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Binding of extracellular matrix molecules by enterococci
The bacterial surfaces of enterococci are not uniform. This fact is confirmed by several studies and by our results when great differences between individual strains with regard to their cell surface hydrophobicity, binding of eight ECM (extracellular matrix) molecules immobilized on latex beads and four selected ECM molecules in microtiter plates were observed. The strains expressing high binding
Biological monitoring of exposure to toluene diisocyanate.
Corneal Involvement in Congenital Aniridia.
PURPOSE:: The purpose of this research is 2-fold. First of all, the level of keratopathy development in patients with congenital aniridia is studied. In addition, a correlation between the effects of ocular surgery on the severity of keratopathy is made. METHODS:: A thorough search for the total number of patients with aniridia in Sweden and Norway was performed. One hundred eighty-one patients we
Did introduction of pneumococcal vaccines in the Netherlands decrease the need for respiratory antibiotics in children? Analysis of 2002 to 2013 data
To estimate the effect of the introduction of the 7- and 10-valentpneumococcal vaccines in 2006 and 2011, respectively in the Netherlands, we assessed respiratory antibiotic use in one to nine year-old children between 2002 and 2013. Seasonal autoregressive integrated moving-average models were applied to estimate the percentage reduction in respiratory antibiotic use. When compared with the pre-v
Neutrophil extracellular traps promote surgery-induced peritoneal carcinosis of metastatic colorectal cancer via modulation of CXCR2 and αv integrin
Introduction: Peritoneal carcinosis (PC) is the third common site of metastatic colorectal cancer which characterized by a very low survival rate. Surgical trauma has been identified as an important factor in the progression of PC, postulated to be caused by the inflammatory response to tissue injury. The mechanism behind tumor metastasis remains poorly understood. However, existing evidence indic
From policy to practice: progress towards data- and code-sharing in ecology and evolution
Data and code are essential for ensuring the credibility of scientific results and facilitating reproducibility, areas in which journal sharing policies play a crucial role. However, in ecology and evolution, we still do not know how widespread data- and code-sharing policies are, how accessible they are, and whether journals support data and code peer review. Here, we first assessed the clarity,
Utvidgat ansvar för kommunfullmäktige - Till vilken grad ska fullmäktige hållas ansvarig?
Bestämmelsen om tjänstefel återfinns i 20 kap. 1 § Brottsbalken vilket innebär att den som vid myndighetsutövning, uppsåtligen eller av oaktsamhet, åsidosätter vad som gäller för uppgiften genom handling eller underlåtenhet kan ställas till svars. Idag omfattas inte de kommunalt förtroendevalda i den högre beslutande förvaltningen av detta ansvar då de besitter ett partiellt ämbetsansvar. Detta paThe regulation on misuse of office can be found in chapter 20 § 1 of the Swedish Penal Code which means that a person who in the exercise of public authority, by act or by commission, intentionally or through carelessness, disregards the duties of his office can be held liable. Today, elected representatives cannot be held accountable for their decisions as they hold a partial responsibility. This
The Role of Inosine-5'-Monophosphate Dehydrogenase in Thiopurine Metabolism in Patients With Inflammatory Bowel Disease.
BACKGROUND:: There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) have been associated with a lower response rate and an increased risk of adverse events. In this study, the role of inosine-5'-monophosphate dehydrogenase (IMPDH) for differences in metabo
The visfatin (PBEF1) G-948T gene polymorphism is associated with increased high-density lipoprotein cholesterol in obese subjects.
The newly discovered adipokine visfatin has been hypothesized to be related to obesity and insulin resistance. In this study, we investigate if the 2 single nucleotide polymorphisms rs4730153 and G-948T are associated with obesity and/or related traits and whether they influence the messenger RNA (mRNA) levels of PBEF1 (originally the abbreviation for pre-B-cell colony-enhancing factor 1) in visce
Psychosocial work conditions, unemployment and health locus of control: A population-based study.
