic accounts from the Indian non-governmental organization (NGO) Equity Justice which works with Dalit human rights in Tamil Nadu. It examines the strategies by the NGO since many Dalits usually lacks knowledge about their rights and how they can be claimed. The main subjects are discrimination
The nucleotide sequences of the variable region genes encoding five different human, high affinity antibodies, specific for the major neutralization determinant (AD-1) expressed by human cytomegalovirus glycoprotein B (gp58/116), have been determined. Three of the five heavy chain variable regions belonged to the small VHV-family, although they combined with a diverse set of light chains (V kappa
Popular Abstract in Swedish Denna avhandling utgöres av två separata rapporter, där studieobjektet för den första är en vektorvärd Sturm-Liouville ekvation på formen -(PU')'+QU=zU, xin[0,b), med P^{-1},W,Q hermiteska med lokalt integrerbara matriselement; och under vissa ytterligare villkor på P^{-1} och W. Under dessa förutsättningar härleds några huvudresultat beträf- fande asymptotiken, då z igThis discourse is constituted by two separate reprots, where the first one offers an elementary deduction of the leading order term asymptotics for the Titchmarsh-Weyl M-function corresponding to a vector-valued Sturm-Liouville equation of the form -(PU')'+QU=zu, xin[0,b), with P^{-1},W,Q being hermitean with locally integrable entries; and under some additional conditions on P^{-1} and W. In the
The literature identifies two forms of business organization, Neocorporatist and firm-level, and the strength of each respective type has changed over time; whereas Neocorporatism has remained steady or declined, firm-level organization has become stronger in all countries. The literature underscores the differential effects of these two forms of business organization on employer support for activ
BACKGROUND: Few earlier studies have analysed smoking as a risk factor for myocardial infarction (MI) or stroke in type 2 diabetic patients. DESIGN AND METHODS: A longitudinal study involved 13 087 female and male patients with type 2 diabetes from the Swedish National Diabetes Register with no previous MI or stroke at baseline, aged 30-74 years, and with data available for all analysed variables,
The PrsA protein of Bacillus subtilis is an essential membrane-bound lipoprotein that is assumed to assist post-translocational folding of exported proteins and stabilize them in the compartment between the cytoplasmic membrane and cell wall. This folding activity is consistent with the homology of a segment of PrsA with parvulin-type peptidyl-prolyl cis/trans isomerases (PPIase). In this study, m
Because of the inexact nature of visual classification schemes and the resulting uncertainties of specifying raw material origins, geochemical methods applicable for sourcing Scandinavian flint have been sought. The authors have shown that EDXRF analysis yields geochemical data sufficiently precise and accurate to discriminate among many different varieties of archaeologically significant flint. H
For pt.III see J. Math. Phys., vol.28, p.260 (1987). The one-dimensional inverse scattering problem is considered for lossy inhomogeneous media for the case in which the phase velocities at the two boundaries of the scatterer do not match that of the host medium. The model problem involves electromagnetic wave propagation in a medium of unknown thickness with spatially varying permittivity and con
he study purpose is to determine whether numeric and/or graphic ST measurements added to the display of the 12-lead electrocardiogram (ECG) would influence cardiologists' decision to provide myocardial reperfusion therapy. Twenty ECGs with borderline ST-segment deviation during elective percutaneous coronary intervention and 10 controls before balloon inflation were included. Only 5 of the 20 ECGs
Abstract We present a practical protocol for the assignment of values to serum proteins in a Target Material using a Reference Material. This protocol is based on the model of Direct Value Transfer between serum matrices and is intended to improve the value assignment of commercial calibrators using the Reference Material CRM 470 (now labeled ERM-DA 470) or similar reference materials. The procedu
Abstract Aim: To investigate the risk of small for gestational age (SGA) births in relation to maternal history of cardiovascular disease (CVD) across two generations and additionally to analyse maternal CVD risk based on number of SGA offspring. Methods: We used register data from 1.4 million women and 2.7 million offspring. The outcome measures were risk of being SGA in relation to maternal tota
Duchenne muscular dystrophy (DMD) is the most common childhood myopathy, characterized by muscle loss and cardiorespiratory failure. While the genetic basis of DMD is well established, secondary mechanisms associated with dystrophic pathophysiology are not fully clarified yet. In order to obtain new insights into the molecular mechanisms of muscle dystrophy during earlier stages of the disease, we
Background and purpose Hemiarthroplasty as treatment for femoral neck fractures has increased markedly in Sweden during the last decade. In this prospective observational study, we wanted to identify risk factors for reoperation in modular hemiarthroplasties and to evaluate mortality in this patient group. Patients and methods We assessed 23,509 procedures from the Swedish Hip Arthroplasty Registe
