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Introduction: Our objective was to evaluate the association of early-pregnancy body mass index (BMI) in women with gestational diabetes mellitus (GDM) with maternal, delivery, and child outcomes, and compare with pregnancies without diabetes in southeastern Sweden, including after a surge of non-European immigration. Material and Methods: A retrospective population-based observational study of all

Digitalisering och sociala medier har förändrat hur konsumenter rör sig genom kundresan. Plattformar som TikTok har bidragit till en mer komplex och icke-linjär kundresa där inspiration, informationssökning, interaktion och konsumtion sker parallellt. Samtidigt har användargenererat innehåll fått ökad betydelse för hur konsumenter värderar information och fattar köpbeslut. Mot denna bakgrund under

OBJECTIVE: To investigate the relationship of hospital admissions due to unexplained syncope and orthostatic hypotension (OH) with subsequent cardiovascular events and mortality.METHODS: We analysed a population-based prospective cohort of 30 528 middle-aged individuals (age 58±8 years; males, 40%). Adjusted Cox regression models were applied to assess the impact of unexplained syncope/OH hospital

Bakgrund: Hur vi identifierar oss är starkt kopplat till arbete. Unga vuxna är en känslig grupp när det gäller inträde på arbetsmarknaden. Om de också har psykisk ohälsa blir det ännu svårare och risken för marginalisering ökar. Likväl har arbete visat väsentlig betydelse för en personlig återhämtning. Syftet med studien var att utforska erfarenheter bland unga vuxna med psykisk ohälsa som börjar

The physiological characteristics of native and bacterial exopolysaccharides (EPS) in oats and barley-based fermented products were studied in relation to the physico-chemical properties. Article I presents a parallel-randomized double blind clinical trial using a dairy-based product (control), an oat-based product (fermented with V2, which is a mixture (1:1) of Lactobacillus delbrueckii subsp. Bu

Background and ObjectivesEEG is widely used for prediction of neurologic outcome after cardiac arrest. To better understand the relationship between EEG and neuronal injury, we explored the association between EEG and neurofilament light (NfL) as a marker of neuroaxonal injury, evaluated whether highly malignant EEG patterns are reflected by high NfL levels, and explored the association of EEG bac

In Sweden 4200 patients are diagnosed with lung cancer and 6500 patients with colorectal cancer (CRC) annually. The lungs are a common site for metastases. Immunohistochemistry (IHC) is a helpful aid in diagnostics of a pulmonary tumour. Selected patients with metastatic CRC undergo pulmonary metastasectomy and knowledge about which patients benefit from it is important. In this thesis IHC markers

BACKGROUND: The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years co

Importance: Hypochondriasis, also known as health anxiety disorder, is a prevalent, yet underdiagnosed psychiatric disorder characterized by persistent preoccupation about having serious and progressive physical disorders. The risk of mortality among individuals with hypochondriasis is unknown. Objective: To investigate all-cause and cause-specific mortality among a large cohort of individuals wit

Importance: Prostate cancer, a leading cause of cancer death among men, urgently requires new prevention strategies, which may involve targeting men with an underlying genetic susceptibility. Objective: To explore differences in risk of early prostate cancer death among men with higher vs lower genetic risk to inform prevention efforts. Design, Setting, and Participants: This cohort study used a c

Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized p

Introduction: Risk evaluation for preeclampsia in early pregnancy allows identification of women at high risk. Prediction models for preeclampsia often include circulating concentrations of placental growth factor (PlGF); however, the models are usually limited to a specific PlGF method of analysis. The aim of this study was to compare three different PlGF methods of analysis in a Swedish cohort t

Background: Children with long-gap esophageal atresia (LGEA) risk living with aerodigestive morbidity and mental health difficulties. No previous study has investigated their experiences of schooling, despite the importance of schools in children’s development, learning and social relationships. We aimed to describe experiences of schooling in children with LGEA in Sweden in comparison with childr

Objective. To analyse the worldwide occurrence of sicca/Sjögren's (SS) syndrome associated with the use of immune checkpoint inhibitors (ICI) in patients with cancer. Methods. The ImmunoCancer International Registry (ICIR) is a Big Data- Sharing multidisciplinary network composed by 40 specialists in Rheumatology, Internal Medicine, Immunology and Oncology from 18 countries focused on the clinical

Increasing CO₂ emission is considered as the main reason for global warming in the world. One of the reasons for producing CO₂ is using of fossil-based materials in the construction projects. This study intends to assess the using bio-based materials instead of fossil-based materials for the thermal insulation layer of the external walls and roofs. Another focus of this project is using green conc

Background: Blood-based biomarkers for Alzheimer's disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics. We examined the potential of plasma markers Abeta(1-42/1-40), glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) to identify cerebral amyloidosis and/or disease severity. Methods

Background and aims: Children with extremely low-birth weight (ELBW) have a high risk for cognitive, motor, and attention impairments and learning disabilities. Longitudinal follow-up studies to a later age are needed in order to increase understanding of the changes in neurodevelopmental trajectories in targeting timely intervention. The aims of this study were to investigate cognitive and motor

What is already known about this subject Sagittal diameter (SAD), i.e. the mid height of the abdomen when lying down, has been reported to correlate to visceral fat, insulin resistance and cardiovascular risk factors in adults. SAD seems to be the best anthropometric predictor of cardiovascular risk, and also of more importance than waist circumference (WC) in adults. There has been no validation

It was estimated that about 0.5% of the world’s population is in need of assistive devices; in 2013, the number of people who required such aid was estimated at 25 million in Africa and Asia. The majority of these people could have increased their participation within society by receiving an assistive device to facilitate mobilisation, recognised as a step in accessing basic human rights such as f

Artskyddsförordningen kan föranleda en inskränkning av en skogsägares rådighet över sin skogsbruksfastighet. Rådighetsinskränkningen utgör ett ingrepp i en skogsägares äganderätt, vilket kan berättiga intrångsersättning. För att intrångsersättning ska erläggas krävs dels ett stadgande som berättigar intrångsersättning, dels att pågående markanvändning inom berör del av fastigheten avsevärt försvårForest owners' right of disposition over their forestry property units might be limited by restriction under the Species Protection Ordinance. The restriction of use constitutes a potential violation of the right to property. A forest owner may be entitled to compensation if there is a correlated regulation that justifies compensation and if the restriction of use causes a significant difficul