AIMS: To investigate the association between psychosocial work conditions, unemployment and lack of belief in the possibility of influencing one's own health. Design/setting/participants/measurements: The 2000 public health survey in Scania is a cross-sectional postal questionnaire study with a 59% participation rate. In total, 5180 persons aged 18-64 years who belonged to the workforce and the un
Effects of various neuropeptide Y/peptide YY fragments on electrically-evoked contractions of the rat vas deferens
1. The effects of various neuropeptide Y (NPY) and peptide YY (PYY) fragments on electrically-evoked twitches in the rat isolated vas deferens were studied and compared with the effects of full length NPY and PYY. The aim was to identify the shortest NPY/PYY fragments that are capable of suppressing the contractions. 2. NPY (1-36) and C-terminal fragments of NPY (from 11-36 to 22-36) suppressed th
Macromolecular interactions, Consequences on carbohydrate metabolism
Popular Abstract in Swedish Växter får energi att växa till och fortplanta sig genom fotosyntes och cellandning. Vid fotosyntesen använder växterna ljusenergin från solen medan vid cellandningen kolföreningar bryts ner för att frigöra den energi som behövs till olika kemiska processerna i cellen. Enzymer är proteiner som katalyserar dessa kemiska processer. För att omvandla ett utgångsämne (t ex sMost cells are crowded with solutes, enzymes, nucleic acids, structural proteins and membranes. Crowding promotes macromolecular interactions and determines major properties of the cellular environment such as viscosity, diffusion and inhomogeneity. Macromolecular interactions that involve enzymes can affect the kinetic and regulatory properties of these, hence the interactions are part of the met
Long-term follow-up study of low-weight avoidant restrictive food intake disorder compared with childhood-onset anorexia nervosa : Psychiatric and occupational outcome in 56 patients
Objective: To compare long term outcome between childhood-onset Anorexia Nervosa (AN) and low-weight Avoidant/Restrictive Food Intake Disorder (ARFID) in regard to psychiatric diagnoses, social and occupational functioning. Method: A consecutive series of 56 children originally treated for low-weight restrictive eating disorder (ED) were followed up after a mean of 15.9 years. ARFID-diagnoses were
Automatic T2* determination for quantification of iron load in heart and liver : a comparison between automatic inline Maximum Likelihood Estimate and the truncation and offset methods
PURPOSE: To validate ironload T2* by automatic inline Maximum Likelihood Estimate (MLE) with k-space Rician noise correction, against the manual and automated truncation, as well as offset methods, in phantoms and in heart and liver in patients.METHODS: Twenty-five patients and an iron-oxide phantom were scanned at 1.5T using 2 multi-echo gradient-echo sequences. All parameters were identical (vox
8.0% Efficient All-Polymer Solar Cells with High Photovoltage of 1.1 V and Internal Quantum Efficiency near Unity
In very recent years, growing efforts have been devoted to the development of all-polymer solar cells (all-PSCs). One of the advantages of all-PSCs over the fullerene-based PSCs is the versatile design of both donor and acceptor polymers which allows the optimization of energy levels to maximize the open-circuit voltage (Voc). However, there is no successful example of all-PSCs with both high Voc
A retrospective epidemiological study of skin diseases among pediatric population attending a tertiary dermatology referral center in Northern Greece
BACKGROUND: The incidence of skin diseases in children is influenced by hereditary, social, and environmental factors. The objective of this study was to determine the incidence of pediatric dermatoses at a University Hospital in Northern Greece.PATIENTS AND METHODS: We reviewed epidemiologic data of 940 patients, aged 0-18 years, who were referred to the outpatient clinic of a University Hospital
Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years
Glucocorticoid use and factors associated with variability in this use in the Systemic Lupus International Collaborating Clinics Inception Cohort
Objectives. To describe glucocorticoid (GC) use in the SLICC inception cohort and to explore factors associated with GC use. In particular we aimed to assess temporal trends in GC use and to what extent physician-related factors may influence use. Methods. Patients were recruited within 15 months of diagnosis of SLE from 33 centres between 1999 and 2011 and continue to be reviewed annually. Descri
Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures
In addition to its well-known hematopoietic effects, erythropoietin (EPO) also has neuroprotective properties. However, hematopoietic side effects are unwanted for neuroprotection, underlining the need for EPO-like compounds with selective neuroprotective actions. One such compound, devoid of hematopoietic bioactivity, is the chemically modified, EPO-derivative carbamylerythropoietin (CEPO). For c
