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Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 stool BAs in two population-based cohorts (TwinsUK, n = 2,382; ZOE PREDICT-1, n = 327) and assess changes post-bariatric surgery and after nutritional
Objectives: Genome-wide association studies have revealed over 200 genetic susceptibility loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be generated to predict risk of PCa. We summarize the published evidence and conduct meta-analyses of PRS as a predictor of PCa risk in Caucasian men. Patients and methods: Data were extracted from 59 studies, with 16 studies i
Many-electron systems undergo a collective Larmor precession in the presence of a magnetic field. In a paramagnetic metal, the resulting spin wave provides insight into the correlation effects generated by the electron-electron interaction. Here, we use dynamical mean-field theory to investigate the collective Larmor precession in the strongly correlated regime, where dynamical correlation effects
The extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters afte
A search for the electroweak production of pairs of charged sleptons or charginos decaying into two-lepton final states with missing transverse momentum is presented. Two simplified models of R-parity-conserving supersymmetry are considered: direct pair-production of sleptons (ℓ~ ℓ~) , with each decaying into a charged lepton and a χ~10 neutralino, and direct pair-production of the lightest chargi
Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and
Background: Adverse events induced by intravesical bacillus Calmette-Guérin (BCG) to treat high-grade non–muscle-invasive bladder cancer (NMIBC) often lead to treatment discontinuation. The EAU-RF NIMBUS trial found a reduced number of standard-dose BCG instillations to be inferior with the standard regimen. Nonetheless, it remains important to evaluate whether patients in the reduced BCG treatmen
Background: Whether disease burden in patients with metastatic castration-sensitive prostate cancer (mCSPC) predicts treatment outcomes is unknown. We assessed apalutamide treatment effect in TITAN patients with mCSPC by disease volume, metastasis number and timing of metastasis presentation. Methods: These protocol-defined and post hoc analyses of the phase III randomised TITAN study evaluated cl
Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful, disease classification can become complex and limit advances in research and medical care. Here, we describe diabetes heterogeneity, highlighting recent approaches that could facilitate management by integrating three d
Prediabetes is a metabolic condition associated with gut mi-crobiome composition, although mechanisms remain elu-sive. We searched for fecal metabolites, a readout of gut microbiome function, associated with impaired fasting glucose (IFG) in 142 individuals with IFG and 1,105 healthy individuals from the UK Adult Twin Registry (TwinsUK). We used the Cooperative Health Research in the Region of Aug
Worldwide, racial and ethnic minorities have been disproportionately impacted by COVID-19 with increased risk of infection, its related complications, and death. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy may result in differences in uptake. We performed a cohort study among U.S. and U.K. participants who volunteere
The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the av
Background Bothgenetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study was to examine the joint associations of genetic risk and diet quality with incident type 2 diabetes. Methods and findings We analyzed data from 35,759 men and women in the United States participating in the
Objective: Differences in outcome after radical prostatectomy for prostate cancer can partly be explained by intersurgeon differences, where degree of experience is one important aspect. This study aims to define the learning curve of robot-assisted laparoscopic prostatectomy (RALP) regarding oncological and functional outcomes. Materials and methods: Out of 4003 enrolled patients in the LAPPRO tr
EBSCO Discovery Service for Academic | discovery.ebsco.com1 Linking Workshop Wednesday, 3rd Apil 2019 | discovery.ebsco.com2 Introduction • Adam Walsh • Manager, Library Services Engineering - North, Central, East & South-East Europe • awalsh@ebsco.com mailto:awalsh@ebsco.com | discovery.ebsco.com3 Agenda • Linking Admin Overview • Examples • Additional Questions | discovery.ebsco.com4 EBSCOadmin:
https://www.ub.lu.se/sites/ub.lu.se/files/how_to_manage_linking_for_eds_-_presentation_av_adam_walsh_2019-04-03.pdf - 2026-07-08
LU-template English 16:9 Faculty of Science Lund university 1 A world-class university that works to understand, explain and improve our world and the human condition. Lund University vision 2 Faculty of Science 6 departments and one centre Around 1 000 employees Approx. 4000 students (1 800 full-time equivalents) Bachelor’s programme with 12 specialisations (3 in English) The hospital physics pro
https://www.science.lu.se/internal/sites/science.lu.se.internal/files/2026-03/faculty-of-science-2026_0.pptx - 2026-07-08
Skyddsombud - varmt välkomna till oss i Samordningsgruppen! 2025-02-26 Presentation av Samordningsgruppens pågående arbete med leveransmålen i delprojektet Organisation och styrning Att tänka på: Finns inga beslut. Allt är pågående arbete och diskussion! Vi i Samordningsgruppen är: • Katarina Hedlund • Petter Pilesjö • Anders Scherstén • Yann Clough • Anna Maria Jönsson • Raimund Muscheler • Anna
https://www.naturvetenskap.lu.se/internt/sites/naturvetenskap.lu.se.internt/files/2025-02/Skyddsomb%2026feb25.pdf - 2026-07-08
Microsoft Word - 0. Protokoll PROTOKOLL 1 (3) DATUM 2024-11-13 NUMMER 11 Box 2330, 103 18 Stockholm • Besöksadress: Birger Jarls torg 5 • Telefon: 08-561 66 950 • domarnamnden@dom.se • www.domarnamnden.se Expeditionstid: Måndag-fredag 09.00-15.00 R 2 B Tid Kl. 9.15–11.35 Plats Kammarrätten i Stockholm, sammanträdesrum Bonden Birger Jarls torg 5, Riddarholmen, Stockholm Närvarande Ledamöter Monica
https://www.aclu.lu.se/sites/aclu.lu.se/files/2024-12/11._Domarn%C3%A4mnden_13_november_2024.pdf - 2026-07-08
